2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0205S1
    Candesartan-d5 1189650-58-5
    Candesartan-d5 is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
    Candesartan-d5
  • HY-B0234S4
    Estrone-d2-1 56588-58-0
    Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells.
    Estrone-d2-1
  • HY-B0260S3
    Methylprednisolone-d7 99.73%
    Methylprednisolone-d7 is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
    Methylprednisolone-d7
  • HY-B0298AS
    Clemastine-d5 fumarate 99.48%
    Clemastine-d5 (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
    Clemastine-d5 fumarate
  • HY-B0573S1
    Propranolol-d7 (ring-d7) 344298-99-3 99.38%
    Propranolol-d7 (ring-d7) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
    Propranolol-d7 (ring-d7)
  • HY-B0636S3
    Triamcinolone acetonide-d6 352431-33-5 99.12%
    Triamcinolone acetonide-d6 is deuterium labeled Triamcinolone acetonide.
    Triamcinolone acetonide-d6
  • HY-N0019S1
    Daidzein-d6 291759-05-2
    Daidzein-d6 is a deuterium labeled Daidzein (HY-N0019). Daidzein is a soy isoflavone, which acts as a PPAR activator.
    Daidzein-d6
  • HY-N0470S4
    L-Lysine-d8 hydrochloride 344298-93-7 99.88%
    L-Lysine-d8 (hydrochloride) is the deuterium labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-d8 hydrochloride
  • HY-W009934
    2-Phenyl-2-(2-pyridyl)acetonitrile 5005-36-7 99.97%
    2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 metabolized by the supernatant fraction of rat liver homogenate. SC 15396 is an antigastrin that inhibits gastric secretion.
    2-Phenyl-2-(2-pyridyl)acetonitrile
  • HY-W015026
    Isobutylparaben 4247-02-3 98.87%
    Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics.
    Isobutylparaben
  • HY-W653723
    N-Nitrosodicyclohexylamine 947-92-2 ≥99.0%
    N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein.
    N-Nitrosodicyclohexylamine
  • HY-W1006471
    Estrogen receptor-agonist-1 263717-32-4 98.69%
    Estrogen receptor-agonist-1 (compound 4e) is a estrogen receptor (ER) agonist that binds to ERα with high affinity.
    Estrogen receptor-agonist-1
  • HY-16171
    Diphenmanil methylsulfate 62-97-5 99.74%
    Diphemanil methylsulfate is a quaternary ammonium anticholinergic.
    Diphenmanil methylsulfate
  • HY-17391
    Pamabrom 606-04-2 99.92%
    Pamabrom is a diuretic that acts on the opioid receptor-nitric oxide (NO) -cyclic guanosine monophosphate (cGMP) -K+ channel pathway. Pamabrom exerts peripheral antinociceptive activity by activating this pathway. The mechanism involves activating opioid receptors, promoting the release of nitric oxide, and then influencing cyclic guanosine monophosphate and K channels to produce an analgesic effect. Pamabrom is orally active and is mainly used in the research and treatment of premenstrual syndrome and primary dysmenorrhea[1].
    Pamabrom
  • HY-Y1324
    Sodium phosphate dibasic dodecahydrate 10039-32-4 ≥98.0%
    Phosphoric acid disodium dodecahydrate is an inorganic compound and food additive. Phosphoric acid disodium dodecahydrate promotes gel formation, improves food texture and thermal properties of materials. Phosphoric acid disodium dodecahydrate induces glomerular calcification. Phosphoric acid disodium dodecahydrate can be used in kidney disease research.
    Sodium phosphate dibasic dodecahydrate
  • HY-Z0833
    Bazedoxifene N-Oxide 1174289-22-5 98%
    Bazedoxifene N-Oxide is the oxidative degradation product of selective estrogen receptor modulator (SERM) Bazedoxifene.
    Bazedoxifene N-Oxide
  • HY-101695
    EP1-antagonist-1 851204-35-8 98.60%
    EP1-antagonist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5.
    EP1-antagonist-1
  • HY-108952
    17,17-(Ethylenedioxy)androst-4-en-3-one 1044-89-9 99.82%
    17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)androst-4-en-3-one can inhibit the reductase activity and inhibit the bond of a receptor protein and 5α-DHT.
    17,17-(Ethylenedioxy)androst-4-en-3-one
  • HY-113031
    16a-Hydroxydehydroisoandrosterone 1232-73-1 98.40%
    16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.
    16a-Hydroxydehydroisoandrosterone
  • HY-131100
    Homo Sildenafil 642928-07-2 99.32%
    Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor.
    Homo Sildenafil
Cat. No. Product Name / Synonyms Application Reactivity