2. Signaling Pathways
  3. PROTAC
  4. Ligands for E3 Ligase
  5. Cereblon Isoform

Cereblon

 

Cereblon Related Products (114):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W248665A
    Thalidomide-pyrrolidine hydrochloride 2616553-35-4 ≥98.0%
    Thalidomide-pyrrolidine hydrochloride (compound 18) is an E3 ligase ligand, and can be used for synthesis of PROTACs.
    Thalidomide-pyrrolidine hydrochloride
  • HY-150839
    E3 ligase Ligand PG 14149-34-9 99.94%
    E3 ligase Ligand PG is a E3 ligase ligand that can be used in the recruitment of CRBN protein. E3 ligase Ligand PG exhibits potent binding activity with CRBN (IC50 of 2.191 μM). E3 ligase Ligand PG can be connected to the BMS-202 (HY-19745) by a linker to form PROTAC, PROTAC PD-L1 degrader-1 (HY-163757).
    E3 ligase Ligand PG
  • HY-143715
    Cereblon inhibitor 1 2672489-14-2 99.19%
    Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.
    Cereblon inhibitor 1
  • HY-14658S
    Thalidomide-d4 1219177-18-0 98.00%
    Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
    Thalidomide-d<sub>4</sub>
  • HY-A0003S
    Lenalidomide-d5 1227162-34-6 99.32%
    Lenalidomide-d5 is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.
    Lenalidomide-d<sub>5</sub>
  • HY-153661
    Cereblon inhibitor 2 2639380-62-2 98.86%
    Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer.
    Cereblon inhibitor 2
  • HY-139548
    Thalidomide-5-methyl 40313-92-6 99.87%
    Thalidomide-5-methyl is the Thalidomide (HY-14658)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Thalidomide-5-methyl can be used to synthesize PROTAC.
    Thalidomide-5-methyl
  • HY-139540
    Pomalidomide-6-OH 1547162-44-6 98.09%
    Pomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-6-OH
  • HY-160244
    Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride 2758431-93-3 98.08%
    Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride
  • HY-14658B
    (R)-Thalidomide 2614-06-4 99.80%
    (R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has psychomotor stabilizing properties.
    (R)-Thalidomide
  • HY-A0003A
    Lenalidomide hydrochloride 1243329-97-6
    Lenalidomide hydrochloride (CC-5013 hydrochloride), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hydrochloride is an orally active immunomodulator. Lenalidomide hydrochloride (CC-5013 hydrochloride) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hydrochloride (CC-5013 hydrochloride) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.
    Lenalidomide hydrochloride
  • HY-10984S2
    Pomalidomide-d4 1416575-78-4
    Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors<
    Pomalidomide-d<sub>4</sub>
  • HY-161467
    Aster-A Ligand-3 2375541-28-7
    Aster-A Ligand-3 is a target protein ligand and can be used to synthesize PROTAC Aster-A degrader (HY-D2336).
    Aster-A Ligand-3
  • HY-161639
    E3 ligase Ligand 26 2911613-35-7
    E3 ligase Ligand 26 (part of Compd 10) is a ligand for E3 ligase, used for the synthesis of PROTAC SOS1 degrader (HY-161636).
    E3 ligase Ligand 26
  • HY-W1003189
    E3 ligase Ligand 42 2753651-18-0
    E3 ligase Ligand 42 is an E3 ubiquitin ligase ligand. E3 ligase Ligand 42 can be connected to the target protein ligand through a linker and can be used to synthesize PROTAC AR Degrader-6 (HY-156751). PROTAC can induce ubiquitination degradation of cancer-promoting proteins.
    E3 ligase Ligand 42
  • HY-144983
    E3 ligase Ligand 22 2377849-57-3
    E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway.
    E3 ligase Ligand 22
  • HY-139541
    Pomalidomide-5-O-CH3 1547163-02-9
    Pomalidomide-5-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-5-O-CH3
  • HY-158152
    PROTAC CRBN ligand-2
    PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC50 of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV.
    PROTAC CRBN ligand-2
  • HY-W584986
    Thalidomide-(2)piperidine 2616553-33-2
    Thalidomide-(2)piperidine (compound 9) is a potent E3 ligase ligand. Thalidomide-(2)piperidine can be used for synthesis of PROTACs.
    Thalidomide-(2)piperidine
  • HY-170449
    E3 ligase Ligand 48
    E3 ligase Ligand 48 is a CRBN ligand for PROTAC AR Degrader-9 (HY-170448). PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM.
    E3 ligase Ligand 48