2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MAGL

MAGL

Monoacylglycerol lipase

MAGL

Related Products

PDF 0.44 MB

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the hydrolysis of monoglycerides into glycerol and fatty acids. MAGL links the endocannabinoid and eicosanoid systems together by degradation of the abundant endocannabinoid 2-arachidaoylglycerol into arachidonic acid, the precursor of prostaglandins and other inflammatory mediators.

MAGL plays a critical role in lipid signalling: i) it is the major enzyme that controls the levels of 2-AG, an important lipid with various neuroprotective effects; ii) inactivation of MAGL induces an elevation in brain levels of 2-AG and a reduction of AA, a key precursor of pro-inflammatory prostaglandins, resulting in the reduction of neuroinflammation; iii) MAGL regulates the levels of free fatty acids (FFAs) in aggressive cancer cells, and this MAGL-promoted fatty acid network drives a number of pro-tumorigenic signalling pathways. MAGL is emerging as a promising drug target for various diseases.

MAGL Related Products (72):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163202
    MAGL-IN-13
    		Inhibitor
    MAGL-IN-13 (compound (3R, 4S) - 5v) is a selective, irreversible inhibitor for MAGL,with IC50 values of 0.026, 0.021 and 0.24 nM for mMAGL, hMAGL and rMAGL, respectively. MAGL-IN-13 can penetrant blood brain barrier. .
    MAGL-IN-13
  • HY-124576
    ABD-1970
    		Inhibitor
    ABD-1970 is a selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 15 nM and 29 nM for human and mouse MAGL, respectively. ABD-1970 shows selectivity for MGLL over other members of the serine hydrolase class. ABD-1970 has the potential for the study of neurological disorders.
    ABD-1970
  • HY-162305
    MAGL-IN-15
    		Inhibitor
    MAGL-IN-15 (Compound 6) is a MAGL inhibitor that can be used in the research of diseases and disorders related to the regulation of endocannabinoid system signaling activities.
    MAGL-IN-15
  • HY-103339
    VDM11
    		Inhibitor
    VDM11 is a potent and selective anandamide membrane transporter (AMT) inhibitor. VDM11 inhibits FAAH and MAGL and may act as an alternative FAAH substrate.
    VDM11
  • HY-12332R
    JW 642 (Standard)
    		Inhibitor
    JW 642 (Standard) is the analytical standard of JW 642. This product is intended for research and analytical applications.
    JW 642 (Standard)
  • HY-157042
    MAGL-IN-11
    		Inhibitor
    MAGL-IN-11 (compound 29) is a selective and reversible MAGL inhibitor. MAGL-IN-11 has the potential to study inflammation, cancer and antioxidants.
    MAGL-IN-11
  • HY-77491
    FAAH/MAGL-IN-5
    		Inhibitor 99.17%
    AM6701 is a potent FAAH/MAGL inhibitor (equipotent inhibitory IC50: 1.2 nM) with neuroprotective effects.
    FAAH/MAGL-IN-5
  • HY-157041
    MAGL-IN-10
    		Inhibitor
    MAGL-IN-10 is areversible monoacylglycerol lipase (MAGL) inhibitor with very good ADME properties and low in vivo toxicity.MAGL-IN-10 can be used for the research ofcancer, neurological disorders and inflammatory pathologies.
    MAGL-IN-10
  • HY-116143
    MAGL-IN-12
    		Inhibitor
    SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.
    MAGL-IN-12
  • HY-168145
    MAGL-IN-19
    		Inhibitor
    MAGL-IN-19 (compund 7o) is a highly potent and selective MAGL inhibitor.
    MAGL-IN-19
  • HY-157040
    MAGL-IN-9
    		Inhibitor
    MAGL-IN-9 (compound 16) is a selective and reversible MAGL inhibitor with IC50 2.7 nM.
    MAGL-IN-9
  • HY-169239
    MAGL-IN-20
    		Inhibitor
    MAGL-IN-20 (compound ±34) is a reversible monoacylglycerol lipase (MAGL) inhibitor. MAGL-IN-20 exhibits appreciable antiproliferative activities against several cancer cells, including H460, HT29, CT-26, Huh7 and HCCLM-3..
    MAGL-IN-20