2. Signaling Pathways
  3. GPCR/G Protein
  4. CaSR
  5. CaSR Inhibitor

CaSR Inhibitor

CaSR Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-177303
    AXT-914
    		Inhibitor
    AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research.
  • HY-103320A
    Calhex 231 hydrochloride
    		Inhibitor 99.81%
    Calhex 231 hydrochloride is a potent negative allosteric modulator that blocks (IC50 = 0.39 μM) increases in [3H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca2+-sensing receptor. Calhex 231 hydrochloride can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM).
  • HY-11095
    NPS 2390
    		Inhibitor 99.90%
    NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5. NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor.