1. Signaling Pathways
  2. Neuronal Signaling
  3. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157437
    AChE/BChE-IN-16
    Inhibitor
    AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC50s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H2O2-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS).
    AChE/BChE-IN-16
  • HY-121467
    Acotiamide
    Inhibitor 99.92%
    Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
    Acotiamide
  • HY-144389
    hAChE/Aβ1-42-IN-1
    Inhibitor
    hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD).
    hAChE/Aβ1-42-IN-1
  • HY-B0949A
    Protriptyline
    Inhibitor
    Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease.
    Protriptyline
  • HY-146665
    AChE/BChE-IN-5
    Inhibitor
    AChE/BChE-IN-5 (BMC-16) is a dual AChE and BChE inhibitor with IC50 values of 266 nM and 10.6 nM against human AChE (hAChE) and human BChE (hBChE), respectively. AChE/BChE-IN-5 can cross the BBB.
    AChE/BChE-IN-5
  • HY-157089
    AChE/MAO-B-IN-5
    Inhibitor
    AChE/MAO-B-IN-5 is a dual inhibitor of AChE and MAO-B. AChE/MAO-B-IN-5 can used in study Alzheimer’s disease.
    AChE/MAO-B-IN-5
  • HY-170560
    AChE/hCA I-IN-1
    Inhibitor
    AChE/hCA I-IN-1 (Compound L3) is the inhibitor for acetylcholinesterase (AChE) and carbonic anhydrase (CA), that inhibits AChE, hCA I and hCA II with IC50 of 302, 265 and 283 nM, respectively.
    AChE/hCA I-IN-1
  • HY-156031
    BChE-IN-19
    Inhibitor
    BChE-IN-19 (Compound 7b) is a para-substituted derivative of indone (7b) with inhibitory activity of butyryl cholinesterase (BChE) (IC50=0.04 μM). BChE-IN-19 improves cholinergic scheduling in the nervous system. BChE-IN-19 can be used against Alzheimer's disease.
    BChE-IN-19
  • HY-B0034R
    Donepezil Hydrochloride (Standard)
    Inhibitor
    Donepezil (Hydrochloride) (Standard) is the analytical standard of Donepezil (Hydrochloride). This product is intended for research and analytical applications. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity.
    Donepezil Hydrochloride (Standard)
  • HY-N0804A
    Isonaringin
    Inhibitor
    Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
    Isonaringin
  • HY-147733
    sEH inhibitor-5
    Inhibitor
    sEH inhibitor-5 (compound D016) is a potent sEH (soluble epoxide hydrolase) inhibitor with an IC50 value of 0.1 nM.
    sEH inhibitor-5
  • HY-146762
    MAO-B-IN-7
    Inhibitor
    MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. MAO-B-IN-7 can effectively alleviate oxidative stress and neuroinflammatory damage.
    MAO-B-IN-7
  • HY-N0804AR
    Isonaringin (Standard)
    Inhibitor
    Isonaringin (Standard) is the analytical standard of Isonaringin. This product is intended for research and analytical applications. Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
    Isonaringin (Standard)
  • HY-118533A
    Ambenonium dichloride tetrahydrate
    Inhibitor
    Ambenonium (WIN 8077) dichloride tetrahydrate is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium dichloride tetrahydrate inhibits human AChE with an IC50 value of 0.7 nM (hAChE).
    Ambenonium dichloride tetrahydrate
  • HY-157440
    AChE/Aβ-IN-3
    Inhibitor
    AChE/Aβ-IN-3 (compound AM5) is a dual inhibitor of AChE and Amyloid-β aggregation with IC50<.sub> values of 1.29 and 4.93 μM, respectively. AChE/Aβ-IN-3 has antioxidant properties that scavenge ROS and restore their normal levels. AChE/Aβ-IN-3 can be used in the study of neurological diseases, such as Alzheimer's disease.
    AChE/Aβ-IN-3
  • HY-149012
    AChE/hCA I/II-IN-1
    Inhibitor
    AChE/hCA I/II-IN-1 (Compound 6) is a potent inhibitor of AChE/Hca with IC50 values of 22.21, 60.79 and 66.64 nM for AChE, Hca Ⅰ and Hca Ⅱ. AChE/hCA I/II-IN-1 can be used for the rsearch for glaucoma, Alzheimer's disease, diabetes.
    AChE/hCA I/II-IN-1
  • HY-152632
    BuChE-IN-7
    Inhibitor
    BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC50 values of 40 nM, 80 nM respectively. BuChE-IN-7 can promote cognitive with blood-brain penetration and improves situational and phobic memory, showing preference for new things.
    BuChE-IN-7
  • HY-144446
    BuChE-IN-1
    Inhibitor
    BuChE-IN-1 (Compound 23) is a potent inhibitor of butyrylcholinesterase (BuChE). Butyrylcholinesterase (BuChE) is recently regarded as a biomarker in progressed Alzheimer’s disease (AD). BuChE-IN-1 shows low cytotoxicity and high blood brain barrier (BBB) permeability. BuChE-IN-1 is a promising BuChE inhibitor for the research of AD.
    BuChE-IN-1
  • HY-144762
    K027
    Inhibitor
    K027 is a potent reactivator of Organophosphates (OP)-inhibited acetylcholinesterase (AChE). K027 can be used for the research of Alzheimer's disease.
    K027
  • HY-155086
    hAChE-IN-4
    Inhibitor
    hAChE-IN-4 (Compd 5d) is a potent, blood-brain barrier-permeable hAChE inhibitor with IC50 of 0.25 μM. hAChE-IN-4 can be used in Alzheimer's disease research.
    hAChE-IN-4
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