2. Infection

Infection

Infection

Related Products

PDF 70.44 MB

Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-163666
    HIV-1 inhibitor-68 98%
    HIV-1 inhibitor-68 (compound 26) is a protein kinase C (PKC) activator derivative with reversal activity in HIV-1 latency. HIV-1 inhibitor-68 may be able to eliminate cells latently infected with HIV-1,.
    HIV-1 inhibitor-68
  • HY-163693
    Antifungal agent 104 98%
    Antifungal agent 104 (Compound 5e) exhibits antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani and Botrytis cinerea, with EC50 of 1.52 μg/mL, 0.06 μg/mL and 15.69 μg/mL, respectively. Antifungal agent 104 exhibits low cytotoxicity to human renal cell 239A (6.28-100 mM).
    Antifungal agent 104
  • HY-163713
    SARS-CoV-2-IN-89 1016762-41-6 98%
    SARS-CoV-2-IN-89 (Compound 2) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-89 enhances IFN-I responses to SARS-CoV-2 infection in A549.hACE2 cells.
    SARS-CoV-2-IN-89
  • HY-163716
    Antibacterial agent 222 98%
    Antibacterial agent 222 ((R)-O30 (5)) is a antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).
    Antibacterial agent 222
  • HY-163727
    MMV1557817 2065197-82-0 98%
    MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites.
    MMV1557817
  • HY-163734
    Tyrosinase-IN-30 98%
    Tyrosinase-IN-30 (compound 11c) is a potent tyrosinase inhibitor with an IC50 value of 4.52 µM. Tyrosinase-IN-30 shows anti-bacterial activity.
    Tyrosinase-IN-30
  • HY-163738
    Furin-IN-2 98%
    Furin-IN-2 (compound P3) is a potent inhibitor of furin, with the IC50 of 35 μM. Furin-IN-2 shows antiviral activity.
    Furin-IN-2
  • HY-163742
    SARS-CoV-2 Mpro-IN-22 1236310-35-2 98%
    SARS-CoV-2 Mpro-IN-22 (compound 4), a hydrolysable tannin, is a potent SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 value of 1.2 µg/mL. SARS-CoV-2 Mpro-IN-22 does not show any significant cytotoxic activity against A549 and HUVEC cell lines.
    SARS-CoV-2 Mpro-IN-22
  • HY-163754
    TMV-IN-9 412315-55-0 98%
    TMV-IN-9 (compound A6) is an antiviral agent that displays excellent inactivating against tobacco mosaic virus (TMV) with an EC50 of 62.8 μg/mL. TMV-IN-9 shows strong binding capacity to TMV coat protein with a binding affinity value of 1.862 μM. TMV-IN-9 obviously destroys the integrity of the TMV particles and blocked the virus from infecting the host.
    TMV-IN-9
  • HY-163773
    JNJ-7950 99.88%
    JNJ-7950 (compound 5c) exhibits antiviral activity against RSV with an EC50 value of 0.78 nM. JNJ-7950 can be used in the study of respiratory tract infections.
    JNJ-7950
  • HY-163780
    AChE-IN-66 98%
    Nematicidal agent 1 is a potent nematicidal agent. Nematicidal agent 1 binds to the pocket of acetylcholine esterase (AChE).
    AChE-IN-66
  • HY-163781
    Antifungal agent 105 3038220-10-6 98%
    Antifungal agent 105 (compound A25) is a potent antifungal agent. Antifungal agent 105 shows protective and curative effects .
    Antifungal agent 105
  • HY-163783
    CSNK2-IN-1 98%
    CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development.
    CSNK2-IN-1
  • HY-163833
    MMV1634566 98%
    MMV1634566 is a potent antimalarial agent. MMV1634566 inhibits Plasmodium falciparum. MMV1634566 shows cytotoxicity.
    MMV1634566
  • HY-163838
    Quorum sensing-IN-6 98%
    Quorum sensing-IN-6 (compound 27) is a quorum sensing (QS) inhibitor with IC50 values of 8 and 106 nM for E.coli and Pyocyanin, respectively.
    Quorum sensing-IN-6
  • HY-163843
    Antibacterial agent 234 98%
    Antibacterial agent 234 (6p) is an antibacterial agent. Antibacterial agent 234 (6p) exhibits good activity against Klebsiella pneumoniae with a MIC value of 6.25 µg/mL.
    Antibacterial agent 234
  • HY-163887
    PBZ1038 2043687-46-1 98%
    PBZ1038 is a highly effective inhibitor of Gram-negative chaperone proteins, achieving its antibacterial effect by inhibiting GroES/GroEL.
    PBZ1038
  • HY-163891
    Antifungal agent 107 2684411-12-7 98%
    Antifungal agent 107 (compound b24) is an OSBP inhibitor with antifungal activity. Antifungal agent 107 can be used to control cucumber downy mildew and potato late blight in greenhouse.
    Antifungal agent 107
  • HY-163913
    SARS-CoV-IN-5 98%
    SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CLpro inhibitor with IC50s of 38 nM, 21.1 nM and 86 nM for 3CLpro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC50 of 0.272 μM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9.
    SARS-CoV-IN-5
  • HY-163999
    TMV-IN-12 2861919-00-6 98%
    TMV-IN-12 (compound 4) is an inhibitor of tobacco mosaic virus (TMV) with antifungal properties. TMV-IN-12 effectively prevents TMV particle aggregation and self-assembly of TMV capsid protein (TMV-CP) (Kd=0.142 μM), preventing TMV from infecting tobacco plants.
    TMV-IN-12
Cat. No. Product Name / Synonyms Application Reactivity