2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

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Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162830
    5-LOX/MAOs-IN-1
    		Inhibitor
    5-LOX/MAOs-IN-1 (compound 3) is a 5-LOX/MAOs inhibitor and a potent free radical scavenger with antioxidant properties. 5-LOX/MAOs-IN-1 also showed neuroprotective activity in oxidative stress-damaged cell models and can activate the neurogenesis microenvironment of adult mouse neural stem cells. 5-LOX/MAOs-IN-1 can be used for the study of neurodegenerative diseases.
    5-LOX/MAOs-IN-1
  • HY-121124
    Fluindione
    		Inhibitor
    Fluindione is a inhibitor of 5-lipoxygenase with the IC50 of 15 μM. Fluindione has antiinflammatory activity.
    Fluindione
  • HY-155160
    COX-2/15-LOX-IN-3
    		Inhibitor
    COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity.
    COX-2/15-LOX-IN-3
  • HY-N13132
    Hellicoside
    		Inhibitor
    Hellicoside is a natural product that can be obtained from plantain. Hellicoside has inhibitory activity against cAMP phosphodiesterase and 5-lipoxygenase.
    Hellicoside
  • HY-116919
    MLS000536924
    		Inhibitor
    MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity.
    MLS000536924
  • HY-138148
    13(S)-HPOTrE(γ)
    13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE.2 At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.
    13(S)-HPOTrE(γ)
  • HY-121931
    AA863
    AA863 is a 5-lipoxygenase inhibitor with activity in inhibiting the proliferation of human glioma cells. AA863 exhibits significant and dose-dependent inhibitory effects in monolayer cultured glioma cells with an IC50 of 9.0 micromolar.
    AA863
  • HY-165049
    1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol
    		Substrate
    1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol (1-Stearin-2-olein-3-linolein), a compound in the triglyceride composition of ostrich oil, was analyzed and identified by specific chromatography-mass spectrometry techniques.
    1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol
  • HY-P10458
    5-Lipoxygenase blocking peptide
    		Inhibitor
    5-Lipoxygenase blocking peptide (Human/rat 5-LO 130-149) is a specific sequence fragment of 5-lipoxygenase (5-LOX), which can be utilized to prepare an antibody against 5-LOX.
    5-Lipoxygenase blocking peptide
  • HY-N2513R
    β-Boswellic acid (Standard)
    		Inhibitor
    β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells.
    β-Boswellic acid (Standard)
  • HY-175275
    10-Butyl Ether Minocycline
    		Inhibitor
    10-Butyl Ether Minocycline (BEM), a Minocycline (HY-17412A) derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 µM and 47.0 µM, respectively. 10-Butyl Ether Minocycline suppresses LPS (HY-D1056)-induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine (HY-N0390)-induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder (AUD).
    10-Butyl Ether Minocycline
  • HY-175970
    MLS000099089
    		Inhibitor
    MLS000099089 is a 12/15-lipoxygenase (12/15-LOX) inhibitor with IC50 values of 3.4 μM and 10 μM for human and mice 12/15-LOX, respectively. MLS000099089 displays higher selectivity for 12/15-LOX over 5-LOX and COX-2. MLS000099089 can be used for the study of stroke.
    MLS000099089
  • HY-U00024A
    Enazadrem phosphate
    		Inhibitor
    Enazadrem phosphate is an effective 5-lipoxygenase inhibitor with anti-inflammatory effects.
    Enazadrem phosphate
  • HY-19221
    Bay-y-1015
    		Inhibitor
    Bay-y-1015 is an orally active quinoline-based 5-lipoxygenase inhibitor. Bay-y-1015 inhibits LTB4 and LTC4 synthesis. Bay-y-1015 can be used in the research of inflammatory diseases.
    Bay-y-1015
  • HY-149476
    5-LOX-IN-5
    		Inhibitor
    5-LOX-IN-5 (Compound 29) is a 5-LOX inhibitor (IC50: 56 nM). 5-LOX-IN-5 can be used for research of neurodegenerative diseases.
    5-LOX-IN-5
  • HY-150191
    IMA-1
    IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1). IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH.
    IMA-1
  • HY-150548
    COX-2/15-LOX-IN-1
    		Inhibitor
    COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity.
    COX-2/15-LOX-IN-1
  • HY-N7156
    2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
    		Inhibitor
    2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone, isolated from Parinari hypochrysea (Chrysobalanaceae), exhibits antioxidant and lipoxygenase inhibition.
    2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
  • HY-138979
    Lipoxygenin
    		Inhibitor
    Lipoxygenin is a non-redox 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. Lipoxygenin modulates the β-catenin-5-LO complex, inducing a decrease in β-catenin and 5-LO levels in the nucleus.
    Lipoxygenin
  • HY-116866
    Sclerotiorin
    		Inhibitor
    Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
    Sclerotiorin
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

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