2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105157
    Icopezil 145508-78-7 98%
    Icopezil is a selective acetylcholinesterase (AchE) inhibitor. Icopezil can be used in Alzheimer's disease research.
    Icopezil
  • HY-105161
    AP-521 free base 151227-58-6 98%
    AP-521 (free base) is a benzothienopyridine derivative that exhibits potent anxiolytic effects by acting as a postsynaptic 5-HT1A receptor agonist and by enhancing serotonergic neural transmission in the medial prefrontal cortex (mPFC). AP-521 (free base) is promising for research of anxiety disorders.
    AP-521 free base
  • HY-105192
    CP-122288 143321-74-8 98%
    CP-122288, a highly potent inhibitor of neurogenic inflammation, can be used in migraine study.
    CP-122288
  • HY-105226
    CI-988 130332-27-3 98%
    CI-988 (PD134308) is a potent, selective and orally active CCK2R (cholecystokinin 2 receptor) antagonist with an IC50 of 1.7 nM for mouse cortex CCK2. CI-988 shows >1600-fold selectivity for CCK2 over CCK1 receptor. CI-988 has anxiolytic and anti-tumor effects.
    CI-988
  • HY-105235
    Enadoline 124378-77-4 98%
    Enadoline (CI-977) is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects.
    Enadoline
  • HY-105236
    (Rac)-Enadoline 107431-28-7 98%
    (Rac)-Enadoline ((Rac)-CI-977 free base) is a selective K-opioid receptor agonist that stereoselectively antagonizes clonic seizures induced by slow intravenous injection of N-methyl-DL-aspartate in mice.
    (Rac)-Enadoline
  • HY-105238
    JHU-75528 947696-17-5 98%
    JHU-75528 is a novel ligand of the cannabinoid receptor (CB1). JHU-75528 can be used in the research of imaging CB1 receptor.
    JHU-75528
  • HY-105253
    PARP-2/1-IN-2 912444-01-0 98%
    PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity.
    PARP-2/1-IN-2
  • HY-105435
    FR121196 133920-65-7 98%
    FR121196 is a cognitive enhancer, and ameliorates Scopolamine (HY-N0296)-induced memory deficit. FR121196 is an antidementia compound.
    FR121196
  • HY-105436
    FR 113680 126088-92-4 98%
    FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor.
    FR 113680
  • HY-105485
    FR-62765 105346-34-7 98%
    FR-62765 is a derivative of WF-3681. FR-62765 can significantly inhibit the accumulation of sorbitol in the sciatic nerve and the decrease of motor nerve conduction velocity in the tail of diabetic neuropathy rats, which can be used in the research of diabetic neuropathy.
    FR-62765
  • HY-105534
    TAK-637 217185-75-6 98%
    TAK-637 is an orally active neurokinin-1 receptor antagonist. TAK-637 increases bladder storage capacity. TAK-637 can be used for research of functional bowel diseases such as irritable bowel syndrome.
    TAK-637
  • HY-105569
    Amphotalide 1673-06-9 98%
    Amphotalide is an anticonvulsant.
    Amphotalide
  • HY-105604
    Anilopam 53716-46-4 98%
    Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.
    Anilopam
  • HY-10560A
    Temanogrel hydrochloride 957466-27-2 98%
    Temanogrel hydrochloride is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
    Temanogrel hydrochloride
  • HY-105616
    Roflurane 679-90-3 98%
    Roflurane (DA 893) is a halocarbon agent that can relieve pain.
    Roflurane
  • HY-105631
    Hydroxytetracaine 490-98-2 98%
    Hydroxytetracaine is a local agent that can suppress or relieve pain.
    Hydroxytetracaine
  • HY-105652
    Ambucetamide 519-88-0 98%
    Ambucetamide is an antispasmodic agent. Ambucetamide alleviates menstrual pain.
    Ambucetamide
  • HY-10570S
    Nevirapine-d4 1051418-95-1 98%
    Nevirapine-d4 is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM.
    Nevirapine-d4
  • HY-105738
    Butaverine 55837-14-4 98%
    Butaverine is an antispasmodic compound.
    Butaverine
Cat. No. Product Name / Synonyms Application Reactivity