2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10228
    S-Thanatin
    		Inhibitor
    S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na+/K+) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner.
    S-Thanatin
  • HY-126780
    Nikkomycin N
    		Inhibitor
    Nikkomycin N is a nucleoside antibiotic, which is initially produced by Streptomyces tendae. Nikkomycin N exhibits fungicidal and insecticidal properties through inhibition of chitin synthesis.
    Nikkomycin N
  • HY-155702
    Antifungal agent 66
    		Inhibitor
    Antifungal agent 66 (compound 10) has antifungal activity. Antifungal agent 66 has a broad-spectrum antifungal activity against seven phytopathogenic fungal mycelia. Antifungal agent 66 has pronounced inhibitory activity against the spore of B. cinerea with an IC50 value of 47.7 μg/mL.
    Antifungal agent 66
  • HY-N10014
    Bulnesol
    		Inhibitor
    Bulnesol is a sesquiterpenoid that can be isolated from Salvia dorystaechas. Bulnesol inhibits the activity of Fusarium moniliforme with an EC50 value of 0.6 mg/mL. Bulnesol can be used for the research of fungal infection.
    Bulnesol
  • HY-125511
    Chaetoviridin A
    		Inhibitor
    Chaetoviridin A exhibits antifungal activity against several plants pathogen, inhibits growth of Verticillium dahliae through cell necrosis and mycelial deformation, and thus improves sensitivity of V. dahliae to stress, increases the emergence rate and plant height of cotton.
    Chaetoviridin A
  • HY-Y0569BR
    D-Gluconic acid calcium hydrate (Standard)
    		Inhibitor
    D-Gluconic acid (calcium hydrate) (Standard) is the analytical standard of D-Gluconic acid (calcium hydrate). This product is intended for research and analytical applications. D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.
    D-Gluconic acid calcium hydrate (Standard)
  • HY-163979
    Antifungal agent 109
    		Inhibitor
    Antifungal agent 109 (compound F) is a spirothiazolidinone compound with antifungal activity, with an inhibition zone of 10-17 mm.
    Antifungal agent 109
  • HY-B1444R
    Isoconazole nitrate (Standard)
    		Inhibitor
    Isoconazole (nitrate) (Standard) is the analytical standard of Isoconazole (nitrate). This product is intended for research and analytical applications. Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential.
    Isoconazole nitrate (Standard)
  • HY-N0957
    (±)-Pinoresinol
    		Inhibitor
    (±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity.
    (±)-Pinoresinol
  • HY-130765
    Ferbam
    		Inhibitor
    Ferbam (Iron(III) dimethyldithiocarbamate) is a potent fungicide.
    Ferbam
  • HY-N15619
    Pterygospermin
    		Inhibitor
    Pterygospermin is an antibiotic compound found in Moringa. Pterygospermin has antibacterial has fungicidal activity.
    Pterygospermin
  • HY-149492
    Phosphatase-IN-1
    		Inhibitor
    Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a phosphatidate phosphatase (Pah) inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads.
    Phosphatase-IN-1
  • HY-147238
    Antifungal agent 35
    		Inhibitor
    Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans.
    Antifungal agent 35
  • HY-W505771
    Seselin
    		Inhibitor 99.55%
    Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active.
    Seselin
  • HY-153623
    Antifungal agent 58
    		Inhibitor
    Antifungal agent 58 (compound A21) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 58 is more effective than Miconazole (HY-B0454). Antifungal agent 58 inhibits Candida albicans strains with MIC values of 0.06-8 μg/mL.
    Antifungal agent 58
  • HY-P2098
    Alamethicin F 50
    		Inhibitor
    Alamethicin F 50 is an antibiotic. Alamethicin F 50 is composed of membrane-active peptide, containing 75% Alamethicin F 50/5 and 10% Alamethicin F 50/7. Alamethicin F 50 is exhibits antifungal and antibacterial activity by disrupting the integrity of microbial cell membranes, resulting in leakage of cell contents and death of the microorganisms. Alamethicin F 50 is able to reduce the surface tension of water, which can be used as a surfactant or detergent.
    Alamethicin F 50
  • HY-W750064
    Acetophenone-13C8
    Acetophenone-13C8 (1-Phenylethan-1-One-13C8) is the 13C-labeled Acetophenone (HY-Y0989). Acetophenone (1-Phenylethan-1-One) is an organic compound with simple structure. Acetophenone can be bioreduced to phenylethanol (PEA).
    Acetophenone-<sup>13</sup>C<sub>8</sub>
  • HY-W016867R
    4-Chlorosalicylic acid (Standard)
    		Inhibitor
    4-Chlorosalicylic acid (Standard) is the analytical standard of 4-Chlorosalicylic acid. This product is intended for research and analytical applications. 4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.
    4-Chlorosalicylic acid (Standard)
  • HY-N6783
    Oligomycin C
    		Inhibitor
    Oligomycin C is a macrolide antibiotic produced by Streptomyces strains. Oligomycin C exhibits a strong activity against Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici but no activity toward bacteria.
    Oligomycin C
  • HY-W040129R
    Chromomycin A3 (Standard)
    		Inhibitor
    Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe.
    Chromomycin A3 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity