2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W005598
    2-Hydroxyquinoline
    		Inhibitor 99.89%
    2-Hydroxyquinoline is an inhibitor of α-glucosidase and α-amylase with IC50 values of 64.4 µg/mL and 130.5 µg/mL, respectively. 2-Hydroxyquinoline can be used in the study of diabetes.
    2-Hydroxyquinoline
  • HY-131114
    Valiolamine
    		Inhibitor ≥98.0%
    Valiolamine is an aminocyclitol. Valiolamine has potent alpha-glucosidase inhibitory activity against porcine intestinal sucrase, maltase and isomaltase.
    Valiolamine
  • HY-N7659A
    Glucobrassicin potassium
    Glucobrassicin potassium is a glucosinolate (GSL) isolated from wild carrot (Raphanus raphanistrum L.). Glucobrassicin can be used in biological fumigation or allelopathy research for weed management.
    Glucobrassicin potassium
  • HY-16134
    Celgosivir
    		Inhibitor
    Celgosivir (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay.
    Celgosivir
  • HY-150560
    α-Glucosidase-IN-11
    		Inhibitor
    α-Glucosidase-IN-11 is a highly permeable competitive α-glucosidase inhibitor with the IC50 value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels.
    α-Glucosidase-IN-11
  • HY-P2950A
    α1-6 Mannosidase, Xanthomonas phaseoli
    α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that removes unbranched α1-6 linked mannose residues from oligosaccharides.
    α1-6 Mannosidase, Xanthomonas phaseoli
  • HY-U00090
    N-Methylmoranoline
    		Inhibitor ≥99.0%
    N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
    N-Methylmoranoline
  • HY-117861
    ML198
    		Modulator ≥98.0%
    ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease. ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    ML198
  • HY-B1039AS
    Ambroxol-d5 hydrochloride
    		Activator 99.46%
    Ambroxol-d5 (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
    Ambroxol-d<sub>5</sub> hydrochloride
  • HY-160426
    Gcase activator 3
    		Activator 99.67%
    Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies.
    Gcase activator 3
  • HY-N3542
    Carpachromene
    		Inhibitor 98.84%
    Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway.
    Carpachromene
  • HY-E70132
    Endo-β-N-acetylglucosaminidase D
    Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate.
    Endo-β-N-acetylglucosaminidase D
  • HY-W112651
    2,4,6-Triphenylaniline
    		Inhibitor
    2,4,6-Triphenylaniline has anti-diabetic activity and can be encapsulated in nano-emulsions (NE) to enhance stability and permeability. The NE loaded with 2,4,6-Triphenylaniline inhibits α-glucosidase and α-amylase.
    2,4,6-Triphenylaniline
  • HY-132177C
    α1-3,4 Fucosidase, Bifidobacterium bifidum
    α1-3,4 Fucosidase, Bifidobacterium bifidum is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing α1-3 and α1-4 linked fucose residues from oligosaccharides and glycoproteins.
    α1-3,4 Fucosidase, Bifidobacterium bifidum
  • HY-N8517
    Malabaricone B
    		Inhibitor 99.58%
    Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.
    Malabaricone B
  • HY-N7763
    Casuarictin
    		Inhibitor 98.62%
    Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research.
    Casuarictin
  • HY-N2383
    Validamine
    		Inhibitor
    Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme.
    Validamine
  • HY-N10413
    Diphlorethohydroxycarmalol
    		Inhibitor 98.46%
    Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities.
    Diphlorethohydroxycarmalol
  • HY-132177B
    α1-2,4,6 Fucosidase O, Omnitrophica bacterium
    α1-2,4,6 Fucosidase O (EC 3.2.1.51) is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal α1-2, α1-4 and α1-6 linked fucose residues from oligosaccharides, with α1-6 fucose residues more efficiently.
    α1-2,4,6 Fucosidase O, Omnitrophica bacterium
  • HY-16194
    Emiglitate
    		Inhibitor ≥98.0%
    Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase.
    Emiglitate
Cat. No. Product Name / Synonyms Application Reactivity