2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W701470
    W140 hydrobromide 1246817-25-3 98%
    W140 hydrobromide is a S1P1 antagonist with the Ki of 2.84 μM, and can enhanceof capillary leakage and restoration of lymphocyte egress.
    W140 hydrobromide
  • HY-W702634
    Butibufen-d5 1346603-83-5 98%
    Butibufen-d5 is the deuterium labeled Butibufen (HY-121132). Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
    Butibufen-d5
  • HY-W703632
    2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol 1794979-83-1 98%
    2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol is the deuterium labeled Ibuprofen alcohol (HY-131261). Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).
    2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol
  • HY-W704363
    Pimozide-d5 1794979-08-0 98%
    Pimozide-d5 (R6238-d5) is the deuterium labeled Pimozide (HY-12987). Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
    Pimozide-d5
  • HY-W704787
    Monoethyl fumarate-d5 1266398-64-4 98%
    Monoethyl fumarate-d5 is the deuterium labeled Monoethyl fumarate (HY-W019696). Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883). Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material.
    Monoethyl fumarate-d5
  • HY-W705168
    Yangonin-d3 106324-70-3 98%
    Yangonin-d3 is the deuterium labeled Yangonin (HY-N0919). Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.
    Yangonin-d3
  • HY-W707407
    Bisoprolol-d7 1310012-16-8 98%
    Bisoprolol-d7 is deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.
    Bisoprolol-d7
  • HY-W707656
    Aspirin-d7 98%
    Aspirin-d7 is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
    Aspirin-d7
  • HY-W707708
    N-(4-Ethoxyphenyl)acetamide-2,2,2-d3 60902-27-4 98%
    N-(4-Ethoxyphenyl)acetamide-2,2,2-d3 is the deuterium labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats.
    N-(4-Ethoxyphenyl)acetamide-2,2,2-d3
  • HY-W709055
    Pantoprazole sulfone-d6 (major) 98%
    Pantoprazole sulfone-d6 (major) is the deuterium labeled Pantoprazole sulfone (HY-117225). Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor Pantoprazole (HY-17507).
    Pantoprazole sulfone-d6 (major)
  • HY-W709349
    Flupirtine hydrochloride 33400-45-2 98%
    Flupirtine hydrochloride (D 9998 hydrochloride) is a selective neuropotassium channel opener with analgesic activity. Flupirtine hydrochloride is used to inhibit a variety of pain conditions, including chronic musculoskeletal pain, migraines, and neuralgia. Flupirtine hydrochloride has antidepressant and antioxidant properties and may increase the analgesic effect in combination therapy with morphine. Flupirtine hydrochloride relieves abnormally increased muscle tension and has a muscle relaxant effect. Flupirtine hydrochloride is clinically superior to other drugs, such as tramadol and pantoxan, plus its side effects are better tolerated. Flupirtine hydrochloride has a significant effect on inhibiting neural hyperexcitability and therefore exhibits inhibitory potential in various pain states.
    Flupirtine hydrochloride
  • HY-W709448
    Oxaprozin-d10 98%
    Oxaprozin-d10 (Oxaprozinum-d10; Wy21743-d10) is the deuterium labeled Oxaprozin (HY-B0808). Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
    Oxaprozin-d10
  • HY-W713010
    3-Epideoxycholic acid-d5 98%
    3-Epideoxycholic acid-d5 is the deuterium labeled 3-Epideoxycholic acid (HY-48814). 3-Epideoxycholic acid is the microbial metabolite of Deoxycholic acid (HY-N0593). 3-Epideoxycholic acid targets FXR of dendritic cells, reduces their immunostimulatory properties, promotes the generation of Treg cells, and exhibits anti-inflammatory activity. 3-Epideoxycholic acid promotes the growth of bacteria Bacteroides.
    3-Epideoxycholic acid-d5
  • HY-W714529
    Digoxigenin-d3 127299-96-1 98%
    Digoxigenin-d3 (Lanadigenin-d3) is the deuterium labeled Digoxigenin (HY-B1025). Digoxigenin (DIG) is a steroid. DIG is used for situ hybridization as a labeling molecule probe due to long shelf life and fast detection and high sensitivity of DIG-labeled riboprobes.
    Digoxigenin-d3
  • HY-W716702
    Aldox-d6 2469039-16-3 98%
    Aldox-d6 (Lexamine M-13-d6; MAPD-d6) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .
    Aldox-d6
  • HY-W721119
    7-Methylsulfinylheptyl isothiocyanate 129244-98-0 98%
    7-Methylsulfinylheptyl isothiocyanate is an activator for MAPK signaling pathway, which downregulates the melanogenesis related proteins and suppresses the melanin synthesis in B16-F1 cells. 7-Methylsulfinylheptyl isothiocyanate induces autophagy. 7-Methylsulfinylheptyl isothiocyanate is an inducer for phase II enzyme, which exhibits chemoprotective effect against carcinogen. 7-Methylsulfinylheptyl isothiocyanate can be used as cosmetic ingredient for skin whitening and anti-inflammation.
    7-Methylsulfinylheptyl isothiocyanate
  • HY-W722562
    Trimethylamine oxide-15N 98%
    Trimethylamine oxide-15N is the deuterium labeled Trimethylamine N-oxide (HY-116084). Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
    Trimethylamine oxide-15N
  • HY-W725543
    Chlorphenesin-d5 98%
    Chlorphenesin-d5 is the deuterium labeled Chlorphenesin (HY-A0133). Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics.
    Chlorphenesin-d5
  • HY-W728545
    Labetalol-d6 hydrochloride 98%
    Labetalol hydrochloride-d6 (AH-5158 hydrochloride-d6) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy.
    Labetalol-d6 hydrochloride
  • HY-W738273
    Veratric acid-13C 90140-57-1 98%
    Veratric acid-13C (3,4-Dimethoxybenzoic acid-13C) is the 13C-labeled Veratric acid (HY-N2007). Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
    Veratric acid-13C
Cat. No. Product Name / Synonyms Application Reactivity