2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-I0626S1
    Cytosine-13C,15N2
    Cytosine-13C,15N2 is the 13C and 15N labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.
    Cytosine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-W018653R
    Cyclohexaneacetic acid (Standard)
    Naloxone (Standard) is the analytical standard of Naloxone. This product is intended for research and analytical applications. Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias.
    Cyclohexaneacetic acid (Standard)
  • HY-117275A
    Meclofenamic acid sodium hydrate
    Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively.
    Meclofenamic acid sodium hydrate
  • HY-B1092AR
    Gluconate sodium (Standard)
    Gluconate (sodium) (Standard) is the analytical standard of Gluconate (sodium). This product is intended for research and analytical applications. Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury.
    Gluconate sodium (Standard)
  • HY-16637S2
    (Rac)-Folic acid-13C5,15N
    (Rac)-Folic acid-13C5,15N is the 13C-labeled and 15N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
    (Rac)-Folic acid-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N
  • HY-W744265
    NAPQI-d3
    NAPQI-d3 (N-Acetyl-4-benzoquinone Imine-d3) is the deuterium labeled NAPQI (HY-W017464). NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.
    NAPQI-d<sub>3</sub>
  • HY-W770203
    1-Oleoyl-2-linoleoyl-rac-glycerol-d5
    1-Oleoyl-2-linoleoyl-rac-glycerol-d5 (DG(18:1/0:0/18:2)-d5) is the deuterium labeled 1-Oleoyl-2-linoleoyl-rac-glycerol (HY-W777107). 1-Oleoyl-2-linoleoyl-rac-glycerol (DG(18:1/0:0/18:2)) is a diacylglycerol, which is composed of a linoleic acid and an oleic acid. 1-Oleoyl-2-linoleoyl-rac-glycerol can be found in dry-cured ham, and acts as the food additive.
    1-Oleoyl-2-linoleoyl-rac-glycerol-d<sub>5</sub>
  • HY-169793
    Thalicpureine
    Thalicpureine (compound 12) is a secondary metabolite.
    Thalicpureine
  • HY-N2419R
    Erythrodiol (Standard)
    Erythrodiol (Standard) is the analytical standard of Erythrodiol. This product is intended for research and analytical applications. Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis.
    Erythrodiol (Standard)
  • HY-122211
    MRS2802
    MRS2802 is a P2Y14 receptor agonist with an EC50 value of 63 nM. MRS2802 can effectively activate the P2Y14 receptor and may play a role in regulating platelet function. The selectivity and activity of MRS2802 are conducive to in-depth research on the biological functions and pharmacological properties of P2Y receptors. The development of MRS2802 provides a potential inhibitory strategy for the search for new antiplatelet compounds.
    MRS2802
  • HY-13710
    Dimethindene
    Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents.
    Dimethindene
  • HY-W010735R
    ATP disodium salt hydrate (Standard)
    ATP (disodium salt hydrate) (Standard) is the analytical standard of ATP (disodium salt hydrate). This product is intended for research and analytical applications. ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation.
    ATP disodium salt hydrate (Standard)
  • HY-127038
    Diflumidone sodium
    Diflumidone sodium is a non-steroidal antiinflammatory agent.
    Diflumidone sodium
  • HY-33212R
    D-N-Acetylgalactosamine (Standard)
    D-N-Acetylgalactosamine (Standard) is the analytical standard of D-N-Acetylgalactosamine. This product is intended for research and analytical applications. D-N-Acetylgalactosamine is an endogenous metabolite.
    D-N-Acetylgalactosamine (Standard)
  • HY-125954
    Uridine diphosphate glucuronic acid
    Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum.
    Uridine diphosphate glucuronic acid
  • HY-W015851S
    3-Hydroxybutanoic acid-13C sodium
    3-Hydroxybutanoic acid-13C-13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutanoic acid-<sup>13</sup>C sodium
  • HY-W013061S10
    Propane-1,2,3-triyl tripalmitate-13C
    Propane-1,2,3-triyl tripalmitate-13C is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
    Propane-1,2,3-triyl tripalmitate-<sup>13</sup>C
  • HY-Y1373R
    Cyclohexanecarboxylic acid (Standard)
    Cyclohexanecarboxylic acid (Standard) is the analytical standard of Cyclohexanecarboxylic acid. This product is intended for research and analytical applications. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
    Cyclohexanecarboxylic acid (Standard)
  • HY-W179801
    1,3-Diphenethylurea
    		≥98.0%
    1,3-Diphenethylurea is a compound derived from marine sources, exhibiting anti-cancer activity. 1,3-Diphenethylurea has been shown to potentially inhibit tumor growth. 1,3-Diphenethylurea contributes to the development of novel therapeutic strategies in fighting cancer.
    1,3-Diphenethylurea
  • HY-126230
    PAT-494
    PAT-494 is an ATX inhibitor with significant activity in biochemical and plasma assays. PAT-494 can reduce LPA levels in rat plasma through oral administration. The structure-activity relationship study of PAT-494 shows that its binding mode with ATX is novel and it can effectively occupy the hydrophobic pockets and channels of ATX.
    PAT-494
Cat. No. Product Name / Synonyms Application Reactivity