2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P4583
    Suc-Val-Pro-Phe-SBzl
    Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) is an inhibitor of CatG enzymes with IC50 values of 111-225 mM.
    Suc-Val-Pro-Phe-SBzl
  • HY-P4787
    Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2
    Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay.
    Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2
  • HY-P3012
    Cathepsin G
    		Agonist
    Cathepsin G acts as a potent agonist of human platelet activation leading to their aggregation., and can be used for screening of relevant inhibitors.
    Cathepsin G
  • HY-RS03322
    CTSB Human Pre-designed siRNA Set A
    		Inhibitor

    CTSB Human Pre-designed siRNA Set A contains three designed siRNAs for CTSB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSB Human Pre-designed siRNA Set A
    CTSB Human Pre-designed siRNA Set A
  • HY-111176
    PD 145305
    		Control
    PD 145305 (3-Phenyl-2-sulfanylpropanoic acid) is an inactive analogue of PD150606. PD150606 is a selective calpain inhibitor.
    PD 145305
  • HY-146068
    AEP-IN-1
    AEP-IN-1 (Compound 13e) is a CNS agent-like non-covalent inhibitor of asparagine endopeptidase (AEP), with the IC50 of 89 nM. AEP-IN-1 can be used for the research of numerous neurological diseases such as Alzheimer’s disease (AD).
    AEP-IN-1
  • HY-N4289R
    3-Epiursolic Acid (Standard)
    		Inhibitor
    α-Vitamin E (Standard) is the analytical standard of α-Vitamin E. This product is intended for research and analytical applications. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant.
    3-Epiursolic Acid (Standard)
  • HY-P4293
    Z-Leu-Tyr-Chloromethylketone
    Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor.
    Z-Leu-Tyr-Chloromethylketone
  • HY-P4561
    H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH
    H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis.
    H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH
  • HY-168591
    CTSC-IN-1
    		Inhibitor
    CTSC-IN-1 (B22) is a CTSC inhibitor. CTSC-IN-1 inhibits CTSC activity by binding to S2 pocket and S1 site. CTSC-IN-1 can be used in the study inflammatory bowel disease.
    CTSC-IN-1
  • HY-E70197
    Calpain-1 (pig)
    Calpain-1 (pig) (μ-Calpain) is an intracellular Ca2+-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect.
    Calpain-1 (pig)
  • HY-157477
    SARS-CoV-2 3CLpro-IN-22
    		Inhibitor
    SARS-CoV-2 3CLpro-IN-22 (Compound 17) is a cathepsin L (CTSL ) inhibitor with an IC50 value of 32.5 nM. SARS-CoV-2 3CLpro-IN-22 can be used for the study of SARS-CoV-2 virus.
    SARS-CoV-2 3CLpro-IN-22
  • HY-163842
    Cathepsin K inhibitor 7
    		Inhibitor
    Cathepsin K inhibitor 7 (compound 7) is a Cathepsin K inhibitor with the pKi of 7.3 aganist CatK. Cathepsin K inhibitor 7 can be used for study of osteoporosis.
    Cathepsin K inhibitor 7
  • HY-P4494
    Suc-Val-Pro-Phe-pNA
    Suc-Val-Pro-Phe-pNA is a substrate for cathepsin G and can be used to detect the activity of this enzyme.
    Suc-Val-Pro-Phe-pNA
  • HY-RS03327
    Ctsc Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsc Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsc Rat Pre-designed siRNA Set A
    Ctsc Rat Pre-designed siRNA Set A
  • HY-RS03330
    Ctsd Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsd Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsd Rat Pre-designed siRNA Set A
    Ctsd Rat Pre-designed siRNA Set A
  • HY-161245
    FGA146
    		Inhibitor
    FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.
    FGA146
  • HY-143714
    Cathepsin K inhibitor 2
    		Inhibitor
    Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78).
    Cathepsin K inhibitor 2
  • HY-P4302
    Z-FK-ck
    		Inhibitor
    Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) is a potent and selective gingipain-K-specific inhibitor. Z-FK-ck prolongs plasma thrombin time (TT) in a dose- and time-dependent manner.
    Z-FK-ck
  • HY-P10065
    RKLLW-NH2
    		Inhibitor
    RKLLW-NH2 is a Cathepsin L inhibitor.
    RKLLW-NH2
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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