2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P99056
    Utomilumab 1417318-27-4 99.90%
    Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to 4-1BB/CD137. Utomilumab can be used in the research of tumors such as follicular and other CD20+ non-Hodgkin lymphomas.
    Utomilumab
  • HY-N0029
    Forsythoside B 81525-13-5 99.99%
    Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
    Forsythoside B
  • HY-N0752
    Scutellarein 529-53-3
    Scutellarein is a natural flavonoid compound with anti-inflammatory effects.
    Scutellarein
  • HY-103171
    BAY 60-6583 910487-58-0 ≥99.0%
    BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50=3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model.
    BAY 60-6583
  • HY-134094
    Fluridone 59756-60-4 99.93%
    Fluridone is a herbicide, particularly to eliminate aquatic plant growth in water reservoirs and irrigation channels. Fluridone is a potent Abscisic acid (ABA) biosynthesis inhibitor, and has anti-inflammatory effects.
    Fluridone
  • HY-15556
    GSK269962A 850664-21-0
    GSK269962A (GSK 269962) is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively. GSK269962A has anti-inflammatory and vasodilatory activities.
    GSK269962A
  • HY-B1773A
    Sodium propionate 137-40-6 ≥99.0%
    Sodium Propionate is used as a food preservative, bakery product and as a mold inhibitor in insect cell cultures. It is also used as a preservative in pharmaceuticals, cosmetics, agriculture and animal feed. It is used as a food additive. In addition, it inhibits the growth of lactic acid bacteria.
    Sodium propionate
  • HY-12245
    SB-366791 472981-92-3 98.11%
    SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM). SB-366791 can be used for the research of inflammation.
    SB-366791
  • HY-14302
    Salmeterol 89365-50-4 99.70%
    Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.
    Salmeterol
  • HY-14842
    Givinostat 497833-27-9 98.67%
    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research.
    Givinostat
  • HY-B0008
    Sulindac 38194-50-2 99.68%
    Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and lung cancer.
    Sulindac
  • HY-117930
    Danicopan 1903768-17-1 99.91%
    Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
    Danicopan
  • HY-130246
    NF-56-EJ40 2380230-73-7 99.92%
    NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.
    NF-56-EJ40
  • HY-N2364
    Arecoline 63-75-2 99.84%
    Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress.
    Arecoline
  • HY-144998
    NVP-DKY709 2291360-73-9 98.86%
    NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2.
    NVP-DKY709
  • HY-N0575
    Pinocembrin 480-39-7 99.67%
    Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties.
    Pinocembrin
  • HY-N0741
    Leonurine 24697-74-3 99.86%
    Leonurine is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.
    Leonurine
  • HY-P2136
    COG1410 878009-24-6 98.85%
    COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease.
    COG1410
  • HY-P9918
    Tremelimumab 745013-59-6 99.50%
    Tremelimumab (Ticilimumab) is a fully human monoclonal antibody specific for cytotoxic T-lymphocyte antigen-4 (CTLA-4) and can be used for metastatic melanoma research.
    Tremelimumab
  • HY-10328
    Neflamapimod 209410-46-8 ≥98.0%
    Neflamapimod (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM. Neflamapimod (VX-745) possesses anti-inflammatory activity.
    Neflamapimod
Cat. No. Product Name / Synonyms Application Reactivity