2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00125
    CGP-53153 149281-19-6 98%
    CGP-53153 is a steroidal inhibitor of 5 alpha reductase with IC50s of 36 and 262 nM in rat and human prostatic tissue, respectively.
    CGP-53153
  • HY-U00298
    Amebucort 83625-35-8 99.0%
    Amebucort is a synthetic glucocorticoid corticosteroid, may used for the research of inflammatory disorders.
    Amebucort
  • HY-107795R
    Benorilate (Standard) 5003-48-5 99.85%
    Benorilate (Standard) is the analytical standard of Benorilate. This product is intended for research and analytical applications. Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorylate has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis.
    Benorilate (Standard)
  • HY-114464S
    11-Beta-hydroxyandrostenedione-d4 2687960-98-9 98.3%
    11-Beta-hydroxyandrostenedione-d4 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor.
    11-Beta-hydroxyandrostenedione-d4
  • HY-14301AR
    Olodaterol hydrochloride (Standard) 869477-96-3 99.36%
    Olodaterol (hydrochloride) (Standard) is the analytical standard of Olodaterol (hydrochloride). This product is intended for research and analytical applications. Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.
    Olodaterol hydrochloride (Standard)
  • HY-146627S
    5-Cholesten-24(RS)-methyl-3β-ol-d3 99.21%
    5-Cholesten-24(RS)-methyl-3β-ol-d3 is the deuterium labeled 5-Cholesten-24(RS)-methyl-3β-ol.
    5-Cholesten-24(RS)-methyl-3β-ol-d3
  • HY-17495AR
    Carteolol hydrochloride (Standard) 51781-21-6 99.58%
    Carteolol hydrochloride (Standard) is the analytical standard of Carteolol hydrochloride. This product is intended for research and analytical applications. Carteolol hydrochloride (OPC-1085 hydrochloride) is a non-selective beta blocker used to treat glaucoma.
    Carteolol hydrochloride (Standard)
  • HY-B0354AR
    Urapidil hydrochloride (Standard) 64887-14-5 99.98%
    Urapidil (hydrochloride) (Standard) is the analytical standard of Urapidil (hydrochloride). This product is intended for research and analytical applications. Urapidil hydrochloride is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect.
    Urapidil hydrochloride (Standard)
  • HY-W008581
    Estradiol 3-methyl ether 1035-77-4 99.93%
    Estradiol 3-methyl ether is a synthetic estrogen. Estradiol 3-methyl ether can disrupt microtubule networks in V79 cells with an EC50 of 9 μM, as well as inhibiting cell proliferation. Estradiol 3-methyl ether decreases the serum cholesterol levels and increases body weight loss, which indicates feminizing activity in HFD murine model.
    Estradiol 3-methyl ether
  • HY-W009066
    2-Ethylhexyl diphenyl phosphate 1241-94-7
    2-Ethylhexyl diphenyl phosphate is an organophosphate flame retardants (OPFRs) and a PPARG agonist (EC20: 2.04 µM). 2-Ethylhexyl diphenyl phosphate also inhibits ERRγ transcriptional activity (IC50: 1.3 µM). 2-Ethylhexyl diphenyl phosphate upregulates 3β-HSD1, human chorionic gonadotropin (hCG) and progesterone secretion. 2-Ethylhexyl diphenyl phosphate can be used in studies of female reproduction and fetal development.
    2-Ethylhexyl diphenyl phosphate
  • HY-W060074
    1-Acetyl-β-carboline 50892-83-6
    1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin.
    1-Acetyl-β-carboline
  • HY-W336192
    (3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate 163041-94-9
    (3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate is a sex pheromone capable of attracting male South American tomato pinworms (Scrobipalpuloides absoluta), which can be isolated from the tomato pest.
    (3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate
  • HY-W749143
    Bombykal 63024-98-6 98%
    Bombykal is a female pheromone isolated from the abdominal components of Bombys mori L.
    Bombykal
  • HY-W780803
    (Z,E)-9,12-Tetradecadienol 42521-46-0
    (Z,E)-9,12-Tetradecadienol is a synthetic enhancer of male Ephestia cautella attraction.
    (Z,E)-9,12-Tetradecadienol
  • HY-W011055A
    6-Hydroxycortisol 3078-34-0 98%
    6-Hydroxycortisol is the metabolite of Cortisol (HY-N0583). 6-Hydroxycortisol can be used as an indicator of Cortisol metabolism.
    6-Hydroxycortisol
  • HY-W014684R
    Lilial (Standard) 80-54-6
    Lilial (Standard) is the analytical standard of Lilial. This product is intended for research and analytical applications. Lilial is a widely used synthetic fragrance and ester in consumer products. Lilial possesses estrogenic activity in vitro. Lilial can induce a toxic effect on mitochondria that causes a decrease in the viability of HaCaT cells. Lilial can increase NRF2 protein level in vitro. Lilial is able to target respiratory chain complexes, inhibit complexes I and II of the electron transport chain, increase the generation of reactive oxygen species, and decrease the level of intracellular ATP. Lilial can induce systemic toxicity in vivo. Lilial induces significant DNA strand breaks.
    Lilial (Standard)
  • HY-W014901S
    Bisphenol F-13C6 1410794-06-7 98.32%
    Bisphenol F-13C6 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).
    Bisphenol F-13C6
  • HY-15371G
    Forskolin (GMP) 66575-29-9 98%
    Forskolin (Coleonol) (GMP) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin (GMP) is also an inducer of intracellular cAMP formation. Forskolin (GMP) induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin (GMP) exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin (GMP) also induces autophagy.
    Forskolin (GMP)
  • HY-B0813R
    Treprostinil diethanolamine (Standard) 830354-48-8
    Geniposide (Standard) is the analytical standard of Geniposide. This product is intended for research and analytical applications. Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
    Treprostinil diethanolamine (Standard)
  • HY-101735R
    (9Z,11E)-Prodlure (Standard) 50767-79-8
    (9Z,11E)-Prodlure (Standard) is the analytical standard of (9Z,11E)-Prodlure. This product is intended for research and analytical applications. (9Z,11E)-Prodlure ((9Z,11E)-Tetradecadien-1-yl acetate) is the main component of the sex pheromone of female Spodoptera littoralis[1].
    (9Z,11E)-Prodlure (Standard)
Cat. No. Product Name / Synonyms Application Reactivity