2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N9371
    Crocin IV
    		98.09%
    Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity.
    Crocin IV
  • HY-W008097
    3,3-Dimethylglutaric acid
    		98.92%
    3,3-Dimethylglutaric acid, a member of methyl-branched fatty acids, is a endogenous metabolite occasionally found in human urine. 3,3-Dimethylglutaric acid can be used as a ligand to synthesize metal complexes.
    3,3-Dimethylglutaric acid
  • HY-N1750
    3-(2,4-Dihydroxyphenyl)propanoic acid
    		99.46%
    3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively.
    3-(2,4-Dihydroxyphenyl)propanoic acid
  • HY-41417R
    Octanoic acid (Standard)
    Octanoic acid (Standard) is the analytical standard of Octanoic acid. This product is intended for research and analytical applications. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
    Octanoic acid (Standard)
  • HY-W012722R
    4-Methyl-2-oxopentanoic acid (Standard)
    4-Methyl-2-oxopentanoic acid (Standard) is the analytical standard of 4-Methyl-2-oxopentanoic acid. This product is intended for research and analytical applications. 4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid), an abnormal metabolite, is both a neurotoxin and a metabotoxin.
    4-Methyl-2-oxopentanoic acid (Standard)
  • HY-118840
    1,4-D-Gulonolactone
    		99.56%
    1,4-D-Gulonolactone is an endogenous metabolite.
    1,4-D-Gulonolactone
  • HY-N1427A
    Glycodeoxycholic acid monohydrate
    		98.0%
    Glycodeoxycholic acid monohydrate is a nuclear receptor ligand.
    Glycodeoxycholic acid monohydrate
  • HY-W105634
    Strombine
    Strombine is a imino acid produced by a dehydrogenase. Strombine is a compound present in the hemolymph that is capable of cryoprotection.
    Strombine
  • HY-N0469R
    L-Lysine (Standard)
    L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation. IC50 & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium.
    L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity. In Vivo:L-lysine (10?mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model. L-lysine (5 or 10?mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model.
    L-Lysine (Standard)
  • HY-113455
    9S-HODE
    		98.0%
    9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO.
    9S-HODE
  • HY-18733R
    Lipoic acid (Standard)
    Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
    Lipoic acid (Standard)
  • HY-N0684S3
    Vitamin K1-13C6
    		≥99.0%
    Vitamin K1-13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
    Vitamin K1-<sup>13</sup>C<sub>6</sub>
  • HY-N0322S4
    Cholesterol-13C3
    		98.80%
    Cholesterol-13C3 is the 13C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
    Cholesterol-<sup>13</sup>C<sub>3</sub>
  • HY-Y1177
    Diphenyl disulfide
    		99.96%
    Diphenyl disulfide is an endogenous metabolite.Diphenyl disulfide is a pharmaceutical intermediate. Diphenyl disulfide can be coupled with aryl iodide to synthesize asymmetric aryl sulfide.
    Diphenyl disulfide
  • HY-13211
    (E)-2-Decenoic acid
    		99.28%
    (E)-2-Decenoic acid is an interesting fatty acid isolated from royal jelly secretions of honey bees.
    (E)-2-Decenoic acid
  • HY-I0960S3
    Uracil-13C4,15N2
    		≥98.0%
    Uracil-13C4,15N2 is the 13C and 15N labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
    Uracil-<sup>13</sup>C<sub>4</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-P1563
    Osteogenic Growth Peptide, OGP
    		98.35%
    Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.
    Osteogenic Growth Peptide, OGP
  • HY-W011690S
    L-Homocystine-d8
    		99.90%
    L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
    L-Homocystine-d<sub>8</sub>
  • HY-101037R
    Sarcosine (Standard)
    Sarcosine (Standard) is the analytical standard of Sarcosine. This product is intended for research and analytical applications. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia.
    Sarcosine (Standard)
  • HY-E70007
    Catechol O-methyltransferase, porcine liver
    Catechol O-methyltransferase, porcine liver (COMT), the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain.
    Catechol O-methyltransferase, porcine liver
Cat. No. Product Name / Synonyms Application Reactivity