2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P0262
    Galantide 138579-66-5 98%
    Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM).
    Galantide
  • HY-P0298
    [Des-Arg9]-Bradykinin 15958-92-6 98%
    [Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors.
    [Des-Arg9]-Bradykinin
  • HY-P1179
    Guanylin(human) 183200-12-6 98%
    Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.
    Guanylin(human)
  • HY-P1235
    Carperitide 89213-87-6 98%
    Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.
    Carperitide
  • HY-P1393
    AC 187 151804-77-2 98.86%
    AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects.
    AC 187
  • HY-P1463
    Calcitonin, eel 57014-02-5 98%
    Calcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.
    Calcitonin, eel
  • HY-P1485
    Substance P(1-7) 68060-49-1 98%
    Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.
    Substance P(1-7)
  • HY-P1542
    Urotensin I 83930-33-0 98%
    Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.
    Urotensin I
  • HY-P1578
    Galanin (1-16), mouse, porcine, rat 125118-77-6 98%
    Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM.
    Galanin (1-16), mouse, porcine, rat
  • HY-P1738
    [Sar9] Substance P 77128-75-7 98.14%
    [Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.
    [Sar9] Substance P
  • HY-P1912
    Alpha 1(I) Collagen (614-639), human 210905-12-7 98.63%
    Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.
    Alpha 1(I) Collagen (614-639), human
  • HY-P1922
    γ-2-MSH (41-58), amide 799841-81-9 98.80%
    γ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands.
    γ-2-MSH (41-58), amide
  • HY-P3069
    γ-Neuropeptide (rabbit) 114882-65-4 99.99%
    γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.
    γ-Neuropeptide (rabbit)
  • HY-P3219
    N-Acetyloxytocin 10551-48-1
    N-Acetyloxytocin is isolated and characterized in the neurointermediate lobe of the rat pituitary (NIL) and their presence in several brain areas of the rat.
    N-Acetyloxytocin
  • HY-P3582
    sGnRH-A 96497-82-4 98%
    sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A stimulates growth hormone secretion. sGnRH-A also can be used as an inducer of ovulation by artificial insemination.
    sGnRH-A
  • HY-P4676
    Lys-(Des-Arg9,Leu8)-Bradykinin 71800-37-8 98.23%
    Lys-(Des-Arg9,Leu8)-Bradykinin is a bradykinin B1 receptor antagonist.
    Lys-(Des-Arg9,Leu8)-Bradykinin
  • HY-P4697
    pTH (44-68) (human) 64421-69-8 98%
    pTH (44-68) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (44-68) (human)
  • HY-P4750
    Acetyl-(D-Arg2)-GRF (1-29) amide (human) 93942-91-7 99.67%
    Acetyl-(D-Arg2)-GRF (1-29) amide (human) is an antagonist of growth hormone releasing factor (GRF). Acetyl-(D-Arg2)-GRF (1-29) amide (human) inhibits the release of growth hormone (GH) and can be used for endocrine research.
    Acetyl-(D-Arg2)-GRF (1-29) amide (human)
  • HY-P5213
    Vasopressin Dimer (parallel) (TFA) 99.55%
    Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR.
    Vasopressin Dimer (parallel) (TFA)
  • HY-P7061
    ALX 40-4C 143413-49-4
    ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.
    ALX 40-4C
Cat. No. Product Name / Synonyms Application Reactivity