2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS03332
    Ctse Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctse Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctse gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctse Mouse Pre-designed siRNA Set A
    Ctse Mouse Pre-designed siRNA Set A
  • HY-172203
    BI-1915
    		Inhibitor
    BI-1915 is the selective inhibitor for Cathepsin S with an IC50 of 17 nM. BI-1915 can be used in research of autoimmune diseases.
    BI-1915
  • HY-146580
    Cathepsin C-IN-3
    		Inhibitor
    Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC50 values of 101.5 and 86.5 nM, respectively.
    Cathepsin C-IN-3
  • HY-D0843R
    N-Ethylmaleimide (Standard)
    		Inhibitor
    Bayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition.
    N-Ethylmaleimide (Standard)
  • HY-RS03341
    Ctsl Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsl Mouse Pre-designed siRNA Set A
    Ctsl Mouse Pre-designed siRNA Set A
  • HY-P10923
    KYS-1
    KYS-1 is a selective substrate for cathepsin E with a Km value of 1.9 μM. KYS-1 was incubated with cathepsin E (1.0 ng) with the pH optimum of approximately pH 4.0.
    KYS-1
  • HY-P6293
    Heterophyllin A
    Heterophyllin A can be isolated from the aboveground parts of Elaeagnus angustifolia.
    Heterophyllin A
  • HY-10290
    MK-0674
    		Inhibitor
    MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
    MK-0674
  • HY-146649
    LmCPB-IN-1
    		Inhibitor
    LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pKi of 9.7.
    LmCPB-IN-1
  • HY-P4390
    Z-Leu-Leu-Arg-AMC
    Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S.
    Z-Leu-Leu-Arg-AMC
  • HY-P4369
    Z-Arg-Arg-AMC
    Z-Arg-Arg-AMC is a selective substrate of cathepsin B.
    Z-Arg-Arg-AMC
  • HY-152210
    ASPER-29
    		Inhibitor
    ASPER-29 is Asperphenamate HY-129578 analog. ASPER-29 also is a dual cathepsin L and S inhibitor with IC50 value of 6.03 μM and 5.02 μM, respectively. ASPER-29 can be used for the research of the migration and invasion of cancer.
    ASPER-29
  • HY-16121
    CAA-0225
    		Inhibitor
    CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].
    CAA-0225
  • HY-P10117
    Cathepsin K inhibitor 5
    		Inhibitor
    Cathepsin K inhibitor 5 is a potent Cathepsin K inhibitor.
    Cathepsin K inhibitor 5
  • HY-RS03326
    Ctsc Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsc Mouse Pre-designed siRNA Set A
    Ctsc Mouse Pre-designed siRNA Set A
  • HY-18234AR
    Leupeptin hemisulfate (Standard)
    		Inhibitor
    Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
    Leupeptin hemisulfate (Standard)
  • HY-163389
    Mpro/Cathepsin L-IN-1
    		Inhibitor
    Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 Mpro/hCatL inhibitor, with Kis of 5.54 μM and 0.701 μM respectively.
    Mpro/Cathepsin L-IN-1
  • HY-RS03324
    Ctsb Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsb Rat Pre-designed siRNA Set A
    Ctsb Rat Pre-designed siRNA Set A
  • HY-164956
    TB-9
    		Inhibitor
    TB-9, a Tasiamide B (HY-N15154) derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC50s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively.
    TB-9
  • HY-P4306
    Z-Phe-Phe-Diazomethylketone
    		Inhibitor
    Z-Phe-Phe-Diazomethylketone is a selective inhibitor of cathepsin L.
    Z-Phe-Phe-Diazomethylketone
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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