CaMK II Inhibitor

CaMK II Inhibitors (21):

Cat. No.	Product Name	Effect	Purity

HY-15465

KN-93	Inhibitor	99.42%
KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

HY-15465B

KN-93 phosphate	Inhibitor	99.72%
KN-93 phosphate is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.

HY-N6732

K-252a	Inhibitor	99.45%
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.

HY-13290

KN-62	Inhibitor	99.45%
KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a K_i of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X₇ receptors in HEK293 cells, with an IC₅₀ value of approximately 15 nM.

HY-18271

CaMKII-IN-1	Inhibitor	98.63%
CaMKII-IN-1 is a highly selective inhibitor of CaMKII with an IC50 value of 63nM. It has almost no effect on CaMKIV, MLCK, p38a, Akt1, and PKC.

HY-N1916

Coniferyl ferulate	Inhibitor	98.73%
Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC₅₀ = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus.

HY-15465A

KN-93 hydrochloride	Inhibitor	99.64%
KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

HY-P1029

MLCK inhibitor peptide 18	Inhibitor	98.04%
MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC₅₀ of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.

HY-137506

XST-14	Inhibitor	99.26%
XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC₅₀ of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.

HY-P0214A

Autocamtide-2-related inhibitory peptide TFA	Inhibitor	99.20%
Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-P0215

Autocamtide-2-related inhibitory peptide, myristoylated	Inhibitor	98.68%
Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-Z0478

(-)-Limonene	Inhibitor	98.59%
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca²⁺) and Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture.

HY-100779

Rimacalib	Inhibitor	99.14%
Rimacalib (SMP 114) is a Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC₅₀s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ.

HY-146268

CaMKIIα-IN-1	Inhibitor	98.41%
CaMKIIα-IN-1 (Compound 4d) is an orally active Ca²⁺/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a K_D of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability.

HY-171932

CaMKIIδ-IN-1	Inhibitor
CaMKIIδ-IN-1 (compound 15e) is a pyrimidine-based inhibitor of CaMKIIδ with an IC₅₀ of 0.012 μM.

HY-W013857

Lavendustin C	Inhibitor	98.32%
Lavendustin C is a potent Ca²⁺ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC₅₀ of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC₅₀=0.012 µM) and pp60^c-src(+) kinase (IC₅₀=0.5 µM) .

HY-15720B

Glycyl H-1152 hydrochloride	Inhibitor	≥99.0%
Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC₅₀s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride.

HY-P0214

Autocamtide-2-related inhibitory peptide	Inhibitor
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-P0215A

Autocamtide-2-related inhibitory peptide, myristoylated TFA	Inhibitor
Autocamtide-2-related inhibitory peptide, myristoylated TFA is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-110140

(E)-KN-93 phosphate	Inhibitor	99.85%
(E)-KN-93 phosphate is an inhibitor for Ca²⁺/calmodulin-dependent protein kinase II (CaMK II) with IC₅₀ of 9 μM and 3 μM, for CaMKIIδ monomer and CaMKIIδ dodecamer. (E)-KN-93 phosphate binds competitively with Ca²⁺/CaM, and disrupts their interaction with CaMK II, and thus inhibits the CaMK II activation.

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