2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-125412
    Fasciculic acid B 126882-55-1 98%
    Fasciculic acid B is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
    Fasciculic acid B
  • HY-125434
    Laccaic acid B 17249-00-2 98%
    Laccaic acid B, a natural compound that can be isolated from Kerria and Paratachardina genera, possesses antioxidant activity.
    Laccaic acid B
  • HY-125522
    Methyl helicterate 102637-02-5 98%
    Methyl helicterate is a triterpenoid, that can be isolated from Helicteres angustifolia (Sterculiaceae). Methyl helicterate inhibits hepatic stellate cell activation and promotes cell apoptosis through downregulating the ERK1/2 signaling pathway.
    Methyl helicterate
  • HY-125670
    Lanceolarin 15914-68-8 98%
    Lanceolarin is an isoflavone compound isolated from the Andira inermis plant with anti-inflammatory, antioxidant and anti-tumor activities.
    Lanceolarin
  • HY-125922
    (22R)-Budesonide 51372-29-3 98%
    (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity.
    (22R)-Budesonide
  • HY-125971
    Xylopropamine hydrobromide 861007-60-5 98%
    Xylopropamine hydrobromide is an analgesic compound.
    Xylopropamine hydrobromide
  • HY-126184
    Revatropate 149926-91-0 98%
    Revatropate is an antimuscarinic compound. Revatropate has a much greater inhibitory effect on M1 and M3 receptors than on the M2 subtype. Revatropate is used in the study of urge urinary incontinence and functional bowel disorders.
    Revatropate
  • HY-126211
    KBH-A42 798543-50-7 98%
    KBH-A42 is a novel histone deacetylase (HDAC) inhibitor with significant anti-inflammatory properties. KBH-A42 against TNF-α and NO production with IC50 values of 1.10 and 2.71 µM, respectively, in the LPS-induced murine macrophage RAW 264.7 cells.
    KBH-A42
  • HY-12642R
    Diethylcarbamazine citrate (Standard) 1642-54-2
    Diethylcarbamazine (citrate) (Standard) is the analytical standard of Diethylcarbamazine (citrate). This product is intended for research and analytical applications. Diethylcarbamazine citrate is an orally active anthropoidal compound. Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism of filaria microfilaria. Diethylcarbamazine citrate has anti-inflammatory and antiparasitic activity.
    Diethylcarbamazine citrate (Standard)
  • HY-126560
    F-Amidine 877617-45-3 98%
    F-Amidine is a Protein arginine deiminase 4 (PAD4) inhibitor. F-Amidine can be used in the study of inflammatory and immune system diseases (such as rheumatoid arthritis).
    F-Amidine
  • HY-126758
    Ludartin 36149-87-8 98%
    Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury.
    Ludartin
  • HY-126984
    Fanetizole mesylate 79069-95-7 98%
    Fanetizole mesylate is an anti-inflammatory agent. Fanetizole mesylate can be used for inflammatory diseases research.
    Fanetizole mesylate
  • HY-127110
    AK106-001616 590416-75-4 98%
    AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis.
    AK106-001616
  • HY-127166
    Colchiceine 477-27-0 98%
    Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis.
    Colchiceine
  • HY-12740R
    Lotamilast (Standard) 947620-48-6
    Lotamilast (Standard) is the analytical standard of Lotamilast. This product is intended for research and analytical applications. Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
    Lotamilast (Standard)
  • HY-12789R
    Etrasimod (Standard) 1206123-37-6
    Etrasimod (Standard) is the analytical standard of Etrasimod. This product is intended for research and analytical applications. Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells.
    Etrasimod (Standard)
  • HY-12789S
    Etrasimod-d9 98%
    Etrasimod-d9 (APD334-d9) is a deuterium labeled Etrasimod (HY-12789). Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells..
    Etrasimod-d9
  • HY-12815R
    MCC950 (Standard) 210826-40-7
    MCC950 (Standard) is the analytical standard of MCC950. This product is intended for research and analytical applications. MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
    MCC950 (Standard)
  • HY-128221
    SGK1-IN-5 1426214-51-8 98%
    SGK1-IN-5 (Compound 1) is an inhibitor for serum and glucocorticoid regulated kinase SGK 1 with an IC50 of 3 nM. SGK1-IN-5 inhibits SGK-1 dependent phosphorylation of GSK3β in U2OS cells with an IC50 of 1.4 μM. SGK1-IN-5 can be used in research about osteoarthritis or rheumatism.
    SGK1-IN-5
  • HY-128403
    BTK inhibitor 8 2230724-66-8 98%
    BTK inhibitor 8 (Compound 27) is a Btk inhibitor with an IC50 of 0.11 nM. BTK inhibitor 8 inhibits B cell activation in hWB with an IC50 of 2 nM.
    BTK inhibitor 8
Cat. No. Product Name / Synonyms Application Reactivity