2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W654098
    Cefazolin-13C2,15N sodium 1346602-30-9 98%
    Cefazolin-13C2,15N (sodium) is 13C and 15N labeled Cefazolin (sodium). Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research. Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD).
    Cefazolin-13C2,15N sodium
  • HY-W654121
    p-Cresol sulfate-d4 potassium 98%
    p-Cresol sulfate-d4 (potassium) is deuterium labeled p-Cresyl sulfate (potassium). p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.
    p-Cresol sulfate-d4 potassium
  • HY-W654227
    7-Hydroxy methotrexate-d3 ammonium salt 98%
    7-Hydroxy methotrexate-d3 (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    7-Hydroxy methotrexate-d3 ammonium salt
  • HY-W654334
    9-cis-Retinol-d5 98%
    9-cis-Retinol-d5 is deuterium labeled 9-cis Retinol. 9-cis Retinol is a precursor of 9-cis-Retinal (HY-W009310). 9-cis Retinol can inhibit 9-cis-Retinoic acid (HY-15128) synthesis in Hep G2 cells.
    9-cis-Retinol-d5
  • HY-W700620
    Hydroxymethyl dasatinib 910297-58-4 99.92%
    Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells.
    Hydroxymethyl dasatinib
  • HY-W703279
    (R)-(+)-Pantoprazole sodium 160098-11-3 98%
    (R)-(+)-Pantoprazole ((R)-(+)-BY1023) sodium is a proton pump inhibitor that can be used for the study of gastroesophageal reflux disease.
    (R)-(+)-Pantoprazole sodium
  • HY-W703540
    Deracoxib-d4 1794780-24-7 98%
    Deracoxib-d4 (SC 046-d4) is deuterium labeled Deracoxib.
    Deracoxib-d4
  • HY-W704772
    S-Methyl-D-penicillamine 29913-84-6 98%
    S-Methyl-D-penicillamine is a metabolite of the chelating agent Penicillamine (HY-B0300).
    S-Methyl-D-penicillamine
  • HY-W706470
    (-)-Bornyl ferulate 55511-07-4 98%
    (-)-Bornyl ferulate is a 5-lipoxygenase and COX inhibitor with IC50s of 10.4 μM and 12.0 μM, respectively.
    (-)-Bornyl ferulate
  • HY-W708469
    Resolvin D2 methyl ester 810668-53-2 98%
    Resolvin D2 methyl ester is an ester derivative of the DHA (HY-B2167) metabolite Resolvin D2 (HY-121636) with anti-inflammatory and anti-infective activities. Resolvin D2 is a leukocyte modulator and a potent inhibitor of neuronal TRPV1 (IC50=0.1 nM) and TRPA1 (IC50=2 nM). Resolvin D2 can be used in sepsis research.
    Resolvin D2 methyl ester
  • HY-W709553
    Glyceryl Triformate 32765-69-8 98%
    Glyceryl Triformate (Triglyceride) is the major form of storage and transport of fatty acids within cells and in the plasma. Glyceryl Triformate forms lipoproteins with cholesterol ester, and participates in the blood circulation. Glyceryl Triformate can lead to hypertriglyceridemia (HTG), which increases the risk of atherosclerotic cardiovascular disease (ASCVD) and pancreatitis.
    Glyceryl Triformate
  • HY-W709961
    5-OAHSA 1997286-66-4 98%
    5-OAHSA (1-(3-Carboxypropyl)tetradecyl (9Z)-9-octadecenoate) is a endogenous lipid. 5-OAHSA reduces the level of blood glucose, improves the glucose tolerance, and stimulates the the secretion of GLP-1 and insulin. 5-OAHSA exhibits potential in regulating metabolic and inflammatory responses.
    5-OAHSA
  • HY-W710753
    D,L-Sulforaphane glutathione-d5 98%
    D,L-Sulforaphane glutathione-d5 (DL-SFN-GSH-d5) is deuterium labeled DL-Sulforaphane glutathione. DL-Sulforaphane glutathione (DL-SFN-GSH) is a metabolite of Sulforaphane (HY-13755) in rat plasma.
    D,L-Sulforaphane glutathione-d5
  • HY-W714076
    Ametoctradin 865318-97-4 98%
    Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews.
    Ametoctradin
  • HY-W721656
    Triclacetamol 6340-87-0 98%
    Triclacetamol is the trichloroacetyl derivative of Acetaminophen (HY-66005), exhibiting weak cyclooxygenase inhibition and possessing analgesic and antipyretic activities as a nonsteroidal anti-inflammatory drug (NSAID). Triclacetamol acts as an anti-inflammatory agent and promotes the excretion of uric acid.
    Triclacetamol
  • HY-W739793
    Pantoprazole-d8 sodium 98%
    Pantoprazole-d8 (BY1023-d8) sodium is a deuterium labeled Pantoprazole (HY-17507). Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142).
    Pantoprazole-d8 sodium
  • HY-W740028
    Cefditoren-d3 sodium 98%
    Cefditoren-d3 (sodium) (ME 1206-d3) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
    Cefditoren-d3 sodium
  • HY-W740175
    6b-Hydroxy triamcinolone acetonide 3869-32-7 98%
    6b-Hydroxy triamcinolone acetonide is a metabolite of the synthetic corticosteroid Triamcinolone acetonide (HY-B0636). 6b-Hydroxy triamcinolone acetonide is formed from triamcinolone acetonide by the cytochrome P450 (CYP) isoforms CYP3A4, CYP3A5, and CYP3A7.
    6b-Hydroxy triamcinolone acetonide
  • HY-W740572
    O-Desmethyl-N-deschlorobenzoyl Indomethacin 50995-53-4 98%
    O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin (HY-14397). It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandin D2 (HY-101988) receptor antagonists.
    O-Desmethyl-N-deschlorobenzoyl Indomethacin
  • HY-W741999
    Metaproterenol-d7-1 hemisulfate 98%
    Metaproterenol-d7-1 (hemisulfate) is deuterium labeled Metaproterenol (hemisulfate). Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity.
    Metaproterenol-d7-1 hemisulfate
Cat. No. Product Name / Synonyms Application Reactivity