2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

Related Products

PDF 0.7 MB

Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163847
    Anti-osteoporosis agent-9
    		Inhibitor
    Anti-osteoporosis agent-9 (compound 5b) is a N-cyclopropyl-4-((4-((4-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)methyl)benzamide derivative that shows anti-osteoclast activity.
    Anti-osteoporosis agent-9
  • HY-RS03338
    Ctsk Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsk Mouse Pre-designed siRNA Set A
  • HY-158022
    CTSL/CAPN1-IN-1
    		Inhibitor
    CTSL/CAPN1-IN-1 (compound 14a) is an oral active CTSL and CAPN1 inhibitor with the IC50  values of 3.34 nM and 375.1 nM for CTSL and CAPN1, respectively. CTSL/CAPN1-IN-1 shows anticoronaviral activity and anti-inflammatory effect.
    CTSL/CAPN1-IN-1
  • HY-152222
    SPR38
    		Inhibitor
    SPR38 is a potent SARS-CoV-2 main protease inhibitor, with a Ki of 0.260 μM. SPR38 also inhibits hCatL and hCatB, with Ki values of 1.92 μM and 11.1 μM, respectively.
    SPR38
  • HY-N12129
    6,6′-Dihydroxythiobinupharidine
    		Inhibitor
    6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively.
    6,6′-Dihydroxythiobinupharidine
  • HY-RS03332
    Ctse Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctse Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctse gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctse Mouse Pre-designed siRNA Set A
  • HY-172203
    BI-1915
    		Inhibitor
    BI-1915, a chemical probe, is the selective inhibitor for Cathepsin S with an IC50 of 17 nM. BI-1915 can be used in research of autoimmune diseases.
    BI-1915
  • HY-146580
    Cathepsin C-IN-3
    		Inhibitor
    Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC50 values of 101.5 and 86.5 nM, respectively.
    Cathepsin C-IN-3
  • HY-D0843R
    N-Ethylmaleimide (Standard)
    		Inhibitor
    Bayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition.
    N-Ethylmaleimide (Standard)
  • HY-RS03341
    Ctsl Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsl Mouse Pre-designed siRNA Set A
  • HY-P10923
    KYS-1
    KYS-1 is a selective substrate for cathepsin E with a Km value of 1.9 μM. KYS-1 was incubated with cathepsin E (1.0 ng) with the pH optimum of approximately pH 4.0.
    KYS-1
  • HY-P6293
    Heterophyllin A
    Heterophyllin A can be isolated from the aboveground parts of Elaeagnus angustifolia.
    Heterophyllin A
  • HY-10290
    MK-0674
    		Inhibitor
    MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
    MK-0674
  • HY-146649
    LmCPB-IN-1
    		Inhibitor
    LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pKi of 9.7.
    LmCPB-IN-1
  • HY-P11325
    Ac-RR-AFC TFA
    		Substrate
    Ac-RR-AFC TFA is a Cathepsin B fluorogenic substrate (Ex=400 nm, Em=505 nm). Cathepsin B activity in cells lysates is determined by measuring cleavage of Ac-RR-AFC TFA and its cleavage occurs at the RR-AFC amide bond. Ac-RR-AFC TFA can be used for activity assays and mechanistic studies on cathepsin B.
    Ac-RR-AFC TFA
  • HY-P4390
    Z-Leu-Leu-Arg-AMC
    Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S.
    Z-Leu-Leu-Arg-AMC
  • HY-P4369
    Z-Arg-Arg-AMC
    Z-Arg-Arg-AMC is a selective substrate of cathepsin B.
    Z-Arg-Arg-AMC
  • HY-152210
    ASPER-29
    		Inhibitor
    ASPER-29 is Asperphenamate HY-129578 analog. ASPER-29 also is a dual cathepsin L and S inhibitor with IC50 value of 6.03 μM and 5.02 μM, respectively. ASPER-29 can be used for the research of the migration and invasion of cancer.
    ASPER-29
  • HY-16121
    CAA-0225
    		Inhibitor
    CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].
    CAA-0225
  • HY-171888
    BI-9740
    		Inhibitor
    BI-9740 is an orally active and selective cathepsin C (CatC) inhibitor, with an IC50 of 0.6 nM in mice and 2.6 nM in rats. BI-9740 can inhibit the production of active neutrophil elastase. Additionally, BI-9740 is capable of reducing the activities of neutrophil elastase and cathepsin G in the bone marrow of rats, alleviating pathological damage to grafts after heart transplantation, shortening the reperfusion time, and improving left ventricular function. BI-9740 can be used in research related to organ transplantation.
    BI-9740
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.