2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146410
    AT2R antagonist 1
    		Antagonist
    AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes.
    AT2R antagonist 1
  • HY-145611
    Mopivabil
    		Antagonist 99.66%
    Mopivabil is the antagonist of angiotensin II receptor.
    Mopivabil
  • HY-147267
    Evazarsen
    		Activator
    Evazarsen is an angiotensinogen synthesis inhibitor and possesses antihypertensive properties.
    Evazarsen
  • HY-102093A
    ZD 7155
    ZD 7155 is an AT1R selective antagonist with renal function modulating activity. The effects of ZD 7155 on glomeruli and tubules were measured in 1- (N = 9) and 6-week-old (N = 13) lambs. Pretreatment with ZD 7155 after L-NAME infusion did not alter glomerular function in 1- or 6-week-old lambs. During postnatal development, Ang II modulates the effects of NO on electrolyte handling via AT1R and AT2R. In 6-week-old lambs, selective inhibition of AT1R and AT2R increased the excretion of Na+, K+, and Cl-. In 6-week-old lambs, pretreatment with ZD 7155 and PD 123319 followed by the addition of L-NAME increased urine flow rate by 200%, free water clearance by 50%, and decreased urine osmolality by 40%. The same trends of changes in these variables were also observed when L-NAME was added to ZD 7155 or PD 123319, although to a lesser extent.
    ZD 7155
  • HY-P1792A
    Angiotensin II (1-4), human TFA
    		Agonist
    Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney.
    Angiotensin II (1-4), human TFA
  • HY-P0080A
    Novokinin TFA
    		Agonist
    Novokinin TFA is a peptide agonist of the angiotensin AT2 receptor.
    Novokinin TFA
  • HY-114953
    BMS-248360
    		Antagonist
    BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects.
    BMS-248360
  • HY-17005R
    Olmesartan medoxomil (Standard)
    		Inhibitor
    Olmesartan medoxomil (Standard) is the analytical standard of Olmesartan medoxomil. This product is intended for research and analytical applications. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
    Olmesartan medoxomil (Standard)
  • HY-15834AR
    Eprosartan mesylate (Standard)
    		Antagonist
    Eprosartan (mesylate) (Standard) is the analytical standard of Eprosartan (mesylate). This product is intended for research and analytical applications. Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively.
    Eprosartan mesylate (Standard)
  • HY-106123
    Pomisartan
    		Antagonist
    Pomisartan is an orally active angiotensin II receptor type AT1 antagonist (IC50=0.26 μM). Pomisartan works by inhibiting the binding of angiotensin II to the AT1 receptor, thereby blocking the vasoconstriction and aldosterone release caused by this interaction. Pomisartan results in a blood pressure-lowering effect.
    Pomisartan
  • HY-W140282
    Angiotensin II antipeptide
    		Inhibitor
    Angiotensin II antipeptide, a peptide, is an inverse agonist of AR1 receptor. Angiotensin II antipeptide is encoded by mRNA, complementary to that encoding Angiotensin II (HY-13948) itself.
    Angiotensin II antipeptide
  • HY-131264
    Olmesartan medoxomil impurity C
    		Antagonist
    Olmesartan medoxomil impurity C is an Olmesartan medoxomil impurity. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
    Olmesartan medoxomil impurity C
  • HY-162998
    AT2R antagonist 2
    		Antagonist
    AT2R antagonist 2 (compound I-16) is an orally active AT2R antagonist.
    AT2R antagonist 2
  • HY-17512S3
    Losartan-d2
    Losartan-d2 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
    Losartan-d<sub>2</sub>
  • HY-13955S1
    Telmisartan-d4
    		Antagonist
    Telmisartan-d4 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
    Telmisartan-d<sub>4</sub>
  • HY-145610
    Mepixetil
    		Antagonist
    Mepixetil is a potent antagonist of angiotensin II receptor.
    Mepixetil
  • HY-120776
    SC-51316
    		Antagonist
    SC-51316 is an oral active angiotensin II receptor antagonist with the IC50 values of 3.6 and 5.1 nM in rat adrenal cortical and rat uterine membrane, respectively. SC-51316 shows antihypertensive activity in vivo and in vitro.
    SC-51316
  • HY-P5123
    Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg
    		Activator
    Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Ar is a fluorogenic renin substrate  based on the N-terminal tetradecapeptide sequence of human angiotensinogen (hTDP).
    Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg
  • HY-17512S4
    Losartan-d9
    Losartan-d9 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
    Losartan-d<sub>9</sub>
  • HY-14914S1
    Azilsartan-d4
    Azilsartan-d4 is the deuterium labeled Azilsartan. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research.
    Azilsartan-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

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