2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0304S
    L-DOPA-d6
    		≥99.0%
    L-DOPA-d6 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
    L-DOPA-d<sub>6</sub>
  • HY-113056AS
    N1-Acetylspermidine-d6 hydrochloride
    		99.88%
    N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA.
    N1-Acetylspermidine-d<sub>6</sub> hydrochloride
  • HY-B0389S
    D-Glucose-13C6,d7
    		98.0%
    D-Glucose-13C6,d7 is the deuterium and 13C labeled D-Glucose.
    D-Glucose-<sup>13</sup>C<sub>6</sub>,d<sub>7</sub>
  • HY-77839S
    Cortodoxone-d5
    		99.90%
    Cortodoxone-d5 is the deuterium labeled Cortodoxone.
    Cortodoxone-d<sub>5</sub>
  • HY-14608S1
    L-Glutamic acid-1-13C
    		99.85%
    L-Glutamic acid-1-13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
    L-Glutamic acid-1-<sup>13</sup>C
  • HY-N2037C
    (S)-Higenamine hydrobromide
    (S)-Higenamine ((S)-Norcoclaurine) hydrobromide, a S-enantiomer of Higenamine, is the entry compound in benzylisoquinoline alkaloid biosynthesis. (S)-Higenamine hydrobromide is produced by the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) by norcoclaurine synthase (NCS).
    (S)-Higenamine hydrobromide
  • HY-P3260
    5′-Nucleotidase, Microorganism
    5′-Nucleotidase, Microorganism (CD73) is an intrinsic membrane glycoprotein present as an ectoenzyme. 5′-Nucleotidase catalyzes hydrolysis of 5-nucleotides to their corresponding nucleosides.
    5′-Nucleotidase, Microorganism
  • HY-W001117
    3,5-Dimethoxyphenol
    		99.84%
    3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves.
    3,5-Dimethoxyphenol
  • HY-N0658A
    DL-Threonine
    		99.83%
    DL-Threonine, an essential amino acid, is a precursor of Glycine (HY-Y0966). DL-Threonine has the potential for the study of hypostatic leg ulceration.
    DL-Threonine
  • HY-W040256
    Acid phosphatase, wheat
    Acid phosphatase, wheat (ACP) is an enzyme that removes phosphate from other molecules during digestion. Acid phosphatase catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid.
    Acid phosphatase, wheat
  • HY-N0169R
    Hyodeoxycholic acid (Standard)
    Hyodeoxycholic acid (Standard) is the analytical standard of Hyodeoxycholic acid. This product is intended for research and analytical applications. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
    Hyodeoxycholic acid (Standard)
  • HY-N7433
    4,6-O-Ethylidene-α-D-glucose
    		98.0%
    4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport.
    4,6-O-Ethylidene-α-D-glucose
  • HY-W013061
    Propane-1,2,3-triyl tripalmitate
    		98.0%
    Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
    Propane-1,2,3-triyl tripalmitate
  • HY-P2895
    Clostripain
    Clostripain (Clostridiopeptidase B) is a proteolytic enzyme isolated from Clostridium histolyticum with esterase, amidase and protease activities and is a highly specific carboxypeptide targeting arginine key protease.
    Clostripain
  • HY-W008820R
    Glutaric acid (Standard)
    Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM.
    Glutaric acid (Standard)
  • HY-W001132R
    Indole (standard)
    Indole (Standard) is the analytical standard of Indole. This product is intended for research and analytical applications. Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule.
    Indole (standard)
  • HY-W007376S
    Indole-3-carboxaldehyde-13C3
    Indole-3-carboxaldehyde-13C (3-Formylindole-13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin.
    Indole-3-carboxaldehyde-<sup>13</sup>C<sub>3</sub>
  • HY-76847S3
    Chenodeoxycholic acid-d5
    		99.79%
    Chenodeoxycholic acid-d5 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
    Chenodeoxycholic acid-d<sub>5</sub>
  • HY-50723
    3-Methylxanthine
    		99.62%
    3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
    3-Methylxanthine
  • HY-N0610R
    trans-Cinnamic acid (Standard)
    trans-Cinnamic acid (Standard) is the analytical standard of trans-Cinnamic acid. This product is intended for research and analytical applications. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1.
    trans-Cinnamic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity