2. Natural Products
  3. Plants
  4. Meliaceae
  5. Melia toosendan Sieb. et Zucc.

Melia toosendan Sieb. et Zucc.

Melia toosendan Sieb. et Zucc. (4):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0263
    Toosendanin 58812-37-6 98.74%
    Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.
    Toosendanin
  • HY-N7694
    Isotoosendanin 97871-44-8 99.51%
    Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation.
    Isotoosendanin
  • HY-N1142
    Torachrysone 22649-04-3
    Torachrysone (Nakahalene; Trachrysone), a naphthalene, can be isolated from Cassia tora L.
    Torachrysone
  • HY-N0263R
    Toosendanin (Standard) 58812-37-6
    Toosendanin (Standard) is the analytical standard of Toosendanin. This product is intended for research and analytical applications. Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.
    Toosendanin (Standard)