2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

Related Products

PDF 2.56 MB

Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149484
    AChE/BChE-IN-15
    		Inhibitor
    AChE/BChE-IN-15 (Compound 6d) is an AChE/BChE inhibitor, with IC50s of 20 nM and 220 nM respectively. AChE/BChE-IN-15 binds to both catalytic anionic site (CAS) and peripheral anionic site (PAS) in the active sites of AChE and BChE. AChE/BChE-IN-15 can be used for research of Alzheimer’s disease.
    AChE/BChE-IN-15
  • HY-127165
    Velnacrine
    		Inhibitor
    Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg.
    Velnacrine
  • HY-157520
    BChE-IN-25
    		Inhibitor
    BChE-IN-25 (compound 4I) is a selective BChE inhibitor (IC50: 3.77μM), which is 22 times more selective for BChE than AChE.
    BChE-IN-25
  • HY-155473
    Phosphatidylcholine transfer protein inhibitor-2
    		Inhibitor 98.14%
    Phosphatidylcholine transfer protein inhibitor-2 (answer 41) is a inhibitor of phosphatidylcholine transfer protein.
    Phosphatidylcholine transfer protein inhibitor-2
  • HY-169961
    BChE-IN-38
    		Inhibitor
    BChE-IN-38 (compound 13) is a potent BChE inhibitor with Ki values of 62.05, 28.78, 14.09, 1.15 nM for hCAI, hCAII, AChE, BChE, respectively. BChE-IN-38 shows cytotoxic activity.
    BChE-IN-38
  • HY-150585
    BuChE-IN-5
    		Inhibitor
    BuChE-IN-5 (compound 25b) is a potent BuChE inhibitor with an IC50 value of 1.94 μM. BuChE-IN-5 efficiently inhibits aggregation Aβ and tau protein in Escherichia coli. BuChE-IN-5 also has free radical scavenging capacity and antioxidant activity. BuChE-IN-5 can be used for researching Alzheimer’s disease.
    BuChE-IN-5
  • HY-116153
    HUHS2002
    HUHS2002 is a free fatty acid derivative with the ability to enhance α7 cholinergic receptor activity. HUHS2002 enhances whole-cell membrane currents of α7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner. The effects of HUHS2002 were blocked in the presence of the Ca2 /calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. HUHS2002 activated CaMKII in cultured rodent hippocampal neurons, and this activation was abolished by KN-93. HUHS2002 also partially inhibited the activity of protein phosphatase 1 (PP1) in a cell-free PP1 activity assay.
    HUHS2002
  • HY-161243
    AChE-IN-56
    		Inhibitor
    AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy.
    AChE-IN-56
  • HY-159133
    BuChE-IN-13
    		Inhibitor
    BuChE-IN-13 (compound 3) is a BuChE inhibitor and shows anti-Alzheimer activity. BuChE-IN-13 can be used for study of neurodegenerative disease.
    BuChE-IN-13
  • HY-B0207AS1
    Pyridostigmine-d3 bromide
    		Inhibitor
    Pyridostigmine-d3 (bromide) is the deuterium labeled Pyridostigmine bromide. Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.
    Pyridostigmine-d<sub>3</sub> bromide
  • HY-A0009R
    Galanthamine (hydrobromide) (Standard)
    		Inhibitor
    Galanthamine (hydrobromide) (Standard) is the analytical standard of Galanthamine (hydrobromide). This product is intended for research and analytical applications. Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).
    Galanthamine (hydrobromide) (Standard)
  • HY-105790
    Piperilate
    Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates.
    Piperilate
  • HY-169156
    HDAC6-IN-49
    		Inhibitor
    HDAC6-IN-49 (Compound 3) is an inhibitor for HDAC with IC50 of 0.012 and 0.735 μM for HDAC6 and HDAC1. HDAC6-IN-49 also exhibits inhibitory activities against MAO-B, cholinesterase (ChE), histamine receptor (H3R) and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective efficacy on SH-SY5Y cell. HDAC6-IN-49 improves cognitive function and locomotor ability in Drosophila Parkinson's disease models and in C. elegans Alzheimer's disease models.
    HDAC6-IN-49
  • HY-170691
    hAChE/hBuChE-IN-1
    		Inhibitor
    hAChE/hBuChE-IN-1 (compound C2) is a dual inhibitor of cholinesterase with IC50 values of 514 nM and 358 nM for hAChE and hBuChE respectively. hAChE/hBuChE-IN-1 has oral activity and improves cognition and spatial memory.
    hAChE/hBuChE-IN-1
  • HY-149288
    hAChE/hBACE-1-IN-2
    		Inhibitor
    hAChE/hBACE-1-IN-2 is a potent, orally active, blood-brain barrier transboundary triple inhibitor of hAChE, hBChE, and HACE-1 with IC50s of 0.113 μM, 1.48 μM and 0.38 μM, respectively. hAChE/hBACE-1-IN-2 has antioxidant activity. hAChE/hBACE-1-IN-2 also inhibits Aβ11-42 aggregation. hAChE/hBACE-1-IN-2 can be used to study Alzheimer's disease.
    hAChE/hBACE-1-IN-2
  • HY-RS00156
    ACHE Human Pre-designed siRNA Set A
    		Inhibitor

    ACHE Human Pre-designed siRNA Set A contains three designed siRNAs for ACHE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ACHE Human Pre-designed siRNA Set A
    ACHE Human Pre-designed siRNA Set A
  • HY-162338
    BChE-IN-29
    		Inhibitor
    BChE-IN-29 (Compound 27a) is a BChE inhibitor (IC50: 0.078 μM and 0.74 μM for BChE and AChE respectively). BChE-IN-29 has anti-inflammatory activity and can be used for research of AD.
    BChE-IN-29
  • HY-156030
    AChE-IN-40
    		Inhibitor
    AChE-IN-40 (Compound 5C) is an AChE inhibitor (IC50: 120 nM). AChE-IN-40 can be used for research of Alzheimer's disease.
    AChE-IN-40
  • HY-161058
    AChE-IN-49
    		Inhibitor
    AChE-IN-49 (Compd (S)-7g) is an acetylcholinesterase (AChE) inhibitor, with an IC50 of 0.0003 μM.
    AChE-IN-49
  • HY-117633
    Sultroponium
    		Inhibitor
    Sultroponium (A118) is an anticholinergic agent.
    Sultroponium
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.