2. Signaling Pathways
  3. Immunology/Inflammation
    Metabolic Enzyme/Protease
  4. Arginase
  5. Arginase Agonist

Arginase Agonist

Arginase Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-N14001
    Naamidine J
    		Agonist
    Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors.