2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-E70121
    Succinyl-CoA synthetase
    Succinyl-CoA synthetase catalyzes the only substrate-level phosphoryl-ation step in the tricarboxylic acid cycle. Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism.
    Succinyl-CoA synthetase
  • HY-76082S1
    L-Pyroglutamic acid-13C5
    L-Pyroglutamic acid-13C5 is the 13C labeled L-Pyroglutamic acid (HY-76082). L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid can be used as a biomarker for systemic lupus erythematosus (SLE).
    L-Pyroglutamic acid-<sup>13</sup>C<sub>5</sub>
  • HY-B0141AS1
    Alpha-Estradiol-d2
    		≥99.0%
    Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
    Alpha-Estradiol-d<sub>2</sub>
  • HY-111054
    N-methyl-N-dithiocarboxyglucamine
    N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound 109Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication.
    N-methyl-N-dithiocarboxyglucamine
  • HY-Y0262S
    Oxalic Acid-d2
    Oxalic Acid-d2 is the deuterium labeled Oxalic Acid. Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic Acid-d<sub>2</sub>
  • HY-90006S2
    5-Fluorouracil-15N2
    		≥99.0%
    5-Fluorouracil-15N2 is the 15N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil-<sup>15</sup>N<sub>2</sub>
  • HY-14595R
    Biochanin A (Standard)
    Biochanin A (Standard) is the analytical standard of Biochanin A. This product is intended for research and analytical applications. Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor, which inhibits FAAH with IC50s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively.
    Biochanin A (Standard)
  • HY-128421R
    Tridecanedioic acid (Standard)
    Tridecanedioic acid (Standard) is the analytical standard of Tridecanedioic acid. This product is intended for research and analytical applications. Tridecanedioic acid is an endogenous metabolite.
    Tridecanedioic acid (Standard)
  • HY-N8515
    UDP-3-O-acyl-GlcNAc
    UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway.
    UDP-3-O-acyl-GlcNAc
  • HY-113456S
    Leukotriene D4-d5
    		98.4%
    Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
    Leukotriene D4-d<sub>5</sub>
  • HY-W923642
    Sphingomyelin (d18:1/12:0)
    		≥99.0%
    Sphingomyelin (d18:1/12:0) is a polar lipid with the activity of regulating cell signaling. Sphingomyelin (d18:1/12:0) plays an important role in cell membranes, affecting membrane fluidity and stability. Sphingomyelin (d18:1/12:0) is also involved in lipid metabolism and has the potential to promote neuronal cell growth. Sphingomyelin (d18:1/12:0) plays a key role in the function and development of the nervous system.
    Sphingomyelin (d18:1/12:0)
  • HY-121309
    Doxorubicinone
    		98.29%
    Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
    Doxorubicinone
  • HY-W016784R
    Indole-3-acetamide (Standard)
    Indole-3-acetamide (Standard) is the analytical standard of Indole-3-acetamide. This product is intended for research and analytical applications. Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid (HY-18569). Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class[1].
    Indole-3-acetamide (Standard)
  • HY-137555
    11-dehydro-2,3-dinor Thromboxane B2
    		≥99.0%
    11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030). It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation. Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.
    11-dehydro-2,3-dinor Thromboxane B2
  • HY-W023323
    (S)-β-Aminoisobutyric acid hydrochloride
    		99.68%
    (S)-β-Aminoisobutyric acid hydrochloride is a non-protein amino acid originating from the catabolism of thymine and valine.
    (S)-β-Aminoisobutyric acid hydrochloride
  • HY-N7092S2
    D-Fructose-13C-1
    		≥98.0%
    D-Fructose-13C-1 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
    D-Fructose-<sup>13</sup>C-1
  • HY-W015114R
    L-2-Hydroxyglutaric acid disodium (Standard)
    L-2-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of L-2-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
    L-2-Hydroxyglutaric acid disodium (Standard)
  • HY-N9516A
    Taurodehydrocholic acid sodium
    Taurodehydrocholic acid sodium is a biliary cholesterol secretion activator. Taurodehydrocholic acid sodium significantly increases the expression of Abcg5 and decreases the expression of abc8. Taurodehydrocholic acid sodium can be used in the study of cholesterol metabolism.
    Taurodehydrocholic acid sodium
  • HY-W011393
    L-Anserine nitrate
    		99.65%
    L-Anserine nitrate is an endogenous metabolite.
    L-Anserine nitrate
  • HY-76847R
    Chenodeoxycholic Acid (Standard)
    Chenodeoxycholic Acid (Standard) is the analytical standard of Chenodeoxycholic Acid. This product is intended for research and analytical applications. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
    Chenodeoxycholic Acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity