2. Anti-infection
  3. Bacterial Antibiotic
  4. Delamanid

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids.

For research use only. We do not sell to patients.

Delamanid

Delamanid Chemical Structure

CAS No. : 681492-22-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Delamanid:

Delamanid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 CC50
107.5 μg/mL
Compound: Delamanid
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
[PMID: 26487912]
MRC5 IC50
> 64 μM
Compound: 5; OPC-67683
Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay
Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay
[PMID: 26901446]
MRC5 IC50
0.43 μM
Compound: 5; OPC-67683
Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC5 cells assessed as parasite growth inhibition incubated for 7 days by chlorophenol red alpha-D-galactopyranoside-based assay
Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC5 cells assessed as parasite growth inhibition incubated for 7 days by chlorophenol red alpha-D-galactopyranoside-based assay
[PMID: 26901446]
In Vitro

Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex[1].
Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis[2].
Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Delamanid Related Antibodies
In Vivo

Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

534.48

Formula

C25H25F3N4O6
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

FC(F)(F)OC1=CC=C(OC2CCN(C3=CC=C(OC[C@@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)C=C3)CC2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (37.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 2 mg/mL (3.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8710 mL 9.3549 mL 18.7098 mL
5 mM 0.3742 mL 1.8710 mL 3.7420 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

SDS (419 KB)

COA (245 KB) HNMR (292 KB) RP-HPLC (243 KB) LCMS (93 KB) OR (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.8710 mL 9.3549 mL 18.7098 mL 46.7744 mL
DMSO 5 mM 0.3742 mL 1.8710 mL 3.7420 mL 9.3549 mL
10 mM 0.1871 mL 0.9355 mL 1.8710 mL 4.6774 mL
15 mM 0.1247 mL 0.6237 mL 1.2473 mL 3.1183 mL
20 mM 0.0935 mL 0.4677 mL 0.9355 mL 2.3387 mL
25 mM 0.0748 mL 0.3742 mL 0.7484 mL 1.8710 mL
30 mM 0.0624 mL 0.3118 mL 0.6237 mL 1.5591 mL
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Delamanid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delamanid681492-22-8OPC-67683OPC67683OPC 67683BacterialAntibioticInhibitorinhibitorinhibit

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