2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100666R
    Fosfluconazole (Standard)
    		Inhibitor
    Fosfluconazole (Standard) is the analytical standard of Fosfluconazole. This product is intended for research and analytical applications. Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.
    Fosfluconazole (Standard)
  • HY-138100
    Hyalodendrin
    		Inhibitor
    Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice.
    Hyalodendrin
  • HY-B1884R
    Procymidone (Standard)
    		Inhibitor
    Procymidone (Standard) is the analytical standard of Procymidone. This product is intended for research and analytical applications. Procymidone, a pesticide, is an immunogen hapten that can be combined with cOVA (carrier protein) to produce polyclonal antibodies. Procymidone has antifungal activity.
    Procymidone (Standard)
  • HY-111201
    Iodiconazole
    		Inhibitor
    Iodiconazole (ADKZ) is a new antifungal compound.
    Iodiconazole
  • HY-12538R
    Graveoline (Standard)
    		Inhibitor
    Graveoline (Standard) is the analytical standard of Graveoline. This product is intended for research and analytical applications. Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity.
    Graveoline (Standard)
  • HY-N13156
    Amycolatopsin B
    		Inhibitor
    Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494.
    Amycolatopsin B
  • HY-N14838
    Neoenactin A
    		Inhibitor
    Neoenactin A has strong anti-yeastlike and filamentous fungal effects.
    Neoenactin A
  • HY-106541R
    Neticonazole (Standard)
    		Inhibitor
    Neticonazole (Standard) is the analytical standard of Neticonazole. This product is intended for research and analytical applications. Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects.
    Neticonazole (Standard)
  • HY-N15600
    Merulidial
    		Inhibitor
    Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .
    Merulidial
  • HY-125539
    Roridin E
    		Inhibitor
    Roridin E is an antibiotic that has cell-inhibiting and fungicidal activities similar to verrucarin.
    Roridin E
  • HY-136355R
    Picoxystrobin (Standard)
    		Inhibitor
    Picoxystrobin (Standard) is the analytical standard of Picoxystrobin (HY-136355). This product is intended for research and analytical applications. Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
    Picoxystrobin (Standard)
  • HY-12638R
    Dichlorophen (Standard)
    		Inhibitor
    Dichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections.
    Dichlorophen (Standard)
  • HY-N14471
    Fusacandin A
    		Inhibitor
    Fusacandin A inhibits (1,3)-β-glucan synthetase and has antifungal properties.
    Fusacandin A
  • HY-N14429
    Fredericamycin A
    		Inhibitor
    Fredericamycin A has anti-Gram-positive bacterial and fungal activity, and shows strong anti-tumor effect in vivo and in vitro.
    Fredericamycin A
  • HY-N14679
    Pinselin
    		Inhibitor
    Pinselin is a nitrogen-containing heterocyclic antibiotic. Pinselin has anti-yeast activity.
    Pinselin
  • HY-N14114
    Curvularol
    		Inhibitor
    Curvularol has weak anti-fungal activity and no anti-bacterial effect. Curvularol of 150 ng/mL inhibits the cell cycle progression of NRK in normal rats at G1 stage. Curvularol of 100 ng/mL can restore the morphology of SRC TS-deformed NRK cells. Curvularol inhibits protein synthesis.
    Curvularol
  • HY-N12056
    Cyclo(L-leucyl-L-valyl)
    Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA..
    Cyclo(L-leucyl-L-valyl)
  • HY-W097994
    DHMB
    		Inhibitor
    DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is a small organic molecule with anti-fungal and anti-inflammatory activity. DHMB has protective effect on intestinal epithelial cells.
    DHMB
  • HY-136425R
    Fosetyl-aluminum (Standard)
    		Inhibitor
    Fosetyl-aluminum (Standard) is the analytical standard of Fosetyl-aluminum. This product is intended for research and analytical applications. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops.
    Fosetyl-aluminum (Standard)
  • HY-N3056R
    Pinosylvin monomethyl ether (Standard)
    Pinosylvin monomethyl ether (Standard) is the analytical standard of Pinosylvin monomethyl ether. This product is intended for research and analytical applications. Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity.
    Pinosylvin monomethyl ether (Standard)
Cat. No. Product Name / Synonyms Application Reactivity