2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126396
    Sordarin sodium 463356-00-5 ≥99.0%
    Sordarin sodium is an eEF2 inhibitor and antibiotic. Sordarin sodium's function is dependent on the diphthamide modification on eEF2. Sordarin sodium inhibits protein synthesis by preventing the binding of eEF2 to the ribosome complex. Sordarin sodium has antifungal activity.
    Sordarin sodium
  • HY-12653A
    LDC4297 hydrochloride 2319747-14-1 98.23%
    LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection.
    LDC4297 hydrochloride
  • HY-128467
    Dehydroacetic acid sodium 4418-26-2 99.87%
    Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.
    Dehydroacetic acid sodium
  • HY-130703
    5-Dehydroepisterol 23582-83-4
    5-Dehydroepisterol is an episterol derivative and an intermediate in steroid biosynthesis. 5-Dehydroepisterol can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase. 5-Dehydroepisterol has anti-fungal activities.
    5-Dehydroepisterol
  • HY-133154
    Carboxyaminoimidazole ribotide 6001-14-5 98.31%
    Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine.
    Carboxyaminoimidazole ribotide
  • HY-135659
    BSH-IN-1 2553217-91-5 99.82%
    BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.
    BSH-IN-1
  • HY-135761
    Penconazole 66246-88-6 98.91%
    Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole
  • HY-136450
    Triclabendazole sulfoxide 100648-13-3 98.78%
    Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP.
    Triclabendazole sulfoxide
  • HY-136466
    A2ti-2 482646-13-9 99.27%
    A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection.
    A2ti-2
  • HY-13735B
    Quinacrine hydrochloride hydrate 6151-30-0 98.18%
    Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis.
    Quinacrine hydrochloride hydrate
  • HY-13735D
    d-Atabrine dihydrochloride 56100-41-5 99.64%
    d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity.
    d-Atabrine dihydrochloride
  • HY-13771R
    Ursodeoxycholic acid (Standard) 128-13-2 99.83%
    Ursodeoxycholic acid (Standard) is the analytical standard of Ursodeoxycholic acid. This product is intended for research and analytical applications. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active.
    Ursodeoxycholic acid (Standard)
  • HY-138597
    5'-O-TBDMS-dT 40733-28-6 ≥98.0%
    5'-O-TBDMS-dT is a nucleoside with protective and modification effects.
    5'-O-TBDMS-dT
  • HY-138610
    5'-O-DMT-Bz-rC 81246-76-6 99.69%
    5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-Bz-rC
  • HY-143899
    FBA-IN-1 2605897-57-0 98.79%
    FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL.
    FBA-IN-1
  • HY-144513
    Stigmastan-3β-ol 19466-47-8 99.70%
    Stigmastan-3β-ol is a sterol that can be isolated from Tinospora sinensis and Ginkgo biloba L.. Stigmastan-3β-ol has antimicrobial activity.
    Stigmastan-3β-ol
  • HY-14743B
    Golotimod hydrochloride 1029401-59-9 99.79%
    Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).
    Golotimod hydrochloride
  • HY-149048
    Adenosylhomocysteinase 9025-54-1
    Adenosylhomocysteinase (SAHH; AHCY) is a highly conserved enzyme. Adenosylhomocysteinase reversible catalyzes S-adenosylhomocysteine (SAH) to adenosine and L-homocysteine. The serum exosomal Adenosylhomocysteinase level can be used as a prognostic biomarker in HBV-LC patients.
    Adenosylhomocysteinase
  • HY-152117
    Acetyl-CoA Carboxylase-IN-1 179343-23-8 99.18%
    Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity.
    Acetyl-CoA Carboxylase-IN-1
  • HY-155635
    Nav1.8-IN-4 1620846-16-3 99.78%
    Nav1.8-IN-4 (compound 9a) is a Nav1.8 channel inhibitor (IC50=0.014 μM). Nav1.8-IN-4 can be used for research on pain-related diseases.
    Nav1.8-IN-4
Cat. No. Product Name / Synonyms Application Reactivity