2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-159482
    SBN-284
    		Inhibitor
    SBN-284 (compound 3x) is a dual inhibitor of blood-brain permeable Cholinesterases and the NLRP3 inflammasome and is effective against EeAChE, hAChE and eqBChE, the IC50 values of are 0.37, 0.31, 0.29 μM respectively, and the EC50 of NLRP3 inflamm is 1 μM. SBN-284 can be used in Alzheimer's disease research.
    SBN-284
  • HY-172461
    MAO-IN-6
    		Inhibitor
    MAO-IN-6 (Compound 3f) is a BBB permeable and reversible MAO-B inhibitor with an IC50 of 0.09 μM. MAO-IN-6 also exhibits certain inhibitory activities against AChE and BChE, with IC50 values of 4.48 μM and 17.03 μM, respectively. MAO-IN-6 has low cytotoxicity and can be used in the research of Alzheimer's disease.
    MAO-IN-6
  • HY-151260
    AChE/BACE1/GSK3β-IN-1
    		Inhibitor
    AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC50 values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD).
    AChE/BACE1/GSK3β-IN-1
  • HY-155345
    AChE-IN-45
    		Inhibitor
    AChE-IN-45 (Compound 14) is an acetylcholinesterase (AChE) inhibitor with IC50 of 11.57±0.45 nM that shows antioxidant and neuroprotective activities.
    AChE-IN-45
  • HY-155368
    BChE-IN-20
    		Inhibitor
    BChE-IN-20 (compound 7c) is a highly potent BChE-selective inhibitor and exhibits IC50s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC50 of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes.
    BChE-IN-20
  • HY-N0923R
    Corydaline (Standard)
    		Inhibitor
    Corydaline (Standard) is the analytical standard of Corydaline. This product is intended for research and analytical applications. Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
    Corydaline (Standard)
  • HY-152109
    AChE/MAO-IN-1
    		Inhibitor
    AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC50s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively.
    AChE/MAO-IN-1
  • HY-N10490
    Blestrin D
    		Inhibitor
    Blestrin D is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC50 value of 8.1 μM. Blestrin D can be isolated from Bletilla striata. Blestrin D can be used for the research of Alzheimer's disease (AD).
    Blestrin D
  • HY-144316
    ZLWH-23
    		Inhibitor
    ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease.
    ZLWH-23
  • HY-163175
    BChE-IN-24
    		Inhibitor
    BChE-IN-24 is a selective and reversible BChE inhibitor with an IC50 of 9 nM. BChE-IN-24 can be used for the research of Alzheimer’s disease and related neurodegenerative disorders.
    BChE-IN-24
  • HY-101981S5
    Uridine 5'-monophosphate-15N2 dilithium
    		Activator 98.00%
    Uridine 5'-monophosphate-15N2 (5'- Uridylic acid-15N2) dilithium is 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
    Uridine 5'-monophosphate-<sup>15</sup>N<sub>2</sub> dilithium
  • HY-150728
    AChE-IN-22
    		Inhibitor
    AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC50 values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease.
    AChE-IN-22
  • HY-155733
    AChE/Aβ-IN-1
    		Inhibitor
    AChE/Aβ-IN-1 (compound 32) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 3.876 μM. AChE/Aβ-IN-1 also inhibits Aβ aggregation and shows good blood-brain barrier permeability and neuroprotection. AChE/Aβ-IN-1 improves cognitive and spatial memory impairment in rats model.
    AChE/Aβ-IN-1
  • HY-175524
    BChE/MAO-B-IN-2
    		Inhibitor
    BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD).
    BChE/MAO-B-IN-2
  • HY-107805
    Dihydroactinidiolide
    		Inhibitor
    Dihydroactinidiolide, existing in plant leaves and fruits, is a potent plant growth inhibitor, a regulator of gene expression and is responsible for photo acclimation in Arabidopsis. Dihydroactinidiolide has antioxidant activity, antibacterial activity, anticancer activity and neuroprotective effect. Dihydroactinidiolide is also an inhibitor of AChE (IC50=34.03 nM) and has scavenging activities for DPPH and (.NO). Dihydroactinidiolide is present in plant leaves and fruits and is a potent plant growth inhibitor, regulator of gene expression, and responsible for light adaptation in Arabidopsis.
    Dihydroactinidiolide
  • HY-116574
    Leiokinine A
    		Inhibitor
    Leiokinine A is a 4-quinolinone alkaloid and can be isolated from Esenbeckia leiocarpa.
    Leiokinine A
  • HY-132904
    eeAChE-IN-2
    		Inhibitor
    eeAChE-IN-2 is a potent eeAChE inhibitor with an IC50 value of 2 nM.
    eeAChE-IN-2
  • HY-157437
    AChE/BChE-IN-16
    		Inhibitor
    AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC50s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H2O2-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS).
    AChE/BChE-IN-16
  • HY-121467
    Acotiamide
    		Inhibitor 99.92%
    Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
    Acotiamide
  • HY-144389
    hAChE/Aβ1-42-IN-1
    		Inhibitor
    hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD).
    hAChE/Aβ1-42-IN-1
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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