2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135761
    Penconazole
    		Inhibitor 98.91%
    Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole
  • HY-10400
    Ladostigil hemitartrate
    		Inhibitor 98.90%
    Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease. Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ladostigil hemitartrate
  • HY-14566S1
    Donepezil-d5
    		Inhibitor 99.30%
    Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.
    Donepezil-d<sub>5</sub>
  • HY-116792
    Phenoxyacetone
    		Inhibitor 99.38%
    Phenoxyacetone is a acetylcholinesterase (AChE) inhibitor.
    Phenoxyacetone
  • HY-B1093
    Fenchlorphos
    		Inhibitor 99.87%
    Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction.
    Fenchlorphos
  • HY-17587S
    4-Methylbenzylidene camphor-d4
    		99.55%
    4-Methylbenzylidene camphor-d4 is the deuterium labeled 4-Methylbenzylidene camphor.
    4-Methylbenzylidene camphor-d<sub>4</sub>
  • HY-10399A
    Ladostigil hydrochloride
    		Inhibitor 99.94%
    Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease. Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ladostigil hydrochloride
  • HY-76299S
    Galanthamine-d6
    		Inhibitor 99.54%
    Galanthamine-d6 (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
    Galanthamine-d<sub>6</sub>
  • HY-149008
    α-Amylase-IN-3
    		Inhibitor 99.49%
    α-Amylase-IN-3 (Compound 4) is the inhibitor for α-Amylase, AChE and AChE with IC50s of 18.04 μM, 21.04 μM and 22.2 μM, respectively. α-Amylase-IN-3 exhibits antioxidant activity. α-Amylase-IN-3 can be used in research of diabetes and oxidative stress associated disease.
    α-Amylase-IN-3
  • HY-131413
    O-Desmethyl Galanthamine
    		Inhibitor 99.70%
    O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
    O-Desmethyl Galanthamine
  • HY-122812
    Maesopsin
    		Inhibitor 99.66%
    Maesopsin is a phenolic compound, that can be isolated from Hoveniae Lignum.
    Maesopsin
  • HY-N1089
    Vincosamide
    		Inhibitor 99.72%
    Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity.
    Vincosamide
  • HY-164130
    AChE-IN-65
    		Inhibitor
    AChE-IN-65 (Compound DABA_1) is a mixed inhibitor for acetylcholinesterase (AChE), with a Ki of 556.4 μM for Electrophorus electricus AChE.
    AChE-IN-65
  • HY-B2155
    Acotiamide monohydrochloride trihydrate
    		Inhibitor 99.79%
    Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
    Acotiamide monohydrochloride trihydrate
  • HY-B1542A
    Benactyzine hydrochloride
    		Inhibitor 99.02%
    Benactyzine hydrochloride is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine hydrochloride is an anticholinergic drug. Benactyzine hydrochloride has the potential for organophosphate poisoning research.
    Benactyzine hydrochloride
  • HY-136838
    (R)-Donepezil
    		Inhibitor 99.91%
    (R)-Donepezil is a R-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor.
    (R)-Donepezil
  • HY-B0830
    Isoprocarb
    		Inhibitor 99.12%
    Isoprocarb is carbamate insecticide that widely used to control rice paddy lice and leafhopper. Isoprocarb is also an AChE inhibitor.
    Isoprocarb
  • HY-N8161
    Kaempferol-3,7-di-O-β-glucoside
    		Inhibitor 99.59%
    Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research.
    Kaempferol-3,7-di-O-β-glucoside
  • HY-14566A
    (S)-Donepezil
    		Inhibitor
    (S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor.
    (S)-Donepezil
  • HY-I0020
    Galanthaminone
    		Inhibitor 99.85%
    Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
    Galanthaminone
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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