2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N16371
    6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid 39051-96-2
    6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid (Compound MC-1), an isocoumarin, is a metabolite of Cytogenin (HY-19606). 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid has anti-angiogenic activity in S-180 implanted dorsal air sac mice model. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid also modifies collagen-induced arthritis. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid can be used for cancers and inflammatory diseases research.
    6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid
  • HY-N16372
    Pronqodine A 1424195-39-0
    Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation.
    Pronqodine A
  • HY-N16376
    Thienodolin 149127-27-5 98%
    Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation.
    Thienodolin
  • HY-N16408
    Berkeleyamide B 1019854-22-8
    Berkeleyamide B is a dual matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide B is promising for research of cancers and inflammatory disease (e.g., rheumatoid arthritis).
    Berkeleyamide B
  • HY-N16409
    Berkeleyamide C 1019854-23-9
    Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases.
    Berkeleyamide C
  • HY-N16415
    Deoxyfunicone 137461-36-0 98%
    Deoxyfunicone is a secondary fungal metabolite that inhibits PTP1B activity by binding to the active site of the enzyme with an IC50 value of 24.3µM. Deoxyfunicone has anti-inflammatory activity.
    Deoxyfunicone
  • HY-N16431
    NFAT-133 165133-85-7
    NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056).
    NFAT-133
  • HY-N16450
    Cnidilide 3674-03-1 98%
    Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS (HY-D1056). Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions.
    Cnidilide
  • HY-N16464
    Desglucoruscin 39491-37-7 98%
    Desglucoruscin (Ruscoponticoside C) is a hydrolysis product of steroid glycosides ruscin and ruscoside. Steroid glycosides ruscin and ruscoside is found in Ruscus aculeatus L. with anti-inflammation effect. Steroid glycosides ruscin and ruscoside can be used as a laxative or diuretic and can remove kidney stones.
    Desglucoruscin
  • HY-N16465
    Cinnamtannin D1 97233-06-2
    Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA).
    Cinnamtannin D1
  • HY-N16467
    Uncarine F 14019-66-0 98%
    Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease.
    Uncarine F
  • HY-N16469
    Ruscin 39491-41-3 98%
    Ruscin (Ruscoponticoside D; Neoruscine) is steroidal saponin found in Butcher’s Broom. Ruscin has multiple bioactivities and possesses a variety of pharmacological activities, including anti-inflammatory properties, platelet aggregation inhibition, pulmonary hypertension lowering properties, acute lung injury alleviation.
    Ruscin
  • HY-N16473
    14,15-Epoxyazadiradione 58525-91-0
    14,15-Epoxyazadiradione is a triterpenoid found in Azadirachta indica. Azadirachta indica shows anti-infection, anti-inflammatory and anticancer activities. Azadirachtin H can be used for the researches of cancer, infection and inflammation.
    14,15-Epoxyazadiradione
  • HY-N16474
    Azadirachtin H 134788-15-1 98%
    Azadirachtin H is a triterpenoid found in Azadirachta indica. Azadirachta indica shows anti-infection, anti-inflammatory and anticancer activities. Azadirachtin H can be used for the researches of cancer, infection and inflammation.
    Azadirachtin H
  • HY-N16480
    Lindetannin 651750-97-9 98%
    Lindetannin (Lindetannin trimer) is an A-type trimer of proanthocyanidin (HY-N0794) found in the bark of Cinnamomum trees. Proanthocyanidin are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancer agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy.
    Lindetannin
  • HY-N16481
    Parameritannin A-1 347406-26-2
    Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A2 (PLA2).
    Parameritannin A-1
  • HY-N16482
    Cassiatannin A 1206883-80-8
    Cassiatannin A is a tetramer of proanthocyanidin (HY-N0794) found in Cinnamomum cassia. Cassiatannin A shows COX-2 inhibitor activity with inhibition rate of 38, 52 and 97% at 10, 100 and 1000 μg/mL. Cassiatannin A can be used for the research of inflammation.
    Cassiatannin A
  • HY-N16579
    (+)-Catechin 3-O-β-D-glucopyranoside 109280-46-8
    (+)-Catechin 3-O-β-D-glucopyranoside (Compound 13) is an anti-allergic agent found in Edulis Superba. (+)-Catechin 3-O-β-D-glucopyranoside can be used for the research of inflammation and immunology.
    (+)-Catechin 3-O-β-D-glucopyranoside
  • HY-N16626
    Chantriolide B 558470-60-3
    Chantriolide B is a new withanolide glucoside. Chantriolide B can be isolated from the rhizomes of Tacca chantrieri. Chantriolide B does not inhibit NO in cells.
    Chantriolide B
  • HY-N16634
    30-Hydroxyquinoa-saponin 1 898565-67-8 98%
    30-Hydroxyquinoa-saponin 1 is one of the components of mixed saponins. 30-Hydroxyquinoa-saponin 1 can be used for research on inflammatory conditions.
    30-Hydroxyquinoa-saponin 1
Cat. No. Product Name / Synonyms Application Reactivity