2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-123637
    Autotaxin-IN-1 1619971-30-0 98%
    Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
    Autotaxin-IN-1
  • HY-123638
    6-Hydroxykaempferol 3,6,7-tri-O-β-D-glucoside 145134-62-9 98%
    6-hydroxykaempferol 3,6,7-tri-O-β-D-glucoside is a bio-active flavonoid from Carthamus tinctorius with antioxidant capacities in vitro.
    6-Hydroxykaempferol 3,6,7-tri-O-β-D-glucoside
  • HY-123639
    LM-4108 261766-32-9
    LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively.
    LM-4108
  • HY-123642
    BLXA-4-ME 362516-29-8 98%
    BLXA-4-ME is used for gingivitis study.
    BLXA-4-ME
  • HY-123679
    FR168888 168620-46-0 98%
    FR168888 is an inhibitor of Na+/H+ exchange with a Ki value of 6.4 nM.
    FR168888
  • HY-123691
    7-O-Demethyl rapamycin 151519-50-5 98%
    7-O-Demethyl rapamycin, a derivative of Rapamycin (HY-10219), has antifungal activity and immunosuppressant properties. 7-O-Demethyl rapamycin has useful tumor cell growth-inhibiting activity.
    7-O-Demethyl rapamycin
  • HY-123693
    ML358 1158607-44-3 98%
    ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics.
    ML358
  • HY-12369A
    GGTI-2133 TFA 1217480-14-2 98%
    GGTI-2133 TFA, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC50 of 38 nM. GGTI-2133 TFA shows 140-fold selectivity over farnesyltransferase (FTase) (IC50 of 5.4 μM). GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC50 of 10 μM. GGTI-2133 TFA can be used for the study of eosinophilic airway inflammation such as asthma.
    GGTI-2133 TFA
  • HY-123787
    MK-1029 1242273-04-6 98%
    MK-1029 is a DP2 antagonist. MK-1029 can be used in research on respiratory diseases such as asthma.
    MK-1029
  • HY-123791
    AZD-9819 956907-23-6 98%
    AZD-9819 is a neutrophil elastase (HNE) inhibitor. AZD-9819 can be used to study chronic obstructive pulmonary disease.
    AZD-9819
  • HY-123829
    LY2624803 879409-35-5 98%
    LY2624803 is a 5-HT2A and histamine, H1 receptor antagonist.
    LY2624803
  • HY-12383S
    Pelubiprofen-13C,d3 98%
    Pelubiprofen-13C,d3 is the 13C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
    Pelubiprofen-13C,d3
  • HY-123862
    LAS195319 1605328-04-8 98%
    LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
    LAS195319
  • HY-123876
    AS2677131 2171502-44-4 98%
    AS2677131 is a potent and orally active PIKfyve inhibitor. AS2677131 inhibits f IL-12p40, IL-6 and IL-1β through a PIKfyve-c-Rel pathway. AS2677131 selectively inhibits DNA-binding activity of c-Rel to IL-12p40 and IL-1β promoter. AS2677131 inhibits MHC class II expression on B cells. AS2677131 can be used for the researches of inflammation and immunology, such as arthritis.
    AS2677131
  • HY-123878
    DS79182026 2113642-80-9 98%
    DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model.
    DS79182026
  • HY-123924
    CSLP37 2244984-64-1 98%
    CSLP37 is a selective RIPK2 inhibitor with an IC50 of 16.3 nM. CSLP37 shows no inhibitory activity against RIPK1 and RIPK3. CSLP37 displays potent suppression of cellular NOD1 and NOD2 responses.
    CSLP37
  • HY-123956
    HG-12-6 2222354-57-4 98%
    HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation.
    HG-12-6
  • HY-123970
    ISO-92 899433-49-9 98%
    ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research.
    ISO-92
  • HY-124040
    BI-1950 1159724-42-1 98%
    BI-1950, a chemical probe, is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor. LFA-1 is an essential component in normal immune system function and a target for agent discovery.
    BI-1950
  • HY-124065
    ARRY-502 1202891-16-4 98%
    ARRY-502 is an orally active, potent and selective CRTh2 antagonist. ARRY-502 blocks PGD2-mediated Th2 inflammation (e.g., eosinophil activation, airway hyperresponsiveness). ARRY-502 is promising for research of Th2-related asthma.
    ARRY-502
Cat. No. Product Name / Synonyms Application Reactivity