2. Autophagy Membrane Transporter/Ion Channel
  3. Autophagy Calmodulin
  4. Metofenazate

Metofenazate  (Synonyms: Methophenazine)

Cat. No.: HY-100263 Purity: 98.73%
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Metofenazate is a selective calmodulin inhibitor.

For research use only. We do not sell to patients.

Metofenazate

Metofenazate Chemical Structure

CAS No. : 388-51-2

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Oil
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Metofenazate:

Metofenazate Related Antibodies

Top Publications Citing Use of Products

View All Calmodulin Isoform Specific Products:

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CALM1 CALM2 CALM3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Metofenazate is a selective calmodulin inhibitor.

IC50 & Target

Calmodulin[1]
Molecular Weight

598.15

Formula

C31H36ClN3O5S
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1)C5=CC(OC)=C(OC)C(OC)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (167.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6718 mL 8.3591 mL 16.7182 mL
5 mM 0.3344 mL 1.6718 mL 3.3436 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.18 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6718 mL 8.3591 mL 16.7182 mL 41.7955 mL
5 mM 0.3344 mL 1.6718 mL 3.3436 mL 8.3591 mL
10 mM 0.1672 mL 0.8359 mL 1.6718 mL 4.1796 mL
15 mM 0.1115 mL 0.5573 mL 1.1145 mL 2.7864 mL
20 mM 0.0836 mL 0.4180 mL 0.8359 mL 2.0898 mL
25 mM 0.0669 mL 0.3344 mL 0.6687 mL 1.6718 mL
30 mM 0.0557 mL 0.2786 mL 0.5573 mL 1.3932 mL
40 mM 0.0418 mL 0.2090 mL 0.4180 mL 1.0449 mL
50 mM 0.0334 mL 0.1672 mL 0.3344 mL 0.8359 mL
60 mM 0.0279 mL 0.1393 mL 0.2786 mL 0.6966 mL
80 mM 0.0209 mL 0.1045 mL 0.2090 mL 0.5224 mL
100 mM 0.0167 mL 0.0836 mL 0.1672 mL 0.4180 mL
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Metofenazate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metofenazate388-51-2MethophenazineAutophagyCalmodulinCaMCalcium-Modulated ProteinInhibitorinhibitorinhibit

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