2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0953A
    Pipenzolate bromide
    		Antagonist
    Pipenzolate bromide is a muscarinic receptor antagonist, preventing acetyl choline from binding to the receptors.
    Pipenzolate bromide
  • HY-W049312
    7-Methoxytacrine
    		Inhibitor
    7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM, and can be used for the research of Alzheimer's disease (AD).
    7-Methoxytacrine
  • HY-170650
    SMase-IN-1
    		Inhibitor
    SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes.
    SMase-IN-1
  • HY-135761S
    Penconazole-d7
    		99.17%
    Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].
    Penconazole-d<sub>7</sub>
  • HY-W654336
    (S)-Rivastigmine-d4
    		Inhibitor
    (S)-Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    (S)-Rivastigmine-d<sub>4</sub>
  • HY-N0285R
    Imperatorin (Standard)
    		Inhibitor
    Imperatorin (Standard) is the analytical standard of Imperatorin. This product is intended for research and analytical applications. Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.
    Imperatorin (Standard)
  • HY-N13901
    Arisugacin A
    		Inhibitor
    Arisugacin A is a potent, orally active and selective acetylcholinesterase (AChE) inhibitor.
    Arisugacin A
  • HY-106016
    HP 184
    		Activator
    HP 184 is an acetylcholine release (ChE) stimulator whose ADME properties can be altered by replacing hydrogen with deuterium.
    HP 184
  • HY-N13925
    Arisugacin E
    		Control
    Arisugacin E, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin E shows no activity against AChE.
    Arisugacin E
  • HY-106412
    Stacofylline
    		Inhibitor
    Stacofylline (S 9977 free base; S 9977-2 free base) a xanthine derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities.
    Stacofylline
  • HY-124140R
    Heliosupine (Standard)
    		Inhibitor
    Heliosupine (Standard) is the analytical standard of Heliosupine. This product is intended for research and analytical applications. Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores.
    Heliosupine (Standard)
  • HY-127001
    Lycodine
    		Inhibitor
    Lycodine is a lycopodium alkaloid, which can be isolated from Huperzia saururus. Lycodine exhibits anticholinesterase activity.
    Lycodine
  • HY-B1946R
    Dimethoate (Standard)
    		Inhibitor
    Dimethoate (Standard) is the analytical standard of Dimethoate. This product is intended for research and analytical applications. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces reactive oxygen species (ROS). Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice.
    Dimethoate (Standard)
  • HY-76299R
    Galanthamine (Standard)
    		Inhibitor
    Galanthamine (Standard) is the analytical standard of Galanthamine. This product is intended for research and analytical applications. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
    Galanthamine (Standard)
  • HY-122985
    Graphislactone A
    		Inhibitor
    Graphislactone A is an antioxidant, which is found in Cephalosporium IFB-E001 and M. olivacea. Graphislactone A inhibits acetylcholinesterase (AChE) with an IC50 value of 27 μM. Graphislactone A is promising for research of oxidative damage-initiated diseases.
    Graphislactone A
  • HY-N9928
    Echinenone
    		Inhibitor
    Echinenone is an acetylcholinesterase (AChE) inhibitor (IC50=16.29 μg/mL) with anti-Aβ(25-35) activity. Echinenone can inhibit MDA content and increase superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities to cope with oxidative stress damage.
    Echinenone
  • HY-159148
    AChE-IN-70
    		Inhibitor
    AChE-IN-70 (compound 4) is a AChE inhibitor. AChE-IN-70 shows larvicidal activity against mosquito larvae (Culex pipiens L.). and can be used for study of mosquito control.
    AChE-IN-70
  • HY-W276446
    1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol
    		Inhibitor
    1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is an anticholinergic agent. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol has the potential for the research of bronchial asthma. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol
  • HY-P5797
    Fasciculin-II
    		Inhibitor
    Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE).
    Fasciculin-II
  • HY-N13928
    Arisugacin H
    		Control
    Arisugacin H, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin H shows no activity against AChE.
    Arisugacin H
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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