2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N3574
    Chloramultilide B
    		Inhibitor
    Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candida albicans and C.parapsilosis with a MIC value of 0.068 μM.
    Chloramultilide B
  • HY-P5016A
    CRAMP-18 (mouse) acetate
    		Inhibitor 99.33%
    CRAMP-18 (mouse) acetate is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) acetate has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) acetate has the potential to study antifungal, antibacterial and antitumor.
    CRAMP-18 (mouse) acetate
  • HY-N0328R
    alpha-Mangostin (Standard)
    		Inhibitor
    alpha-Mangostin (Standard) is the analytical standard of alpha-Mangostin. This product is intended for research and analytical applications. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
    alpha-Mangostin (Standard)
  • HY-N2502
    Tetradehydropodophyllotoxin
    		Inhibitor 99.63%
    Tetradehydropodophyllotoxin possesses antifungal activity.
    Tetradehydropodophyllotoxin
  • HY-N4088
    Pseudolaric acid A-O-β-D-glucopyranoside
    		99.67%
    Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities.
    Pseudolaric acid A-O-β-D-glucopyranoside
  • HY-B1796
    Thymol iodide
    		Inhibitor
    Thymol iodide is a compound of Iodide and Thymol. Thymol iodide acts as a substitute for iodoform. Thymol iodide is an iodine derivative of Thymol (a phenol derived from thyme oil), which is mostly used as mild antiseptic and fungicide.
    Thymol iodide
  • HY-W001251
    3,5-Dimethoxybenzoic acid
    		Inhibitor 99.66%
    3,5-Dimethoxybenzoic acid, isolated from Melia azedarach L. leaves with antifungal activity, is an intermediate in organic synthesis.
    3,5-Dimethoxybenzoic acid
  • HY-153671
    4'-Methyl-β-naphthoflavone
    		99.88%
    4'-Methyl-β-naphthoflavone is a metabolite of Naphthoflavones (benzoflavones) in fungal. Naphthoflavones are activators or inhibitors of CYP-450.
    4'-Methyl-β-naphthoflavone
  • HY-N10311
    Neosartoricin B
    		Modulator
    Neosartoricin B is the secondary metabolite, which can be produced by Aspergillus nidulans. Neosartoricin B may regulate immunomodulatory effects with the host during infection and colonization by pathogenic fungi.
    Neosartoricin B
  • HY-P2460
    SMAP-29
    		Inhibitor 98.68%
    SMAP-29, a promising antiinfective agent, is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide. SMAP-29 acts by permeabilizing bacterial membranes and inducing remarkable changes in the surface morphology of susceptible microorganism.
    SMAP-29
  • HY-W019803
    Diclobutrazol
    		Inhibitor 99.20%
    Diclobutrazol, a systemic fungicide, is highly active against rusts, powdery mildews, and other fungal phytopathogens. Diclobutrazol can be used as a pesticide to control of various crop diseases.
    Diclobutrazol
  • HY-100379
    Valrocemide
    		Inhibitor 99.42%
    Valrocemide (TV1901) is a promising antiepileptic agent candidate that shows a broad spectrum of anticonvulsant activity.
    Valrocemide
  • HY-44688
    S.pombe lumazine synthase-IN-1
    		Inhibitor 98.02%
    S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively.
    S.pombe lumazine synthase-IN-1
  • HY-N8284
    Tomentosin
    		Inhibitor 98.95%
    Tomentosin is an orally active natural sesquiterpenoid lactone. Tomentosin exhibits multiple activities such as anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant and neuroprotective effects. Tomentosin can inhibit tumor cell proliferation, migration and invasion, and induce apoptosis. Tomentosin can be used in the research of tumors, inflammation and nervous system diseases.
    Tomentosin
  • HY-N3556
    Caulilexin C
    		Inhibitor 99.82%
    Caulilexin C is a phytoalexin from crucifers with antifungal activity.
    Caulilexin C
  • HY-W342499
    3-Hydroxy myristic acid methyl ester
    		Inhibitor ≥98.0%
    3-Hydroxy myristic acid methyl ester (Methyl 3-hydroxytetradecanoate) is the quorum-sensing signal molecule (quormone), which regulates the virulence of Ralstonia solanacearum.
    3-Hydroxy myristic acid methyl ester
  • HY-153409
    Antifungal agent 48
    		Inhibitor
    Antifungal agent 48 (Example 308) is an antifungal agent. Antifungal agent 48 is active against Cryptococcus neoformans with a MIC value of 11 μM.
    Antifungal agent 48
  • HY-148697
    Nigerose
    Nigerose is a disaccharide.
    Nigerose
  • HY-17583R
    Griseofulvin (Standard)
    		Inhibitor
    Griseofulvin (Standard) is the analytical standard of Griseofulvin. This product is intended for research and analytical applications.
    Griseofulvin (Standard)
  • HY-17514S2
    Itraconazole-d9
    Itraconazole-d9 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
    Itraconazole-d<sub>9</sub>
Cat. No. Product Name / Synonyms Application Reactivity