2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP
  5. ADAM8 Isoform
  6. ADAM8 Inhibitor

ADAM8 Inhibitor

ADAM8 Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-120852
    JG26
    		Inhibitor 98.01%
    JG26 is an ADAM inhibitor with IC50 values of 12 nM, 1.9 nM, and 150 nM for ADAM8, ADAM17, and ADAM10, respectively. JG26 inhibits MMP-12 with an IC50 value of 9.4 nM. JG26 inhibits AngII (HY-13948)-induced EGFR transactivation and ERK activation. JG26 increases the expression of ACE2, inhibits the cleavage of CD23, reduces the infection of SARS-CoV-2. JG26 inhibits colorectal cancer metastasis. JG26 can be used for research on Hodgkin lymphoma and vascular diseases.