2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111473
    Anti-inflammatory agent 82 178408-16-7 98%
    Anti-inflammatory agent 82 has potential analgesic and anti-inflammatory effects.
    Anti-inflammatory agent 82
  • HY-111811
    Homomangiferin 21794-66-1 98%
    Homomangiferin is mangiferin monomethyl ether. Homomangiferin has important medicinal properties and is widely used to relieve many symptoms, for example coughing and asthma.
    Homomangiferin
  • HY-112333
    SC-68376 318480-82-9 98%
    SC-68376 is a potent, reversible, ATP-competitive, and selective inhibitor of p38 MAP kinase inhibitor.
    SC-68376
  • HY-112650
    12-OxoETE 108437-64-5 98%
    12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence.
    12-OxoETE
  • HY-112863
    RORγt inhibitor 3 1361413-10-6 98%
    RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models.
    RORγt inhibitor 3
  • HY-113018
    Ibuprofen acyl-β-D-glucuronide 115075-59-7 98%
    Ibuprofen acyl-β-D-glucuronide (Ibuprofen glucuronide) is a selective TRPA1 antagonis. Ibuprofen acyl-β-D-glucuronide reduces AITC-evoked calcium response with an IC50 value of 60μM.
    Ibuprofen acyl-β-D-glucuronide
  • HY-113149
    Argininosuccinic acid 2387-71-5 98%
    Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc.
    Argininosuccinic acid
  • HY-113628
    ABT-080 189498-57-5 98%
    ABT-080 is an orally active inhibitor of leukotriene biosynthesis. ABT-080 simultaneously blocks the leukotriene pathways leading to the synthesis of LTB4 and LTC4, but does not inhibit PGH2 biosynthesis. ABT-080 can block bronchoconstriction and be used in the research of asthma and related inflammations
    ABT-080
  • HY-113635
    ONO-6240 99659-62-8 98%
    ONO-6240 is a platelet-activating factor antagonist. ONO-6240 prevents EOS infiltration into airway. ONO-6240 can be used in the study of asthmatic.
    ONO-6240
  • HY-113669
    A-940894 1027330-82-0 98%
    A-940894 is a potent histamine H4 receptor antagonist, with Ki values of 7.6 nM (rat H4) and 71 nM (human H4). A-940894 exhibits with anti-inflammatory properties.
    A-940894
  • HY-113721
    BML-244 104062-70-6 98%
    BML-244 is a potent cathepsin K inhibitor. BML-244 can be used in the study of rheumatoid arthritis (RA) and periodontitis.
    BML-244
  • HY-113807
    ZLJ-6 1051931-39-5 98%
    ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC50 values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity.
    ZLJ-6
  • HY-113913
    12(S)-HPEPE 103239-14-1 98%
    12(S)-HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12(S)-HPEPE reduces interleukin 1h (IL-1h)-induced PGHS-2 expression in human lung microvascular endothelial cells.
    12(S)-HPEPE
  • HY-114602
    AR-C117977 216685-07-3 98%
    AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse.
    AR-C117977
  • HY-114689
    Diclofenac methyl ester 15307-78-5
    Diclofenac methyl ester is a metabolite of Diclofenac (HY-15036), which exhibits acute cytotoxicity with a LC50 of 0.5 mg/L in H. azteca.
    Diclofenac methyl ester
  • HY-114700
    ZINC08438472 443872-20-6 98%
    ZINC08438472 is a potent and selective peroxisome proliferator activated receptors-α (PPAR-α) agonist with an EC50 value of 12.1 nM. ZINC08438472 is promising for research of diabetes, hyperlipidaemia and inflammatory disorders.
    ZINC08438472
  • HY-114724
    HSR-609 161522-25-4 98%
    HSR-609 is an orally active amphoteric antiallergic agent. HSR-609 has a high affinity for histamine H1-receptor in the guinea pig cerebral cortex. HSR-609 inhibits allergic airway hyperresponsiveness to Acetylcholine. HSR-609 shows poor ability to penetrate into the CNS in mice and guinea pigs.
    HSR-609
  • HY-114730
    CGA-JK3 1621626-06-9 98%
    CGA-JK3 is CGA-JK3 is an ATP-competitive inhibitor of IKKβ-catalyzed kinase activity. CGA-JK3 inhibits IκBα phosphorylation in LPS (HY-D1056) - induced RAW 264.7 cells.
    CGA-JK3
  • HY-114830
    Fenleuton 141579-54-6 98%
    Fenleuton is a 5-lipoxygenase inhibitor. Fenleuton is promising for research of leukotriene-mediated inflammatory diseases.
    Fenleuton
  • HY-114860
    LY 215891 68403-79-2 98%
    LY 215891 (compound 6a) exhibits potent Gram-positive and Gram-negative antibacterial activity with MICs of 0.015 μg/mL and 0.06 μg/mL for Klebsiella pneumoniae X26 and Escherichia coli EC14, respectively.
    LY 215891
Cat. No. Product Name / Synonyms Application Reactivity