2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-150514
    ARN1468 1381459-14-8 99.34%
    ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM.
    ARN1468
  • HY-150784
    XR8-89 2817811-16-6
    XR8-89 is a potent papain-like protease (PLpro) inhibitor with an IC50 value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research.
    XR8-89
  • HY-151482
    SARS-CoV-2 Mpro-IN-2 2768834-39-3 98.96%
    SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies.
    SARS-CoV-2 Mpro-IN-2
  • HY-151561
    WM382 2606990-92-3 99.35%
    WM382 is an orally active and potent dual plasmepsin IX/X (PMIX/X) inhibitor with IC50 values of 1.4 nM and 0.03 nM, respectively. WM382 has robust in vivo efficacy at multiple stages of the malaria parasite life cycle and an excellent resistance profile.
    WM382
  • HY-153083
    COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
    COVID-19 Spike Protein mRNA will express COVID-19 spike protein, and suitable for detection of RNA delivery, translation efficiency, cell viability, etc. COVID-19 spike protein is the novel coronavirus pneumonia spike protein located on the membrane surface. COVID-19 spike protein undertakes the functions of virus binding to host cell membrane receptors and membrane fusion, thereby mediating the entry of COVID-19 virus into cells. COVID-19 spike protein is an important site of action for host neutralizing antibodies and a key target for vaccine design.
    COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
  • HY-158128
    MK-8527 1810869-23-8 99.02%
    MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012).
    MK-8527
  • HY-159700
    AA3-DLin 3027565-91-6 ≥99.0%
    AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model.
    AA3-DLin
  • HY-162066
    DNDI-6174 2868298-43-3
    DNDI-6174 is a cytochrome bc1 complex inhibitor with potent in vitro activity against a variety of Leishmania species. DNDI-6174 can reduce parasite burden in animal models of infection.
    DNDI-6174
  • HY-16581A
    DL-threo-2-methylisocitrate sodium
    DL-threo-2-methylisocitrate sodium salt is a substrate of isocitrate lyase 1 (ICL1).
    DL-threo-2-methylisocitrate sodium
  • HY-16955A
    Plazomicin sulfate 1380078-95-4 ≥98.0%
    Plazomicin (ACHN 490) sulfate is a potent aminoglycoside antibiotic in the fight against antimicrobial resistance. Plazomicin sulfate is against several multi-drug-resistant organisms, including carbapenem-resistant Enterobacteriaceae. Plazomicin sulfate has the potential to be used for multi-drug-resistant complicated urinary tract infections (cUTIs) or in combination for serious carbapenem-resistant Enterobacteriaceae infections.
    Plazomicin sulfate
  • HY-17450A
    Aplaviroc hydrochloride 461023-63-2 99.94%
    Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
    Aplaviroc hydrochloride
  • HY-19285A
    Sulfaclozine sodium 23307-72-4 99.02%
    Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
    Sulfaclozine sodium
  • HY-A0181S
    Adenosine monophosphate-13C10,15N5 dilithium ≥99.0%
    Adenosine monophosphate-13C10,15N5(AMP-13C10,15N5) is the 13C-labeled and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-13C10,15N5 dilithium
  • HY-A0248B
    Polymyxin B2 34503-87-2
    Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains.
    Polymyxin B2
  • HY-B0117S
    Tigecycline-d9 2699607-86-6
    Tigecycline-d9 is deuterium labeled Tigecycline. Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively.
    Tigecycline-d9
  • HY-B0220D
    Erythromycin thiocyanate 7704-67-8
    Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].
    Erythromycin thiocyanate
  • HY-B1149A
    Bacampicillin hydrochloride 37661-08-8 99.94%
    Bacampicillin hydrochloride is a penicillin antibiotic, is a prodrug of ampicillin with improved oral bioavailability.
    Bacampicillin hydrochloride
  • HY-B1620H
    Polyvinylpyrrolidone K90 9003-39-8 ≥98.0%
    Polyvinylpyrrolidone K90 can be used to prepare drug delivery systems, such as electrospun nanofibrous membranes. Polyvinylpyrrolidone K90 is widely used in human and veterinary medicine as an effective wound healing promoter and disinfectant when combined with iodine and other compounds. In addition, Polyvinylpyrrolidone K90 is also used to stabilize nanosuspensions, interact with the surface of drug crystals, and remain bound to the surface after drying.
    Polyvinylpyrrolidone K90
  • HY-B1743S
    Puromycin-d3 98.96%
    Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
    Puromycin-d3
  • HY-B2080A
    Etidocaine hydrochloride 36637-19-1 ≥98.0%
    Etidocaine (hydrochloride) is a long aminoamide local agent that can suppress or relieve pain.
    Etidocaine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity