2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113038AS1
    α-Hydroxyglutaric acid-d4 disodium
    α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
    α-Hydroxyglutaric acid-d<sub>4</sub> disodium
  • HY-B0617S1
    S-Adenosyl-L-methionine-13C
    S-Adenosyl-L-methionine-13C (S-Adenosyl methionine-13C) is the 13C labeled S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research.
    S-Adenosyl-L-methionine-<sup>13</sup>C
  • HY-B0166GL
    L-Ascorbic acid (GMP Like)
    		99.88%
    L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
    L-Ascorbic acid (GMP Like)
  • HY-B0199S
    Mycophenolate Mofetil-d4
    		99.80%
    Mycophenolate Mofetil-d4 is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation.
    Mycophenolate Mofetil-d<sub>4</sub>
  • HY-124265S
    4β-Hydroxycholesterol-d7
    		99.94%
    4β-Hydroxycholesterol-d7 is the deuterium labeled 4β-Hydroxy Cholesterol.
    4β-Hydroxycholesterol-d<sub>7</sub>
  • HY-17476
    Carbasalate calcium
    		98.0%
    Carbasalate calcium is an anti-inflammatory, antipyretic, and analgesic agent.
    Carbasalate calcium
  • HY-40136S
    cis-4-Hydroxy-L-proline-d3
    		≥99.0%
    cis-4-Hydroxy-L-proline-d3 is the deuterium labeled cis-4-Hydroxy-L-proline (HY-40136). cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension.
    cis-4-Hydroxy-L-proline-d<sub>3</sub>
  • HY-126912A
    Lauroyl coenzyme A lithium
    		99%
    Lauroyl coenzyme A lithium salt is an intermediary in fatty acid synthesis or metabolism, formed by combining long-chain fatty acids (or lauric acid) with coenzyme A. Lauroyl coenzyme A lithium salt is involved in lipid biosynthesis and fatty acid transport, in which coenzyme A acts as a transport molecule to help move and target specific compounds.
    Lauroyl coenzyme A lithium
  • HY-W105506
    Dimethylpropiothetin hydrochloride
    		98.0%
    Dimethylpropiothetin hydrochloride (s,s-Dimethyl-β-propionic acid thetine) is the hydrochloride form of dimethylpropiothetin. Dimethylpropiothetin can be isolated in marine algae, and is a precursor to dimethylsulfide (DMS). Dimethylpropiothetin is involved in osmoregulation in Hymenomonas carterae.
    Dimethylpropiothetin hydrochloride
  • HY-150012S1
    N-Lactoyl-Phenylalanine-13C6
    		98.47%
    N-Lactoyl-Phenylalanine-13C6 (Lac-Phe-13C6) is 13C labeled N-Lactoyl-Phenylalanine. N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-Phenylalanine can reduce obesity and improve glucose tolerance.
    N-Lactoyl-Phenylalanine-<sup>13</sup>C<sub>6</sub>
  • HY-B2246S
    L-Carnitine-d9 chloride
    		≥99.0%
    L-Carnitine-d9 (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism.
    L-Carnitine-d<sub>9</sub> chloride
  • HY-108496S
    Sphingosine-1-phosphate-d7
    		99.00%
    Sphingosine-1-phosphate-d7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12.?Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids.
    Sphingosine-1-phosphate-d<sub>7</sub>
  • HY-121883S4
    Lignoceric acid-d4-2
    		98.0%
    Lignoceric acid-d4-2 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research.
    Lignoceric acid-d<sub>4</sub>-2
  • HY-128553
    Antineoplaston A10
    		99.84%
    Antineoplaston A10 is an antineoplaston that inhibits the growth of human hepatoma cells by inducing apoptosis. Antineoplaston A10 can be used in the study of liver cancer and breast cancer.
    Antineoplaston A10
  • HY-B1659S6
    Glycerol-d5
    		99.0%
    Glycerol-d5 is the deuterium labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
    Glycerol-d<sub>5</sub>
  • HY-W923642
    Sphingomyelin (d18:1/12:0)
    		99.0%
    Sphingomyelin (d18:1/12:0) is a polar lipid with the activity of regulating cell signaling. Sphingomyelin (d18:1/12:0) plays an important role in cell membranes, affecting membrane fluidity and stability. Sphingomyelin (d18:1/12:0) is also involved in lipid metabolism and has the potential to promote neuronal cell growth. Sphingomyelin (d18:1/12:0) plays a key role in the function and development of the nervous system.
    Sphingomyelin (d18:1/12:0)
  • HY-P2802A
    α-Glucosidase, bacillus stearothermophilus
    α-Glucosidase, bacillus stearothermophilus is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, bacillus stearothermophilus retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate.
    α-Glucosidase, bacillus stearothermophilus
  • HY-130466S
    Stearoyl-L-carnitine-d3 chloride
    		99.80%
    Stearoyl-L-carnitine-d3 (chloride) is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM.
    Stearoyl-L-carnitine-d<sub>3</sub> chloride
  • HY-113283R
    Homogentisic acid (Standard)
    Homogentisic acid (Standard) is the analytical standard of Homogentisic acid. This product is intended for research and analytical applications. Homogentisic acid is a specific metabolite that accumulates in the urine and serum. Homogentisic acid can be used for diagnosis of alkaptonuria. Homogentisic acid is a phenolic acid.
    Homogentisic acid (Standard)
  • HY-W012530R
    Phenylpyruvic acid (Standard)
    Phenylpyruvic acid (Standard) is the analytical standard of Phenylpyruvic acid. This product is intended for research and analytical applications. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity.
    Phenylpyruvic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity