2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15295
    3-Acetylnerbowdine
    3-Acetylnerbowdine is an alkaloid. 3-Acetylnerbowdine can be obtained from N. bowdenii bulbs. 3-Acetylnerbowdine can be used for the study of acetylcholinesterase activity.
    3-Acetylnerbowdine
  • HY-W715341
    RO-1-5237
    RO-1-5237 is a metabolite of Pyridostigmine Bromide, which is a cholinergic and can be used for myasthenia gravis research.
    RO-1-5237
  • HY-N2912
    Axillaridine A
    		Inhibitor
    Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of AChE.
    Axillaridine A
  • HY-119772
    VU0366369
    		Modulator
    VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases.
    VU0366369
  • HY-B2155R
    Acotiamide (monohydrochloride trihydrate) (Standard)
    		Inhibitor
    Acotiamide (monohydrochloride trihydrate) (Standard) is the analytical standard of Acotiamide (monohydrochloride trihydrate). This product is intended for research and analytical applications. Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
    Acotiamide (monohydrochloride trihydrate) (Standard)
  • HY-120479
    Cythioate
    		Inhibitor
    Cythioate is an organophosphorous insecticide and anthelmintic. Cythioate is an acetylcholinesterase inhibitor which interferes with neuromuscular transmission in ectoparastites.
    Cythioate
  • HY-B1881S
    Pirimiphos-methyl-d6
    		Inhibitor
    Pirimiphos-methyl-d6 is the deuterium labeled Pirimiphos-methyl. Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains[1][2][3].
    Pirimiphos-methyl-d<sub>6</sub>
  • HY-129468
    Pirimiphos ethyl
    		Inhibitor
    Pirimiphos ethyl is a kind of organophosphorus pesticide that commonly employes for the protection of crops including vegetables, bananas, turf and mushrooms through the inhibition of acetylcholinesterase activity.
    Pirimiphos ethyl
  • HY-76299S2
    Galanthamine-d3 hydrochloride
    		Inhibitor
    Galanthamine-d3 (Galantamine-d3) hydrochloride is deuterium-labeled Galanthamine (HY-76299).
    Galanthamine-d<sub>3</sub> hydrochloride
  • HY-B1542
    Benactyzine
    		Inhibitor
    Benactyzine is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine is an anticholinergic drug. Benactyzine has the potential for organophosphate poisoning research.
    Benactyzine
  • HY-17368R
    Rivastigmine (Standard)
    		Inhibitor
    Rivastigmine (Standard) is the analytical standard of Rivastigmine. This product is intended for research and analytical applications. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    Rivastigmine (Standard)
  • HY-165600A
    Trimedoxime
    		Activator
    Trimedoxime (TMB-4) is a potent reactivator of AChE. Trimedoxime shows potency in inducing oxidative stress, with the IC50 of 22 mM.
    Trimedoxime
  • HY-N13902
    Arisugacin B
    		Inhibitor
    Arisugacin B is a potent, orally active and selective acetylcholinesterase (AChE) inhibitor.
    Arisugacin B
  • HY-17368S1
    (Rac)-Rivastigmine-d6
    		Inhibitor
    (Rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].
    (Rac)-Rivastigmine-d<sub>6</sub>
  • HY-163662
    AE027
    		Inhibitor
    AE027 is a potent inhibitor against both WT and resistant mutation F348Y AChE with the IC50 values of 10 and 43 μM, respectively.
    AE027
  • HY-134137
    Donepezil N-oxide
    		Inhibitor
    Donepezil N-oxide, a metabolite of Donepezil (HY-14566), is human erythrocyte acetylcholinesterase (AChE) inhibitor.
    Donepezil N-oxide
  • HY-N15450
    Undulatine
    		Inhibitor
    Undulatine is a potent AChE inhibitor with an IC50 of 7.4 μM. Undulatine is able to cross the BBB by passive permeation and can be used in the study of Alzheimer’s disease.
    Undulatine
  • HY-N3185
    N-Methylcalycinine
    		Inhibitor
    N-Methylcalycinine is a nature product with AChE inhibitory activity. N-Methylcalycinine can be isolated from the roots of Stephania epigaea. N-Methylcalycinine can be used for the research of asthma, cancer, dysentery, fever, hyperglycemia, intestinal complaints, inflammation, sleep disturbances, tuberculosis and so on.
    N-Methylcalycinine
  • HY-100919R
    Ambenonium chloride (Standard)
    		Inhibitor
    Ambenonium (chloride) (Standard) is the analytical standard of Ambenonium (chloride). This product is intended for research and analytical applications. Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE).
    Ambenonium chloride (Standard)
  • HY-N15323
    Samioside
    		Inhibitor
    Samioside is an effective acetylcholinesterase inhibitor that can be isolated from Phlomis nissolii and P. capitata. Samioside possesses free-radical scavenging and antimicrobial activities. Samioside can be used in research on its anti-Alzheimer’s potency.
    Samioside
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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