2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-157322
    SAV13 423748-49-6 98%
    SAV13 is an inhibitor of SaeR. SAV13 is an analogue of HR3744. SAV13 inhibits SaeR-DNA probe binding and has antivirulence properties.
    SAV13
  • HY-157333
    CYP51-IN-15 3034186-60-9 98%
    CYP51-IN-15 (9B) is a BBB penetrated Naegleria fowleri-specific CYP51 inhibitor, with an EC50 of 1.5 μM.
    CYP51-IN-15
  • HY-157405
    DENV-IN-11 98%
    DENV-IN-11 (SC27), a sulfonamide chalcone, is a potent DENV inhibitor that targeted viral methyltransferase. DENV-IN-11 reduced DENV2 replicon replication. DENV-IN-11 can be used for dengue infection research.
    DENV-IN-11
  • HY-157431
    Mycobacterium Tuberculosis-IN-2 2284580-65-8 98%
    Mycobacterium Tuberculosis-IN-2 (Compound 29) is a bacterial inhibitor that effectively inhibits Mycobacterium Tuberculosis. Mycobacterium Tuberculosis-IN-2 can be used in tuberculosis research (MIC = 0.07-0.16 μM).
    Mycobacterium Tuberculosis-IN-2
  • HY-157439
    SARS-CoV-2-IN-72 98%
    SARS-CoV-2-IN-72 (compound 12) is a potent allosteric inhibitor of the SARS-COV-2 papain-like protease domain that can trigger the degradation of NSP3.
    SARS-CoV-2-IN-72
  • HY-157446
    MoTPS1/2-IN-1 98%
    MoTPS1/2-IN-1 (Compound A1-4 ) is a bispecific inhibitor of MoTps1 and MoTps2. MoTPS1/2-IN-1 has antifungal activity and showed good inhibitory activity against the growth and virulence of B. cinerea and F. graminearum.
    MoTPS1/2-IN-1
  • HY-157454
    Antiviral agent 48 3032868-59-7 98%
    Antiviral agent 48 (compound 9m) is a pan-antiviral agent. Antiviral agent 48 has anti-HEV activity and cytotoxicity (EC90=30.6 nM; CC50=13.8 nM).
    Antiviral agent 48
  • HY-157459
    SDH-IN-11 2998946-58-8 98%
    SDH-IN-11 (compound A7) is a SDH inhibitor, and shows inhibitory effect on nematode feeding, reproductive ability, and egg hatching. SDH-IN-11 promotes the oxidative stress of nematodes and causes intestinal damage to nematodes. SDH-IN-11 inhibits the activity of succinate dehydrogenase (SDH) in nematodes.
    SDH-IN-11
  • HY-157462
    FC14-584B 1358567-64-2 98%
    FC14-584B, a dithiocarbamate, is a β-Carbonic Anhydrase inhibitor. FC14-584B inhibits the growth of trophozoites. FC14-584B can be used for the research of tuberculosis.
    FC14-584B
  • HY-157466
    Antiparasitic agent-21 98%
    Antiparasitic agent-21 (compound 28) has selectively antiparasitic activity against Naegleria fowleri with an EC50 of 0.92 μM. Antiparasitic agent-21 has excellent blood-brain barrier permeability.
    Antiparasitic agent-21
  • HY-157539
    PB49673382 2763495-65-2 98%
    PB49673382 is a SARS-CoV-2 inhibitor. PB49673382 inhibits virus replication and consequent cytopathic effects of the virus with an IC50 of 6.42 μM.
    PB49673382
  • HY-157794
    6-Nitroquinazoline 7556-95-8 98%
    6-Nitroquinazoline is an antimalarial agent. 6-Nitroquinazoline is also a substrate for human liver aldehyde oxidase.
    6-Nitroquinazoline
  • HY-157805
    PROTAC SARS-CoV-2 Mpro degrader-2 98%
    PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 Mpro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC50 of 0.89 μM.
    PROTAC SARS-CoV-2 Mpro degrader-2
  • HY-157848
    SARS-CoV-2-IN-82 924058-34-4 98%
    SARS-CoV-2-IN-82 (compound A) is a Programmed-1 ribosomal frameshift (-1 PRF) inhibitor of SARS-CoV-2.
    SARS-CoV-2-IN-82
  • HY-15789R
    Elbasvir (Standard) 1370468-36-2
    Elbasvir (Standard) is the analytical standard of Elbasvir. This product is intended for research and analytical applications. Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.
    Elbasvir (Standard)
  • HY-158193
    N-Decanoyl cyclopentylamide 540796-75-6 98%
    N-Decanoyl cyclopentylamide (C10-CPA) is a potent inhibitor of quorum sensing in Pseudomonas aeruginosa. N-Decanoyl cyclopentylamide interferes with expression of Pseudomonas aeruginosa virulence factors regulated by the las and rhl quorum-sensing systems. N-Decanoyl cyclopentylamide inhibits production of elastase, pyocyanin, and rhamnolipid and biofilm formation.
    N-Decanoyl cyclopentylamide
  • HY-158364
    NMT-IN-3 3061506-36-0 98%
    NMT-IN-3 is an inhibitor of N-myristoyltransferase (NMT). The IC50 of NMT-IN-3 for Plasmodium vivax NMT is 38 mM.
    NMT-IN-3
  • HY-158419
    PB(OH)3 1854111-80-0 98%
    PB(OH)3 is an anti-HIV-1 agent that can be used in antiviral research.
    PB(OH)3
  • HY-158570
    (2E)-Eicosenoic acid 2127095-72-9 98%
    (2E)-Eicosenoic acid is an inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA). (2E)-Eicosenoic acid exhibits strong inhibitory activity against PtpA with an IC50 value in the low micromolar range. (2E)-Eicosenoic acid can be used for research on Mycobacterium tuberculosis infection.
    (2E)-Eicosenoic acid
  • HY-158682
    LpxC-IN-13 3033881-14-7 98%
    LpxC-IN-13 (Compound 13) is a LpxC inhibitor, with an IC50 18.06 nM. LpxC-IN-13 effectively inhibits Gram-negative bacterial infection.
    LpxC-IN-13
Cat. No. Product Name / Synonyms Application Reactivity