2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Y0055R
    Phenothiazine (Standard)
    		Inhibitor
    Phenothiazine (Standard) is the analytical standard of Phenothiazine. This product is intended for research and analytical applications. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.
    Phenothiazine (Standard)
  • HY-B1790R
    Terconazole (Standard)
    		Inhibitor
    Terconazole (Standard) is the analytical standard of Terconazole. This product is intended for research and analytical applications. Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
    Terconazole (Standard)
  • HY-N13915
    Scorodonin
    		Inhibitor
    Scorodonin has anti-bacterial, Streptomyces and fungal effects. Scorodonin inhibits DNA-dependent RNA polymerases with an IC50 of 25 μg/mL.
    Scorodonin
  • HY-N14824
    Neoenactin M2
    		Inhibitor
    Neoenactin M2 has strong anti-yeastlike and filamentous fungal effects.
    Neoenactin M2
  • HY-N14560
    Cyclopaldic acid
    		Inhibitor
    Cyclopaldic acid of 2.5 μg/mL can inhibit the spore germination of Garlic botrytis spore 95%-100%.
    Cyclopaldic acid
  • HY-N4088R
    Pseudolaric acid A-O-β-D-glucopyranoside (Standard)
    Pseudolaric acid A-O-β-D-glucopyranoside (Standard) is the analytical standard of Pseudolaric acid A-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities.
    Pseudolaric acid A-O-β-D-glucopyranoside (Standard)
  • HY-124894
    (+)-Benalaxyl
    		Inhibitor
    (+)-Benalaxyl is a broad-spectrum benzamide fungicide. (+)-Benalaxyl inhibits the growth of the freshwater algae S. obliquus, with an EC50 value of 8.441 mg/L. (+)-Benalaxyl can induce the production of chlorophyll a and b, as well as increase the activity of superoxide dismutase (SOD) and the generation of malondialdehyde (MDA). (+)-Benalaxyl has inhibitory effects on catalase (CAT). (+)-Benalaxyl is effective against diseases caused by oomycetes.
    (+)-Benalaxyl
  • HY-B2051R
    Triclopyr (Standard)
    Triclopyr (Standard) is the analytical standard of Triclopyr. This product is intended for research and analytical applications. Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity.
    Triclopyr (Standard)
  • HY-N8280
    IKD-8344
    IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50=0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC=6.25 μg/mL) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.
    IKD-8344
  • HY-174353
    CYP51-IN-22
    		Inhibitor
    CYP51-IN-22 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-22 is the non-deuterated form of CYP51-IN-23-d3 (HY-174353S). CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs).
    CYP51-IN-22
  • HY-N14151
    Darlucin B
    		Inhibitor
    Darlucin B has antibacterial and fungi activity, and weak cytotoxicity.
    Darlucin B
  • HY-N14730
    De-N-methylpamamycin-593B
    De-N-methylpamamycin-593B is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593B has Aerial Mycelium-inducing activity.
    De-N-methylpamamycin-593B
  • HY-B1863
    Iprobenfos
    		Inhibitor 99.87%
    Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.
    Iprobenfos
  • HY-N15064
    Pulvilloric acid
    		Inhibitor
    Pulvilloric acid is an antifungal antibiotic found in Pen. pulvillorum 504.
    Pulvilloric acid
  • HY-N14247
    Exfoliazone
    		Inhibitor
    Exfoliazone is a phenoxazine antibiotic. Exfoliazone has the activity of resisting Valsa ceratosperma, and the ED50 that inhibits mycelial growth is 70 μg/mL.
    Exfoliazone
  • HY-B0914B
    10-Undecenoic acid (copper)
    		Inhibitor
    10-Undecenoic acid copper (Undecylenic acid copper) is an antifungal agent. 10-Undecenoic acid copper inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid copper has neuroprotective effects. 10-Undecenoic acid copper has anticancer effects on a variety of tumors. 10-Undecenoic acid copper inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid copper inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.
    10-Undecenoic acid (copper)
  • HY-N14214
    Polyoxin J
    		Inhibitor
    Polyoxin J is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin J
  • HY-B1839R
    Fluazinam (Standard)
    		Inhibitor
    Fluazinam (Standard) is the analytical standard of Fluazinam (HY-B1839). This product is intended for research and analytical applications. Fluazinam is a broad spectrum pyridinamine fungal inhibitor. Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of JNK, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees.
    Fluazinam (Standard)
  • HY-N14532
    Pyrrolomycin E
    		Inhibitor
    Pyrrolomycin E is a pyrrole antibiotic. Pyrrolomycin E has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.
    Pyrrolomycin E
  • HY-N13221
    Apple Cider Vinegar Powder
    		Inhibitor
    Apple Cider Vinegar Powder is a soluble powdered form of apple cider vinegar. Apple Cider Vinegar Powder has anti-bacterial, anti-oxidant, and antibiotic properties and can help maintain the acid-base balance in the blood. Apple Cider Vinegar Powder can lower blood sugar and lipid levels. Apple Cider Vinegar Powder is used in research related to tumors, diabetes, and cardiovascular diseases.
    Apple Cider Vinegar Powder
Cat. No. Product Name / Synonyms Application Reactivity