2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105480
    SKF 104351 111908-94-2 98%
    SKF 104351 is an orally active cytokine suppressive anti-inflammatory drug. SKF 104351 can inhibit TNF-α production.
    SKF 104351
  • HY-105483
    MDL 43291 129357-91-1 98%
    MDL 43291 is a competitive leukotriene (LT) receptor antagonist. MDL 43291 antagonize LTD4 and LTE4 with pA2 of 6.7. MDL 43291 does not antagonize histamine, carbachol or substance P. MDL 43291 can be used for the researches of inflammation and immunology, such as asthma.
    MDL 43291
  • HY-105488
    MDL 201112 142130-73-2 98%
    MDL 201112 is a carbocyclic nucleoside. MDL 201112 can decrease TNF-α production and inhibit MHC class II Ia+ antigen expression. MDL 201112 can be used for the research of inflammation and immunology.
    MDL 201112
  • HY-105504
    CI-986 130116-16-4 98%
    CI-986 is a dual inhibitor of COX and 5-LOX. CI-986 can prevent the coronary vasoconstriction and the increased production of LTB(4) and LTC(4). CI-986 also has anti-inflammatory and analgesic effects. CI-986 can be used for the researches of inflammation and cardiovascular disease, such as arthritis.
    CI-986
  • HY-105507
    PF-10040 132928-46-2 98%
    PF-10040 is a quinoline derivative that can inhibit PAF-induced airway hyperresponsiveness. PF-10040 also shows protective effect in experimental NSAID-gastritis.
    PF-10040
  • HY-105520
    ORG-20241 145261-31-0 98%
    ORG-20241 is a PDE3/PDE4 dual inhibitor. ORG-20241 has a significant bronchodilator effect and completely prevents allergen induced airway hyperresponsiveness. ORG-20241 can significantly inhibit eosinophil infiltration at high concentrations. ORG-20241 can be used for research on asthma.
    ORG-20241
  • HY-105579
    Isonixin 57021-61-1 98%
    Isonixin (Isonixine) is a non-steroidal compound. Isonixin can be used for the research of pain and inflammation.
    Isonixin
  • HY-105630
    Pipebuzone 27315-91-9 98%
    Pipebuzone (LD 4644) is an anti-inflammatory, antipyretic and analgesic agent. Pipebuzone plays an important raol in rheumatic diseases.
    Pipebuzone
  • HY-105641
    Morazone 6536-18-1 98%
    Morazone is a non-steroidal anti-inflammatory drug (NSAID).
    Morazone
  • HY-105667
    Butanixin 55285-35-3 98%
    Butanixin (2-[(4-Butylphenyl)amino]-3-pyridinecarboxylic acid) is a cyclooxygenase (COX) inhibitor. It exerts anti-inflammatory and analgesic activity by reducing prostaglandin production. It is used in the research of musculoskeletal disorders.
    Butanixin
  • HY-105690
    SAR-115740 1253734-75-6 98%
    SAR-115740 is a TRPV1 antagonist. SAR-115740 exhibits developmental toxicity in H9 cell experiments. SAR-115740 can be used for research on inflammatory conditions or neurological disorders.
    SAR-115740
  • HY-105698
    Clofexamide 1223-36-5 98%
    Clofexamide (ANP 246; Amichlophene) is a potent antidepressant agent. Clofexamide also shows anti-inflammatory activity.
    Clofexamide
  • HY-105711
    RBx-7796 sodium 794528-96-4 98%
    RBx-7796 (sodium) is a competitive, highly selective, orally active 5-LO (IC50 = 3.5 mM for human 5-LO enzyme) inhibitor. RBx-7796 (sodium) can effectively inhibit 5-LO activity and LTB4 release. RBx-7796 (sodium) can significantly inhibit airway inflammation and bronchial constriction.
    RBx-7796 sodium
  • HY-105712
    CGP 57698 168082-74-4 98%
    CGP 57698 is an efficient CysLT receptor (Ki = 5.7 nM) antagonist. CGP 57698 can effectively counteract bronchoconstriction caused by LTD4. CGP 57698 can be used for research on asthma or allergic conditions.
    CGP 57698
  • HY-105825
    Sermetacin 57645-05-3 98%
    Sermetacin (SH-G 318AB) is an anti-inflammatory agent with biocompatibility and anti-inflammatory activity. Sermetacin is stable in saline and suitable for compound delivery. Sermetacin exhibits good biocompatibility in the RAW 264.7 mouse macrophage cell line. The anti-inflammatory response of sermetacin is comparable to that of its parent compound, indomethacin. Sermetacin may show potential in future applications of self-delivery of compound delivery.
    Sermetacin
  • HY-105852
    Proxazole 5696-09-3 98%
    Proxazole (Propoxaline) is an anti-inflammatory agent. Proxazole prevents Indomethacin (HY-14397)-induced ulcers without anti-secretory effect. Proxazole is also a spasmolytic papaverine-like agent.
    Proxazole
  • HY-105933
    L-652343 107008-29-7 98%
    L-652343 is a dual cyclooxygenase/lipoxygenase inhibitor. L-652343 can inhibit the production of LTB4 in isolated human polymorphonuclear leukocytes treated with Calcimycin (HY-N6687) (IC50: 1.4 μM), but it is inactive in whole blood. L-652343 can be used in the research of inflammatory and immune diseases.
    L-652343
  • HY-105977
    Chinoin 127 71392-29-5 98%
    Chinoin 127 is a non anesthetic analgesic agent with strong anti-inflammatory activity. Chinoin 127 shows better analgesic effect than acetylsalicylic acid (ASA) in the hot plate test, Randall Selitto test, and torsion test.
    Chinoin 127
  • HY-105991
    BMS-188184 161914-56-3 98%
    BMS-188184 is a type II s-PLA2 inhibitor (IC50 = 17 µM). BMS-188184 can be used for research on inflammatory conditions.
    BMS-188184
  • HY-106006
    RV-1729 1293915-42-0 98%
    RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-δ (PI3Kδ). RV-1729 identifies inhibition of the PI3K isotype by quantifying the release of phosphatidylinositol 3,4, 5-triphosphate (PIP3) (IC50=12 nM), showing twice the selectivity for PI3Kδ relative to PI3Kγ. RV-1729 is also 16 times more selective to PI3Kα. RV-1729 regulates immune and inflammatory responses by inhibiting PI3Kδ. RV-1729 can be used in studies of asthma and chronic obstructive pulmonary disease (COPD).
    RV-1729
Cat. No. Product Name / Synonyms Application Reactivity