2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-158687
    SARS-CoV-2 Mpro-IN-18 98%
    SARS-CoV-2 Mpro-IN-18 (compound 84) is a potent SARS-CoV-2 Mpro inhibitor with the IC50 of 3.23 nM. SARS-CoV-2 Mpro-IN-18 can be used for study of anti-SARS-CoV-2 agent.
    SARS-CoV-2 Mpro-IN-18
  • HY-158690
    DDD00057570 338965-07-4 98%
    DDD00057570 is a selective M17 leucyl-aminopeptidase (LAP) inhibitor. DDD00057570 inhibits L. major and L. donovani intracellular amastigotes in vitro growth.
    DDD00057570
  • HY-158700
    DprE1-IN-10 1254782-81-4 98%
    DprE1-IN-10 (hit 2) is a Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1) inhibitor. DprE1-IN-10 can be used for tuberculosis research.
    DprE1-IN-10
  • HY-158751
    Jun9-72-2 2657659-42-0 98%
    Jun9-72-2 is a papain (Plpro) inhibitor of SARS-CoV-2 with an IC50 value of 0.67 μM. Jun9-72-2 has antiviral activity.
    Jun9-72-2
  • HY-158761
    Polyaminopropyl biguanide 133029-32-0 98%
    Polyaminopropyl biguanide (PAPB), a propyl analogue of polyhexamethylene biguanide, is a broad spectrum, fast acting bactericide with antibacterial activity. Polyaminopropyl biguanide can be used as a preservative in cosmetic products.
    Polyaminopropyl biguanide
  • HY-158763
    MPI8 856242-63-2 98%
    MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). This dual inhibition enhanced the overall antiviral potency and effect of MPI8. MPI8 can be used in clinical studies of COVID-19.
    MPI8
  • HY-158815
    SM-102 N-Oxide 2824195-50-6 98%
    SM-102 N-oxide (Lipid H N-Oxide) is an impurity of SM-102 (HY-134541).
    SM-102 N-Oxide
  • HY-158818
    DXR-IN-2 2260608-07-7 98%
    DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR.
    DXR-IN-2
  • HY-158867
    DOSPA (hydrochlorid) 913194-16-8 98%
    DOSPA hydrochlorid is a frequently utilized cationic lipid in the generation of Lipid Nanoparticles (LNPs) for the development of mRNA vaccines, including the COVID-19 vaccine.
    DOSPA (hydrochlorid)
  • HY-158905
    MTDB-Alkyne 2923694-73-7 98%
    MTDB-Alkyne is an alkyne-containing click chemistry reagent. MTDB-Alkyne can be used to synthesize Proximity-Induced Nucleic Acid Degrader (PINAD) for the degradation of SARS-CoV-2 RNA.
    MTDB-Alkyne
  • HY-158935
    Dihydro K22 2926907-58-4 98%
    Dihydro K22 is a derivative of the antiviral agent K22 (HY-122668).
    Dihydro K22
  • HY-158977
    β-Lactamase-IN-9 98%
    β-Lactamase-IN-9 (compound 2) is a β-lactamase inhibitor that can restore the sensitivity of pathogens to β-lactam antibiotics.
    β-Lactamase-IN-9
  • HY-158980
    Antifungal agent 103 98%
    Antifungal agent 103 (compound 7y) is a potent antifungal agent. Antifungal agent 103 inhibits R. solani with an EC50 of 0.47 μg/mL.
    Antifungal agent 103
  • HY-159103
    LeuRS-IN-2 98%
    LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota.
    LeuRS-IN-2
  • HY-159118
    PC-Qz1 98%
    PC-Qz1 is a mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor with an IC50 of 470 nM. PC-Qz1 has antibacterial activity.
    PC-Qz1
  • HY-159477
    SARS-CoV-2-IN-92 2123489-12-1 98%
    SARS-CoV-2-IN-92 (compound 11) inhibits SARS-CoV-2 variants (EC50 = 0.48 μM), as well as SARS-CoV and MERS-CoV. SARS-CoV-2-IN-92 (compound 11) potently and selectively blocks ERα-Glu II.
    SARS-CoV-2-IN-92
  • HY-159603
    S-WJM992 98%
    S-WJM992 (compound 10ahb) is an antiparasitic agent that inhibits ATPase activity under high [Na+] conditions. S-WJM992 also has significant inhibitory effects on parasites that have developed PfATP4 inhibitor-resistance. S-WJM992 is a potential transmission blocker that effectively inhibits gamete development and prevents parasite transmission to mosquitoes via blood feeding.
    S-WJM992
  • HY-159640
    NVP-FVP954 98%
    NVP-FVP954 is a fast-acting antimalarial agent with potential for severe malaria. FVP954 has a high barrier to resistance, long half-life, and high solubility, making it suitable for intravenous administration.
    NVP-FVP954
  • HY-159666
    Nystatin A1 34786-70-4 98%
    Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi.
    Nystatin A1
  • HY-159687
    Nafithromycin 1691240-78-4 98%
    Nafithromycin (WCK 4873) is an orally available antibiotic that inhibits community-acquired pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Methicillin (HY-121544)-susceptible Staphylococcus aureus. The MIC90 of nafithromycin against macrolide-resistant and telithromycin (HY-A0062)-insensitive Streptococcus pneumoniae is 0.12 mg/liter.
    Nafithromycin
Cat. No. Product Name / Synonyms Application Reactivity