2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W001953
    2-Naphthalenemethanol
    		99.47%
    2-Naphthalenemethanol is the metabolite of environmental pollutant 2-methylnaphthalene. 2-Naphthalenemethanol covalently binds to alveolar protein and induces pulmonary toxicity.
    2-Naphthalenemethanol
  • HY-W067425
    2-(4-Hydroxyphenyl)propionic acid
    		98.66%
    2-(4-Hydroxyphenyl)propionic acid (Compound 1) is an aromatic carboxylic acid, which can be converted into its R and S glucosyl esters and glucosides by root culture of P. ginseng (Pg-1).
    2-(4-Hydroxyphenyl)propionic acid
  • HY-113405S1
    21-Deoxycortisol-d8
    		98.79%
    21-Deoxycortisol-d8 is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia.
    21-Deoxycortisol-d<sub>8</sub>
  • HY-113553
    4-Aminophenylphosphorylcholine
    		99.62%
    4-Aminophenylphosphorylcholine ((p-Aminophenyl)phosphocholine) is a probe that can be conjugated to agarose gels to generate adsorbents for affinity precipitation experiments.
    4-Aminophenylphosphorylcholine
  • HY-N0682R
    Pyridoxine hydrochloride (Standard)
    Pyridoxine (hydrochloride) (Standard) is the analytical standard of Pyridoxine (hydrochloride). This product is intended for research and analytical applications. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
    Pyridoxine hydrochloride (Standard)
  • HY-N0349S1
    Methyl Paraben-13C6
    		99.90%
    Methyl Paraben-13C6 (Methyl 4-hydroxybenzoate-13C6) is a 13C labeled Methyl Paraben (HY-N0349). Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity.
    Methyl Paraben-<sup>13</sup>C<sub>6</sub>
  • HY-113437AS
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate-d62 sodium
    		≥99.0%
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate-d62 (sodium) is deuterium labeled 1,2-Dipalmitoyl-sn-glycerol 3-phosphate. 1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite.
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate-d<sub>62</sub> sodium
  • HY-B1529
    Ammonium citrate dibasic, 99%
    		≥99.0%
    Ammonium citrate dibasic, 99% (Ammonium hydrogencitrate, 99%) can be used as the carbon source to prepare carbon quantum dots (CDs). Ammonium citrate dibasic, 99% is a buffering agent.
    Ammonium citrate dibasic, 99%
  • HY-136855
    MitoPBN
    MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50=~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.
    MitoPBN
  • HY-W016562R
    Hippuric acid (Standard)
    Hippuric acid (Standard) is the analytical standard of Hippuric acid. This product is intended for research and analytical applications. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research. .
    Hippuric acid (Standard)
  • HY-113118
    AAMU
    		99.34%
    AAMU (5-Acetylamino-6-amino-3-methyluracil) is the main metabolite of caffeine in the human body.
    AAMU
  • HY-126181
    5-Formylcytosine
    5-Formylcytosine is a modified base, which is oxidized from 5-methylcytosine. 5-Formylcytosine is a intermediate of in the active DNA demethylation.
    5-Formylcytosine
  • HY-15129R
    O-Phospho-L-serine (Standard)
    O-Phospho-L-serine (Standard) (L-Serine O-phosphate (Standard)) is the analytical standard of O-Phospho-L-serine (HY-15129). This product is intended for research and analytical applications. O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8). O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
    O-Phospho-L-serine (Standard)
  • HY-Y0511R
    N,N-Dimethylglycine (Standard)
    N,N-Dimethylglycine (Dimethylglycine) (Standard) is the analytical standard of N,N-Dimethylglycine (HY-Y0511). This product is intended for research and analytical applications. N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects.
    N,N-Dimethylglycine (Standard)
  • HY-I0626R
    Cytosine (Standard)
    Cytosine (Standard) is the analytical standard of Cytosine. This product is intended for research and analytical applications. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.
    Cytosine (Standard)
  • HY-W587796
    6-Phosphoglucono-δ-lactone
    6-Phosphoglucono-δ-lactone (6-PGδL) is a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD). 6-Phosphoglucono-δ-lactone is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research.
    6-Phosphoglucono-δ-lactone
  • HY-W010378R
    D-Asparagine (Standard)
    D-Asparagine (Standard) (H-D-Asn-OH (Standard)) is the analytical standard of D-Asparagine (HY-W010378). This product is intended for research and analytical applications. D-Asparagine (H-D-Asn-OH) is a competitive inhibitor of L-Asparagine hydrolysis with a Ki value of 0.24 mM. D-Asparagine is a source of nitrogen for yeast strains. D-Asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme.
    D-Asparagine (Standard)
  • HY-W744160
    Stigmasterol-d6
    Stigmasterol-d6 is deuterium-labeled Stigmasterol (HY-N0131).
    Stigmasterol-d<sub>6</sub>
  • HY-111952
    SR-4995
    		98.00%
    SR-4995 (CID 16016685) is a highly effective and selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), facilitating the activation of adipose triglyceride lipase (ATGL) by displacing ABHD5 from its inhibitory regulators, perilipin-1 (PLIN1) and PLIN5. It directly interacts with ABHD5, inhibiting its association with PLIN1, and promotes lipolysis in adipocytes and muscle tissues while circumventing PKA-dependent signaling pathways.
    SR-4995
  • HY-N2026S1
    Propylparaben-d4
    		99.00%
    Propylparaben-d4 is the deuterium labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats.
    Propylparaben-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity