2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0293A
    Butoconazole
    		Inhibitor
    Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis.
    Butoconazole
  • HY-W109523
    2-Butylbenzo[d]isothiazol-3(2H)-one
    		Inhibitor
    2-Butylbenzo[d]isothiazol-3(2H)-one is a bioactive compound with potent antibacterial and antifungal activity. 2-Butylbenzo[d]isothiazol-3(2H)-one is often used as a pesticide ingredient in agriculture to protect crops from diseases. 2-Butylbenzo[d]isothiazol-3(2H)-one is also used in coatings to prevent the growth of mold and algae. 2-Butylbenzo[d]isothiazol-3(2H)-one is also used as a preservative in personal care products to extend the shelf life of the product.
    2-Butylbenzo[d]isothiazol-3(2H)-one
  • HY-119759
    Lipoxamycin
    		Inhibitor
    Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM.
    Lipoxamycin
  • HY-129315
    Deacylketoconazole
    		Inhibitor 99.60%
    Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte.
    Deacylketoconazole
  • HY-N7107
    Fenchyl alcohol
    		Inhibitor
    Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer.
    Fenchyl alcohol
  • HY-137989
    Voriconazole N-oxide
    		Inhibitor
    Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB).
    Voriconazole N-oxide
  • HY-N3187
    Nimbin
    		Inhibitor 99.59%
    Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections.
    Nimbin
  • HY-N12496
    Di-O-methylhonokiol
    		Inhibitor 99.59%
    Di-O-methylhonokiol is a natural phenolic compound that can be isolated from magnolia flowers. Di-O-methylhonokiol has significant antibacterial activity against Gram-positive bacteria, acid-fast bacilli, and yeast-like and filamentous fungi. Di-O-methylhonokiol can be used in the study of fungal infections.
    Di-O-methylhonokiol
  • HY-100751
    N-563
    		≥98.0%
    N-563 is a deoxyspergualin mimetic that stimulates immune responses and enhances resistance to Candida albicans in mice.
    N-563
  • HY-114275
    Justicidin B
    		Inhibitor ≥99.0%
    Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation.
    Justicidin B
  • HY-N10229
    Harzianum A
    		Inhibitor
    Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells.
    Harzianum A
  • HY-P0263
    Dermaseptin
    		Inhibitor 98.77%
    Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration.
    Dermaseptin
  • HY-N0673
    Pseudolaric Acid A
    		Inhibitor 99.90%
    Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities.
    Pseudolaric Acid A
  • HY-B0139S
    Flucytosine-13C,15N2
    		Inhibitor 98.06%
    Flucytosine-13C,15N2 (NSC 103805-13C,15N2; Ro 2-9915-13C,15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
    Flucytosine-<sup>13</sup>C,15</sup>N<sub>2</sub>
  • HY-W012349
    2′-Hydroxychalcone
    		Inhibitor
    2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp.
    2′-Hydroxychalcone
  • HY-B2012R
    Flusilazole (Standard)
    		Inhibitor
    Flusilazole (Standard) is the analytical standard of Flusilazole. This product is intended for research and analytical applications. Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture and horticulture.
    Flusilazole (Standard)
  • HY-B0853R
    Paclobutrazol (Standard)
    		Inhibitor
    Paclobutrazol (Standard) is the analytical standard of Paclobutrazol. This product is intended for research and analytical applications. Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins. Paclobutrazol also has antifungal activities. Paclobutrazol, transported acropetally in plants, can also suppress the synthesis of abscisic acid and induce chilling tolerance in plants. Paclobutrazol is typically used to support research on the role of gibberellins in plant biology.
    Paclobutrazol (Standard)
  • HY-P5594
    Dermaseptin-S1
    		Inhibitor
    Dermaseptin-S1 is an antimicrobial peptide derived from frog skin against filamentous fungi.
    Dermaseptin-S1
  • HY-W016806
    Sodium methylparaben, 99%
    		Inhibitor 98.00%
    Sodium methylparaben, 99% (Sodium methyl 4-hydroxybenzoate, 99%) is an antifungal agent.
    Sodium methylparaben, 99%
  • HY-B0843AR
    Metalaxyl-M (Standard)
    		Inhibitor
    Metalaxyl-M ((R)-Metalaxyl) (Standard) is the analytical standard of Metalaxyl-M (HY-B0843A). This product is intended for research and analytical applications. Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies.
    Metalaxyl-M (Standard)
Cat. No. Product Name / Synonyms Application Reactivity