2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14879R
    Avibactam free acid (Standard) 1192500-31-4
    Avibactam (free acid) (Standard) is the analytical standard of Avibactam (free acid). This product is intended for research and analytical applications. Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].
    Avibactam free acid (Standard)
  • HY-14881R
    Bedaquiline (Standard) 843663-66-1
    Bedaquiline (Standard) is the analytical standard of Bedaquiline. This product is intended for research and analytical applications. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis.
    Bedaquiline (Standard)
  • HY-148831
    Antibacterial agent 135 2233569-54-3 98%
    Antibacterial agent 135 (example 7) is a potent antibacterial agent. Antibacterial agent 135 can inhibit P. aeruginosa, A. baumannii, E. coli, and K. pneumoniae, with MIC>64 μg/mL.
    Antibacterial agent 135
  • HY-14904R
    Umifenovir (Standard) 131707-25-0
    Umifenovir (Standard) is the analytical standard of Umifenovir. This product is intended for research and analytical applications. Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro. Umifenovir shows anti-inflammatory activity.
    Umifenovir (Standard)
  • HY-149155
    o-Cymen-5-ol 39660-61-2 98%
    o-Cymen-5-ol is a broad-spectrum antimicrobial agent with direct antimicrobial activity. o-Cymen-5-ol showed effective minimum inhibitory concentrations (MICs) against a variety of bacteria and fungi, such as Streptococcus mutans and Candida albicans. The combination of o-Cymen-5-ol and zinc showed synergistic effects, enhancing the inhibitory effect against oral pathogens. o-Cymen-5-ol was able to inhibit the glycolysis process and co-enhanced this effect with zinc. o-Cymen-5-ol showed a stronger antibacterial effect in toothpaste than placebo.
    o-Cymen-5-ol
  • HY-149450
    Aflastatin A 179729-59-0 98%
    Aflastatin A, a microbial metabolite, is an aflatoxin production inhibitor. Aflastatin A inhibits production of both aflatoxin B and G groups.
    Aflastatin A
  • HY-14957R
    Ozenoxacin (Standard) 245765-41-7
    Ozenoxacin (Standard) is the analytical standard of Ozenoxacin. This product is intended for research and analytical applications. Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.
    Ozenoxacin (Standard)
  • HY-149649
    SARS-CoV-2-IN-64 98%
    SARS-CoV-2-IN-64 (compound 9), a chenodeoxycholic acid derivative, is a potent inhibitor of spike glycoprotein of SARS-CoV-2.
    SARS-CoV-2-IN-64
  • HY-149699
    DHFR-IN-12 98%
    DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity.
    DHFR-IN-12
  • HY-149722
    Antiparasitic agent-20 98%
    Antiparasitic agent-20 (Compound 1p) is a parasite inhibitor with broad antiparasitic activity. Antiparasitic agent-20 has inhibitory effects on T. brucei and T. cruzi with EC50 values of 0.09 μM and 14.1 μM respectively.
    Antiparasitic agent-20
  • HY-149775
    Urease-IN-10 1012205-70-7 98%
    Urease-IN-10 (Conjugate 4) is a competitive Urease inhibitor, with an IC50 of 3.59±0.07 μM and a Ki of 7.45 μM. Urease-IN-10 is a conjugate consisting of Diclofenac (HY-15036) and Sulfanilamide (HY-B0242). Diclofenac-sulfanilamide inhibits the Jack bean urease(JBU) in a competitive manner.
    Urease-IN-10
  • HY-149778
    Antifungal agent 87 692730-21-5 98%
    Antifungal agent 87(10) acts as a highly potent PDT antimycotic photosensitizer (PDT-IC50 = 1 nM for T. rubrum).
    Antifungal agent 87
  • HY-149799
    28-O-Imidazolyl-azepano-betulin 98%
    SARS-CoV-2-IN-70 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC50 of 3.2 μM.
    28-O-Imidazolyl-azepano-betulin
  • HY-15005R
    Sofosbuvir (Standard) 1190307-88-0
    Sofosbuvir (Standard) is the analytical standard of Sofosbuvir. This product is intended for research and analytical applications. Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM.
    Sofosbuvir (Standard)
  • HY-150306
    IM-250 2305750-23-4 99.94%
    IM-250 is an orally active helicase-primase inhibitor. IM-250 is effective against HSV infection. IM-250 inhibits HSV-1 infection in Vero cells (IC50: ~20 nM).
    IM-250
  • HY-150756
    EBOV-GP-IN-1 3032283-85-2 98%
    EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC50 of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).
    EBOV-GP-IN-1
  • HY-151150
    Trypanothione synthetase-IN-2 3033799-60-6 98%
    Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 5.4 μM when triamine spermidine is as polyamine S.
    Trypanothione synthetase-IN-2
  • HY-151165
    LasR-IN-3 2810894-92-7 99.57%
    LasR-IN-3 is a LasR inhibitor against Pseudomonas aeruginosa. LasR-IN-3 induces LasR structure instability and completely dissociates LasR functioning dimeric form.
    LasR-IN-3
  • HY-15136R
    Lonafarnib (Standard) 193275-84-2
    Lonafarnib (Standard) is the analytical standard of Lonafarnib. This product is intended for research and analytical applications. Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.
    Lonafarnib (Standard)
  • HY-151418
    Chitin synthase inhibitor 8 98%
    Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection.
    Chitin synthase inhibitor 8
Cat. No. Product Name / Synonyms Application Reactivity