2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-171470
    RS-57067 179382-91-3 98%
    RS-57067 is a COX-2 inhibitor with a Ki of 16.9 μM. RS-57067 reduces the production of prostaglandins (such as PGE2) by inhibiting COX-2, thereby alleviating the inflammatory response. RS-57067 can be used in the research of inflammatory and immune diseases.
    RS-57067
  • HY-171476
    CP-865569 478833-25-9 98%
    CP-865569 is a CCR1 antagonist. CP-865569 can be used in the research of inflammatory diseases and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.
    CP-865569
  • HY-171829
    Ergothioneine sulfonate 1651182-16-9
    Ergothioneine sulfonate is a sulfonated derivative of ergothioneine (HY-N1914) with antioxidant activity. Ergothioneine sulfonate is converted to a stable sulfonic acid form via a redox reaction. Ergothioneine sulfonate can be used to study the disease mechanisms associated with inflammation and oxidative stress.
    Ergothioneine sulfonate
  • HY-172163
    FITC-dextran sulfate (MW 4kDa) 98%
    FITC-dextran sulfate, 4kDa is a sodium dextran sulfate labeled with FITC, with an average molecular weight of 4 kDa.
    FITC-dextran sulfate (MW 4kDa)
  • HY-172167
    PD-L1/HDAC-IN-1 2923313-69-1 98%
    PD-L1/HDAC-IN-1 (Compound 14) is the inhibitor for PD-L1 and HDAC that inhibits PD-1/PD-L1 interaction, HDAC2 and HDAC3 with IC50 of 88.10, 27.98 and 14.47 nM, respectively. PD-L1/HDAC-IN-1 exhibits slight cytotoxicity in MCF-7 (IC50=19.34 μM). PD-L1/HDAC-IN-1 upregulates the expression of PD-L1 and CXCL10, promoting anti-tumour immune response by recruiting T-cell infiltration into TME.
    PD-L1/HDAC-IN-1
  • HY-172195
    FS-694 1417404-27-3 98%
    FS-694 is the inhibitor for p38α with an IC50 of 0.2 nM. FS-694 inhibits the TNFα release in human whole blood with an IC50 of 35.0 nM.
    FS-694
  • HY-173077
    PD-L1/LpxC-IN-1 98%
    PD-L1/LpxC-IN-1 (Conpound 12b) is the inhibitor for PD-L1 and LpxC with IC50 of 5.2 μM and 0.081 μM. PD-L1/LpxC-IN-1 inhibits the biosynthesis of bacterial lipopolysaccharide, causes the lysis and death of bacterial cells. PD-L1/LpxC-IN-1 inhibits Gram-negative bacteria, MIC for K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028 and P. aeruginosa ATCC 9027 is 0.25-0.5 μg/mL. PD-L1/LpxC-IN-1 downregulates the expression of inflammatory factors IL-2 and IFN-γ, upregulates the expression of CD4+ and CD8+ cells, thereby activating the immune system and inhibiting excessive inflammatory responses. PD-L1/LpxC-IN-1 exhibits antibacterial activity in K. pneumoniae ATCC 13883 infected mouse models.
    PD-L1/LpxC-IN-1
  • HY-173189
    2-5A 65954-93-0 98%
    2-5A is a 5'-triphosphorylated (2',5') oligoadenylate. 2-5A is an immunotransmitter that fuels RNase L immunity. 2-5A degrades viral mRNA and inhibits protein synthesis by binding to RNase L and activating its endoribonuclease activity. 2-5A can be used in RSV and cancer research.
    2-5A
  • HY-173204
    Influenza virus-IN-9 98%
    Influenza virus-IN-9 (12) is an influenza endonuclease inhibitor, with an IC50 of 0.03 μM.
    Influenza virus-IN-9
  • HY-173213
    Antileishmanial agent-33 98%
    Antileishmanial agent-33 (4e), a hybrid compound of grandisin and machilin G, shows moderate activity on promastigotes (IC50 of 38.1 μM). Antileishmanial agent-33 (4e) shows potential as an antileishmanial agent for the research of cutaneous leishmaniasis (CL).
    Antileishmanial agent-33
  • HY-173215
    3-Dimethylaminopropyl deacetylforskolin 98%
    3-Dimethylaminopropyl deacetylforskolin is a dehydro derivative of adenylate cyclase activator Forskolin (HY-15371) and may cause cross-immunoreactivity with anti-Forskolin antibodies.
    3-Dimethylaminopropyl deacetylforskolin
  • HY-173285
    SARS-CoV-2 Mpro-IN-38 98%
    SARS-CoV-2 Mpro-IN-38 (2-5a) is a SARS-CoV‑2 Mpro inhibitor, with an IC50 of 0.0435 μM.
    SARS-CoV-2 Mpro-IN-38
  • HY-173298
    PDHK1-IN-2 2870691-38-4 98%
    PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinases 1/2 (PDHK1/2), with an IC50 of 0.007 μM for PDHK1 and an IC50 of 0.015 μM for PDHK2. PDHK1-IN-2 can regulate immune cell metabolism and correct mitochondrial dysfunction, and is expected to be used in the research of autoimmune diseases, inflammatory diseases, cancers, and other conditions.
    PDHK1-IN-2
  • HY-173301
    PDHK1-IN-3 98%
    PDHK1-IN-3 (Compound 29) is a selective PDHK1 inhibitor with an IC50 of 0.028 μM against PDHK1 and an IC50 of 0.120 μM against PDHK2. PDHK1-IN-3 inhibits the activity of PDHK1 by forming a covalent bond with Lys299 in PDHK1. PDHK1-IN-3 can be used in the research of autoimmune diseases, inflammatory diseases, and cancer.
    PDHK1-IN-3
  • HY-173332
    15-LOX-1 inhibitor 2 98%
    15-LOX-1 inhibitor 2 (Compound 5i) is an inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 1.7 μM. 15-LOX-1 inhibitor 2 inhibits the activity of 15-LOX-1 enzyme, reduces the production of lipid peroxides, thereby inhibiting lipid peroxidation and protecting cells from cell death induced by RSL3 (HY-100218A). 15-LOX-1 inhibitor 2 can be used in research on cell death mechanisms, oxidative stress-related diseases and other fields.
    15-LOX-1 inhibitor 2
  • HY-173356
    Antiparasitic agent-26 98%
    Antiparasitic agent-26 (Compound 8) is an antiparasitic compound that potently inhibits the growth of Naegleria fowleri, with IC50 values of 22.87 μM (trophozoite stage) and 25.16 μM (cyst stage). Antiparasitic agent-26 exerts its antiparasitic activity by inducing programmed cell death, including cytoplasmic calcium accumulation, mitochondrial membrane potential collapse, ATP synthesis inhibition, ROS accumulation, and chromatin condensation. Antiparasitic agent-26 can be used in the research of primary amoebic meningoencephalitis (PAM).
    Antiparasitic agent-26
  • HY-173388
    TLR4-IN-2 1019984-44-1 98%
    TLR4-IN-2 (Compound Racemic-11k) is inhibitors of TLR4, JNK, and NF-κB. TLR4-IN-2 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 23.2 µM. TLR4-IN-2 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB, blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4-IN-2 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders.
    TLR4-IN-2
  • HY-173417
    Antibacterial agent 275 98%
    Antibacterial agent 275 (Ⅲ1) is a antibacterial agent, with a λmax of 730 nm. Antibacterial agent 275 (Ⅲ1) can be used in the research for antimicrobial photodynamic therapy (aPDT).
    Antibacterial agent 275
  • HY-173485
    SARS-CoV-2 Mpro-IN-41 98%
    SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor of COX-2 and SARS-CoV-2 M pro (IC50 values are 9.66 μM and 13.24 μM, respectively). SARS-CoV-2 Mpro-IN-41 also has a certain inhibitory activity against COX-1 (IC50: 46.11 μM). SARS-CoV-2 Mpro-IN-41 can significantly inhibit the expression of inflammatory-related cytokines (such as TNF-α, IL-6, IL-1β) and exert anti-inflammatory effects. SARS-CoV-2 Mpro-IN-41 exerts anti-inflammatory and antiviral effects by selectively inhibiting COX-2 and SARS-CoV-2 M pro. SARS-CoV-2 Mpro-IN-41 can be used for anti-inflammatory and anti-coronavirus research.
    SARS-CoV-2 Mpro-IN-41
  • HY-17357R
    Nepafenac (Standard) 78281-72-8
    Nepafenac (Standard) is the analytical standard of Nepafenac. This product is intended for research and analytical applications. Nepafenac (AHR 9434; AL 6515; Nevanac) is a COX-2 inhibitor and the original drug of Amfenac.
    Nepafenac (Standard)
Cat. No. Product Name / Synonyms Application Reactivity