2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. γ-Glutamyl Transferase (GGT)
  5. γ-Glutamyl Transferase (GGT) Inhibitor

γ-Glutamyl Transferase (GGT) Inhibitor

γ-Glutamyl Transferase (GGT) Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-108467
    GGsTop
    		Inhibitor 99.35%
    GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model.
  • HY-W016586
    Acivicin
    		Inhibitor 99.00%
    Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.
  • HY-128350A
    FGTI-2734 mesylate
    		Inhibitor 99.65%
    FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.
  • HY-126710
    OU749
    		Inhibitor 98.83%
    OU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a Ki value of 17.6 µM. OU749 shows cytotoxicity.
  • HY-154996
    Gamma-Glutamyl Transferase-IN-2
    		Inhibitor
    Gamma-Glutamyl Transferase-IN-2 (compound 4dq) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-2 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.
  • HY-W016586R
    Acivicin (Standard)
    		Inhibitor
    Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway.
  • HY-154993
    Gamma-Glutamyl Transferase-IN-1
    		Inhibitor
    Gamma-Glutamyl Transferase-IN-1 (compound 4de) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-1 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.
  • HY-W142025
    6-Diazo-5-oxo-D-norleucine
    		Inhibitor
    6-Diazo-5-oxo-D-norleucine, a D-Glutamine (HY-100587) analog, is a γ-glutamyl transferase inhibitor.
  • HY-W016586AR
    Acivicin hydrochloride (Standard)
    		Inhibitor
    Acivicin (hydrochloride) (Standard) is the analytical standard of Acivicin (hydrochloride). This product is intended for research and analytical applications. Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].